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meg-4 J domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180497, updated on 4-Jan-2025

Summary

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Official Symbol
meg-4
Official Full Name
J domain-containing protein
Primary source
WormBase:WBGene00016485
Locus tag
CELE_C36C9.1
See related
AllianceGenome:WB:WBGene00016485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in P granule assembly; germ cell proliferation; and organelle localization. Located in P granule. Is expressed in pharynx. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See meg-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (1682954..1686419)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Transposase Neighboring gene Transposase Neighboring gene EF-hand domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote. Wu Y, et al. Mol Biol Cell, 2019 Feb 1. PMID 30540524, Free PMC Article
  2. Regulation of biomolecular condensates by interfacial protein clusters. Folkmann AW, et al. Science, 2021 Sep 10. PMID 34516789, Free PMC Article
  3. Large RNP granules in Caenorhabditis elegans oocytes have distinct phases of RNA-binding proteins. Elaswad MT, et al. G3 (Bethesda), 2022 Aug 25. PMID 35816006, Free PMC Article
  4. GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance. Chen W, et al. Nat Commun, 2022 Sep 9. PMID 36085149, Free PMC Article
  5. Germ Granules Govern Small RNA Inheritance. Lev I, et al. Curr Biol, 2019 Sep 9. PMID 31378614, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germ cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organelle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
J domain-containing protein
NP_508310.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1682954..1686419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075909.4 → NP_508310.1  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508310.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZK8
Nucleotide Protein
Heading Accession and Version

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