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Neurodevelopmental disorder

MedGen UID:
453059
Concept ID:
C1535926
Mental or Behavioral Dysfunction
Synonyms: Child Mental Disorder; Child Mental Disorders; Disorder, Child Mental; Disorder, Neurodevelopmental; Mental Disorder, Child; Mental Disorders Diagnosed in Childhood; Mental Disorders Usually Diagnosed in Infancy, Childhood or Adolescence; Mental Disorders, Child; Neurodevelopmental Disorder; Neurodevelopmental Disorders; Neurodevelopmental Disorders Usually Diagnosed in Infancy, Childhood or Adolescence
SNOMED CT: Neurodevelopmental disorder (700364009)
 
Monarch Initiative: MONDO:0700092

Definition

Neurodevelopmental disorder is a behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurodevelopmental disorder

Professional guidelines

PubMed

Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS
Lancet Neurol 2023 Feb;22(2):147-158. Epub 2022 Oct 28 doi: 10.1016/S1474-4422(22)00303-9. PMID: 36354027Free PMC Article
Mechler K, Banaschewski T, Hohmann S, Häge A
Pharmacol Ther 2022 Feb;230:107940. Epub 2021 Jun 23 doi: 10.1016/j.pharmthera.2021.107940. PMID: 34174276
Hyman SL, Levy SE, Myers SM; COUNCIL ON CHILDREN WITH DISABILITIES, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
Pediatrics 2020 Jan;145(1) Epub 2019 Dec 16 doi: 10.1542/peds.2019-3447. PMID: 31843864

Recent clinical studies

Etiology

Hughes HK, R J Moreno, Ashwood P
Brain Behav Immun 2023 Feb;108:245-254. Epub 2022 Dec 6 doi: 10.1016/j.bbi.2022.12.001. PMID: 36494048
Turner TN, Wilfert AB, Bakken TE, Bernier RA, Pepper MR, Zhang Z, Torene RI, Retterer K, Eichler EE
Am J Hum Genet 2019 Dec 5;105(6):1274-1285. Epub 2019 Nov 27 doi: 10.1016/j.ajhg.2019.11.003. PMID: 31785789Free PMC Article
Mirkovic B, Gérardin P
Encephale 2019 Apr;45(2):169-174. Epub 2019 Feb 5 doi: 10.1016/j.encep.2018.11.005. PMID: 30736970
Cimino PJ, Gutmann DH
Handb Clin Neurol 2018;148:799-811. doi: 10.1016/B978-0-444-64076-5.00051-X. PMID: 29478615
Nicolini C, Fahnestock M
Exp Neurol 2018 Jan;299(Pt A):217-227. Epub 2017 May 2 doi: 10.1016/j.expneurol.2017.04.017. PMID: 28472621

Diagnosis

Morris-Rosendahl DJ, Crocq MA
Dialogues Clin Neurosci 2020 Mar;22(1):65-72. doi: 10.31887/DCNS.2020.22.1/macrocq. PMID: 32699506Free PMC Article
Antshel KM, Russo N
Curr Psychiatry Rep 2019 Mar 22;21(5):34. doi: 10.1007/s11920-019-1020-5. PMID: 30903299
Cimino PJ, Gutmann DH
Handb Clin Neurol 2018;148:799-811. doi: 10.1016/B978-0-444-64076-5.00051-X. PMID: 29478615
Gulati S, Sondhi V
Indian J Pediatr 2018 Nov;85(11):1006-1016. Epub 2017 Nov 20 doi: 10.1007/s12098-017-2475-1. PMID: 29152685
Stamberger H, Nikanorova M, Willemsen MH, Accorsi P, Angriman M, Baier H, Benkel-Herrenbrueck I, Benoit V, Budetta M, Caliebe A, Cantalupo G, Capovilla G, Casara G, Courage C, Deprez M, Destrée A, Dilena R, Erasmus CE, Fannemel M, Fjær R, Giordano L, Helbig KL, Heyne HO, Klepper J, Kluger GJ, Lederer D, Lodi M, Maier O, Merkenschlager A, Michelberger N, Minetti C, Muhle H, Phalin J, Ramsey K, Romeo A, Schallner J, Schanze I, Shinawi M, Sleegers K, Sterbova K, Syrbe S, Traverso M, Tzschach A, Uldall P, Van Coster R, Verhelst H, Viri M, Winter S, Wolff M, Zenker M, Zoccante L, De Jonghe P, Helbig I, Striano P, Lemke JR, Møller RS, Weckhuysen S
Neurology 2016 Mar 8;86(10):954-62. Epub 2016 Feb 10 doi: 10.1212/WNL.0000000000002457. PMID: 26865513

