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Hemorrhagic disease

MedGen UID:: 6799
•Concept ID:: C0019087
•: Disease or Syndrome

Synonyms:	Diatheses, Hemorrhagic; Diathesis, Hemorrhagic; Disorder, Hemorrhagic; Disorders, Hemorrhagic; Hemorrhagic Diatheses; Hemorrhagic Diathesis; Hemorrhagic Disorder; Hemorrhagic Disorders

Monarch Initiative:	MONDO:0002243

Definition

Evidence of a hemorrhagic condition. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHemorrhagic disease

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Hematopoietic and Lymphatic System Disorder
        Hematologic disorder
        Hemorrhagic disease
        Afibrinogenemia
        Autoimmune thrombocytopenic purpura
        Bernard Soulier syndrome
        Bernard-Soulier syndrome type C
        Bernard-Soulier syndrome, type A1
        Bernard-Soulier syndrome, type A1 (recessive)
        Bernard-Soulier syndrome, type B
        Congenital factor V deficiency
        Disseminated intravascular coagulation
        Acute disseminated intravascular coagulation
        Chronic disseminated intravascular coagulation
        Disseminated intravascular coagulation in newborn
        Essential thrombocythemia
        Thrombocythemia 1
        Thrombocythemia 2
        Thrombocythemia 3
        Factor VII deficiency
        Acquired factor VII deficiency
        Factor VII Inactivation
        Congenital factor VII deficiency
        Factor X deficiency
        Acquired factor X deficiency
        Factor X Inactivation
        Hereditary factor X deficiency disease
        Factor XII deficiency disease
        Acquired Factor XII Deficiency
        Factor XII Inactivation
        Hereditary factor XII deficiency disease
        Glanzmann thrombasthenia
        Hereditary factor IX deficiency disease
        HEMOPHILIA B BRANDENBURG
        Hemophilia B leyden
        Hemophilia b(m)
        Mild hemophilia B
        Moderately severe hemophilia B
        Severe hemophilia B
        Symptomatic form of hemophilia B in female carriers
        Hereditary factor VIII deficiency disease
        Hemophilia A with vascular abnormality
        Mild hemophilia A
        Moderately severe hemophilia A
        Severe hemophilia A
        Symptomatic form of hemophilia A in female carriers
        Hereditary factor XI deficiency disease
        Hereditary factor XIII deficiency disease
        Prothrombin deficiency
        Acquired hypoprothrombinemia
        Factor II Inactivation
        Congenital prothrombin deficiency
        Storage pool disease of platelets
        Hermansky-Pudlak syndrome
        Hermansky-Pudlak syndrome 1
        Hermansky-Pudlak syndrome 2
        Hermansky-Pudlak syndrome 3
        Hermansky-Pudlak syndrome 4
        Hermansky-Pudlak syndrome 5
        Hermansky-Pudlak syndrome 6
        Hermansky-Pudlak syndrome 7
        Hermansky-Pudlak syndrome 8
        Hermansky-Pudlak syndrome 9
        Hermansky-Pudlak syndrome 10
        Hermansky-Pudlak syndrome with pulmonary fibrosis
        Hermansky-Pudlak syndrome without pulmonary fibrosis
        Vascular hemostatic disease
        Cavernous hemangioma
        Cardiac Cavernous Hemangioma
        Cavernous hemangioma of colon
        Cavernous hemangioma of orbit
        Cavernous hemangioma of retina
        Cavernous hemangioma of the face
        Central Nervous System Cavernous Hemangioma
        Giant hemangioma
        Liver cavernous hemangioma
        Skin Cavernous Hemangioma
        Thyroid Gland Cavernous Hemangioma
        Cryoglobulinemia
        Ehlers-Danlos syndrome
        Arthrochalasia Ehlers-Danlos syndrome
        Bethlem myopathy 2
        Brittle cornea syndrome
        Ehlers-Danlos syndrome due to tenascin-X deficiency
        Ehlers-Danlos syndrome progeroid type
        Ehlers-Danlos syndrome, arthrochalasia type
        Ehlers-Danlos syndrome, cardiac valvular type
        Ehlers-Danlos syndrome, classic type
        Ehlers-Danlos syndrome, classic type, 1
        Ehlers-Danlos syndrome, classic type, 2
        Ehlers-Danlos syndrome, classic-like, 2
        Ehlers-Danlos syndrome, dermatosparaxis type
        Ehlers-Danlos syndrome, kyphoscoliotic type 1
        Ehlers-Danlos syndrome, musculocontractural type
        Ehlers-Danlos syndrome, periodontitis type
        Ehlers-Danlos syndrome, type 3
        Ehlers-Danlos syndrome, type 4
        Kyphoscoliotic Ehlers-Danlos syndrome
        Spondylodysplastic Ehlers-Danlos syndrome
        X-linked Ehlers-Danlos syndrome
        Hereditary hemorrhagic telangiectasia
        Hereditary hemorrhagic telangiectasia type 3
        Hereditary hemorrhagic telangiectasia type 4
        Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome
        Telangiectasia, hereditary hemorrhagic, type 1
        Telangiectasia, hereditary hemorrhagic, type 2
        Telangiectasia, hereditary hemorrhagic, type 5
        Hyperglobulinemic purpura
        Immunoglobulin A vasculitis
        Multiple myeloma
        Multiple Myeloma by ISS Stage
        Multiple Myeloma by RISS Stage
        Multiple Myeloma Post-Transplant Lymphoproliferative Disorder
        Non-secretory plasma cell myeloma
        Osteosclerotic plasma cell myeloma
        Plasma cell leukemia
        Recurrent Multiple Myeloma
        Refractory Multiple Myeloma
        Smoldering plasma cell myeloma
        Pseudoxanthoma elasticum
        Acquired pseudoxanthoma elasticum
        Autosomal recessive inherited pseudoxanthoma elasticum
        Inherited pseudoxanthoma elasticum
        Scurvy
        Shwartzman phenomenon
        Waldenstrom macroglobulinemia
        Familial Waldenstrom Macroglobulinemia
        Macroglobulinemia, Waldenstrom, 1
        Macroglobulinemia, Waldenstrom, 2
        Macroglobulinemia, Waldenstrom, somatic
        Recurrent Waldenstrom Macroglobulinemia
        Refractory Waldenstrom Macroglobulinemia
        Smoldering Waldenstrom Macroglobulinemia
        Vitamin K deficiency
        Vitamin K Deficiency Bleeding
        von Willebrand disorder
        Acquired von willebrand syndrome
        Hereditary von Willebrand disease
        Pseudo von Willebrand disease
        von Willebrand disease type 1
        von Willebrand disease type 2
        von Willebrand disease type 3
        Von Willebrand disease, X-linked form
        Von Willebrand disease type 2A
        Von Willebrand disease type 2B
        von Willebrand disease type 2M
        von Willebrand disease type 2N
        Waterhouse-Friderichsen Syndrome
        Wiskott-Aldrich syndrome

