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Smoldering Waldenstrom Macroglobulinemia

MedGen UID:
1650906
•Concept ID:
C4744445
•
Neoplastic Process
Synonyms: Asymptomatic Waldenstrom Macroglobulinemia; Smoldering (Asymptomatic) Waldenstrom Macroglobulinemia

Definition

Waldenstrom macroglobulinemia with serum IgM monoclonal protein equal or more than 3 g/dL and/or at least 10% bone marrow lymphoplasmacytic infiltration but no evidence of constitutional symptoms, symptomatic anemia, or hyperviscosity. (Blood 2008, 112:2709) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmoldering Waldenstrom Macroglobulinemia

Professional guidelines

PubMed

Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Waldenström's macroglobulinemia: treatment approaches for newly diagnosed and relapsed disease.
Hodge LS, Ansell SM
Transfus Apher Sci 2013 Aug;49(1):19-23. Epub 2013 Jun 15 doi: 10.1016/j.transci.2013.05.019. PMID: 23773867
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article

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