Therapy

Mechler K, Banaschewski T, Hohmann S, Häge A
Pharmacol Ther 2022 Feb;230:107940. Epub 2021 Jun 23 doi: 10.1016/j.pharmthera.2021.107940. PMID: 34174276
Silva EAD Junior, Medeiros WMB, Torro N, Sousa JMM, Almeida IBCM, Costa FBD, Pontes KM, Nunes ELG, Rosa MDD, Albuquerque KLGD
Trends Psychiatry Psychother 2022 Jun 13;44:e20200149. doi: 10.47626/2237-6089-2020-0149. PMID: 34043900Free PMC Article
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Karhu E, Zukerman R, Eshraghi RS, Mittal J, Deth RC, Castejon AM, Trivedi M, Mittal R, Eshraghi AA
Nutr Rev 2020 Jul 1;78(7):515-531. doi: 10.1093/nutrit/nuz092. PMID: 31876938
Thapar A, Cooper M
Lancet 2016 Mar 19;387(10024):1240-50. Epub 2015 Sep 17 doi: 10.1016/S0140-6736(15)00238-X. PMID: 26386541

Prognosis

Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Cell 2024 Apr 11;187(8):1853-1873.e15. Epub 2024 Apr 3 doi: 10.1016/j.cell.2024.02.035. PMID: 38574728
Gulati S, Sondhi V
Indian J Pediatr 2018 Nov;85(11):1006-1016. Epub 2017 Nov 20 doi: 10.1007/s12098-017-2475-1. PMID: 29152685
Nicolini C, Fahnestock M
Exp Neurol 2018 Jan;299(Pt A):217-227. Epub 2017 May 2 doi: 10.1016/j.expneurol.2017.04.017. PMID: 28472621
Thapar A, Cooper M
Lancet 2016 Mar 19;387(10024):1240-50. Epub 2015 Sep 17 doi: 10.1016/S0140-6736(15)00238-X. PMID: 26386541
Amaral DG, Schumann CM, Nordahl CW
Trends Neurosci 2008 Mar;31(3):137-45. Epub 2008 Feb 6 doi: 10.1016/j.tins.2007.12.005. PMID: 18258309

Clinical prediction guides

Sanchez-Jimeno C, Blanco-Kelly F, López-Grondona F, Losada-Del Pozo R, Moreno B, Rodrigo-Moreno M, Martinez-Cayuelas E, Riveiro-Alvarez R, Fenollar-Cortés M, Ayuso C, Rodríguez de Alba M, Lorda-Sanchez I, Almoguera B
Genes (Basel) 2021 Aug 30;12(9) doi: 10.3390/genes12091360. PMID: 34573342Free PMC Article
Biotteau M, Albaret JM, Chaix Y
Handb Clin Neurol 2020;174:3-20. doi: 10.1016/B978-0-444-64148-9.00001-6. PMID: 32977886
Fliedner A, Kirchner P, Wiesener A, van de Beek I, Waisfisz Q, van Haelst M, Scott DA, Lalani SR, Rosenfeld JA, Azamian MS, Xia F, Dutra-Clarke M, Martinez-Agosto JA, Lee H; UCLA Clinical Genomics Center, Noh GJ, Lippa N, Alkelai A, Aggarwal V, Agre KE, Gavrilova R, Mirzaa GM, Straussberg R, Cohen R, Horist B, Krishnamurthy V, McWalter K, Juusola J, Davis-Keppen L, Ohden L, van Slegtenhorst M, de Man SA, Ekici AB, Gregor A, van de Laar I, Zweier C
Am J Hum Genet 2020 Sep 3;107(3):544-554. Epub 2020 Jul 29 doi: 10.1016/j.ajhg.2020.06.019. PMID: 32730804Free PMC Article
Morris-Rosendahl DJ, Crocq MA
Dialogues Clin Neurosci 2020 Mar;22(1):65-72. doi: 10.31887/DCNS.2020.22.1/macrocq. PMID: 32699506Free PMC Article
Takumi T, Tamada K, Hatanaka F, Nakai N, Bolton PF
Neurosci Biobehav Rev 2020 Mar;110:60-76. Epub 2019 May 3 doi: 10.1016/j.neubiorev.2019.04.012. PMID: 31059731

Recent systematic reviews

Petriti U, Dudman DC, Scosyrev E, Lopez-Leon S
Syst Rev 2023 Jan 16;12(1):5. doi: 10.1186/s13643-023-02169-6. PMID: 36642718Free PMC Article
Faheem M, Akram W, Akram H, Khan MA, Siddiqui FA, Majeed I
Asian J Psychiatr 2022 Sep;75:103205. Epub 2022 Jul 14 doi: 10.1016/j.ajp.2022.103205. PMID: 35878424
Silva EAD Junior, Medeiros WMB, Torro N, Sousa JMM, Almeida IBCM, Costa FBD, Pontes KM, Nunes ELG, Rosa MDD, Albuquerque KLGD
Trends Psychiatry Psychother 2022 Jun 13;44:e20200149. doi: 10.47626/2237-6089-2020-0149. PMID: 34043900Free PMC Article
Ryan JM, Cassidy EE, Noorduyn SG, O'Connell NE
Cochrane Database Syst Rev 2017 Jun 11;6(6):CD011660. doi: 10.1002/14651858.CD011660.pub2. PMID: 28602046Free PMC Article
Cooper RE, Tye C, Kuntsi J, Vassos E, Asherson P
J Psychopharmacol 2015 Jul;29(7):753-63. Epub 2015 Jun 3 doi: 10.1177/0269881115587958. PMID: 26040902

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