Professional guidelines

PubMed

Conservative management of the acute abdomen secondary to hemorrhagic disease of the ovary.

Tohya T
Int J Gynaecol Obstet 2003 Feb;80(2):165-6. doi: 10.1016/s0020-7292(02)00386-7. PMID: 12566190

Prognostic criteria in anoxic-hemorrhagic disease.

Ruggiero R, Bandieramonte G, De Marinis P, Colangelo M, Carannante G, Buonocore MC, Ambrosio A
J Neuroradiol 1987;14(3):223-31. PMID: 3440879

Differential diagnosis and treatment in hemorrhagic disease.

LEWIS JH, DIDISHEIM P
AMA Arch Intern Med 1957 Jul;100(1):157-68. doi: 10.1001/archinte.1957.00260070171022. PMID: 13434522

See all (21)

Recent clinical studies

Etiology

Structural insights on the nucleoprotein C-terminal domain of Měnglà virus.

Ferrero DS, Tomás Gilabert O, Verdaguer N
Microbiol Spectr 2023 Dec 12;11(6):e0237323. Epub 2023 Oct 27 doi: 10.1128/spectrum.02373-23. PMID: 37888996 Free PMC Article

Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021-2022.

Bonney JHK, Sanders T, Pratt D, Agbodzi B, Laryea D, Agyeman NKF, Kumordjie S, Attiku K, Adams PL, Boateng GA, Ohene SA, Tamal C, Mawuli G, Yeboah C, Dadzie S, Kubio C, Asiedu-Bekoe F, Odoom JK
Emerg Infect Dis 2023 Sep;29(9):1818-1826. doi: 10.3201/eid2909.221671. PMID: 37610174 Free PMC Article

Educating Parents on Vitamin K Prophylaxis for Newborns.

Holley SL, Green K, Mills M, Detterman C, Rappold MF, Thayer S
Nurs Womens Health 2020 Aug;24(4):283-293. doi: 10.1016/j.nwh.2020.05.005. PMID: 32778394

Investigator clinical trials: How can we ask the question?

Schved JF
Haemophilia 2020 Apr;26 Suppl 3:20-21. doi: 10.1111/hae.13887. PMID: 32356344

Vitamin K deficiency and hemorrhage in infancy.

Greer FR
Clin Perinatol 1995 Sep;22(3):759-77. PMID: 8521692

See all (165)

Diagnosis

Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021-2022.

Glanzmann thrombasthenia.

Nurden AT
Orphanet J Rare Dis 2006 Apr 6;1:10. doi: 10.1186/1750-1172-1-10. PMID: 16722529 Free PMC Article

Enterovirus uveitis.

Lashkevich VA, Koroleva GA, Lukashev AN, Denisova EV, Katargina LA
Rev Med Virol 2004 Jul-Aug;14(4):241-54. doi: 10.1002/rmv.433. PMID: 15248252

Vitamin K deficiency.

Hathaway WE
Southeast Asian J Trop Med Public Health 1993;24 Suppl 1:5-9. PMID: 7886607

Differential diagnosis and treatment in hemorrhagic disease.

LEWIS JH, DIDISHEIM P
AMA Arch Intern Med 1957 Jul;100(1):157-68. doi: 10.1001/archinte.1957.00260070171022. PMID: 13434522

See all (149)

Therapy

Ebola Virus: Pathogenesis and Countermeasure Development.

Furuyama W, Marzi A
Annu Rev Virol 2019 Sep 29;6(1):435-458. doi: 10.1146/annurev-virology-092818-015708. PMID: 31567063

Ebola haemorrhagic fever virus: pathogenesis, immune responses, potential prevention.

Marcinkiewicz J, Bryniarski K, Nazimek K
Folia Med Cracov 2014;54(3):39-48. PMID: 25694094

Glanzmann thrombasthenia.

Nurden AT
Orphanet J Rare Dis 2006 Apr 6;1:10. doi: 10.1186/1750-1172-1-10. PMID: 16722529 Free PMC Article

Vitamin K deficiency and hemorrhage in infancy.

Greer FR
Clin Perinatol 1995 Sep;22(3):759-77. PMID: 8521692

Concepts of clot lysis.

Francis CW, Marder VJ
Annu Rev Med 1986;37:187-204. doi: 10.1146/annurev.me.37.020186.001155. PMID: 2939790

See all (141)

Prognosis

Structural and molecular biology of Sabiá virus.

Bezerra EH, Melo-Hanchuk TD, Marques RE
Exp Biol Med (Maywood) 2023 Oct;248(19):1624-1634. Epub 2023 Nov 8 doi: 10.1177/15353702231199071. PMID: 37937408 Free PMC Article

Bioclinical Test to Predict Nephropathia Epidemica Severity at Hospital Admission.

Hentzien M, Mestrallet S, Halin P, Pannet LA, Lebrun D, Dramé M, Bani-Sadr F, Galempoix JM, Strady C, Reynes JM, Penalba C, Servettaz A
Emerg Infect Dis 2018 Jun;24(6):1045-1054. doi: 10.3201/eid2406.172160. PMID: 29774835 Free PMC Article

Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China.

Rai RK, Luo J, Tulchinsky TH
World J Pediatr 2017 Feb;13(1):15-19. Epub 2016 Nov 15 doi: 10.1007/s12519-016-0062-6. PMID: 27878777

Glanzmann thrombasthenia.

Nurden AT
Orphanet J Rare Dis 2006 Apr 6;1:10. doi: 10.1186/1750-1172-1-10. PMID: 16722529 Free PMC Article

Twenty-seven years of experience with oral vitamin K1 therapy in neonates.

Clark FI, James EJ
J Pediatr 1995 Aug;127(2):301-4. doi: 10.1016/s0022-3476(95)70315-2. PMID: 7636660

See all (70)

Clinical prediction guides

Spatio-temporal spread and evolution of Lassa virus in West Africa.

Wang X, Ye X, Li R, Zai X, Hu M, Wang S, Ren H, Jin Y, Xu J, Yue J
BMC Infect Dis 2024 Mar 14;24(1):314. doi: 10.1186/s12879-024-09200-8. PMID: 38486143 Free PMC Article

Structural and molecular biology of Sabiá virus.

Bezerra EH, Melo-Hanchuk TD, Marques RE
Exp Biol Med (Maywood) 2023 Oct;248(19):1624-1634. Epub 2023 Nov 8 doi: 10.1177/15353702231199071. PMID: 37937408 Free PMC Article

Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice.

Xie Z, Jiang J, Cao L, Jiang M, Yang F, Ma Z, Wang Z, Ruan C, Liu H, Zhou L
Clin Genet 2021 Aug;100(2):213-218. Epub 2021 May 5 doi: 10.1111/cge.13975. PMID: 33928629

Enterovirus uveitis.

Lashkevich VA, Koroleva GA, Lukashev AN, Denisova EV, Katargina LA
Rev Med Virol 2004 Jul-Aug;14(4):241-54. doi: 10.1002/rmv.433. PMID: 15248252

Hemothorax in the newborn.

Oppermann HC, Wille L
Pediatr Radiol 1980 Apr;9(3):129-34. doi: 10.1007/BF01464305. PMID: 7393666

See all (103)