U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atypical lipomatous tumor

MedGen UID:
266102
•Concept ID:
C1266129
•
Neoplastic Process
Synonyms: Atypical Lipoma; Atypical Lipomas; Lipoma, Atypical; Lipomas, Atypical
SNOMED CT: Atypical lipoma (116063003); Atypical lipomatous tumor (116063003)
 
Monarch Initiative: MONDO:0006097

Definition

A locally aggressive mesenchymal neoplasm composed either entirely or partly of an adipocytic proliferation showing at least focal nuclear atypia in both adipocytes and stromal cells. ""Atypical lipomatous tumor"" and ""well-differentiated liposarcoma"" are synonyms describing lesions that are morphologically and genetically identical. Amplification of MDM2 and/or CDK4 is almost always present. (WHO 2020) [from NCI]

Professional guidelines

PubMed

Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Recent Advancement in Atypical Lipomatous Tumor Research.
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature.
Kang JY, Kim HJ, Wojno TH, Yeung AM, Mendoza PR, Grossniklaus HE
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S134-S140. doi: 10.1097/IOP.0000000000001804. PMID: 32991496
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Diagnosis

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Atypical lipomatous tumor/well-differentiated liposarcoma: what is it?
Hogg ME, Wayne JD
Surg Oncol Clin N Am 2012 Apr;21(2):333-40. Epub 2012 Jan 28 doi: 10.1016/j.soc.2011.12.007. PMID: 22365523
Atypical lipomatous tumor of the breast.
Valero MG, Raut CP, Lotfi P, Golshan M
J Clin Oncol 2011 Nov 1;29(31):e766-8. Epub 2011 Sep 19 doi: 10.1200/JCO.2011.36.9058. PMID: 21931026
Atypical lipomatous tumor: molecular characterization.
Arrigoni G, Doglioni C
Curr Opin Oncol 2004 Jul;16(4):355-8. doi: 10.1097/01.cco.0000127878.85125.53. PMID: 15187890

Therapy

MRI radiomics-based machine learning for classification of deep-seated lipoma and atypical lipomatous tumor of the extremities.
Gitto S, Interlenghi M, Cuocolo R, Salvatore C, Giannetta V, Badalyan J, Gallazzi E, Spinelli MS, Gallazzi M, Serpi F, Messina C, Albano D, Annovazzi A, Anelli V, Baldi J, Aliprandi A, Armiraglio E, Parafioriti A, Daolio PA, Luzzati A, Biagini R, Castiglioni I, Sconfienza LM
Radiol Med 2023 Aug;128(8):989-998. Epub 2023 Jun 19 doi: 10.1007/s11547-023-01657-y. PMID: 37335422Free PMC Article
Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Recent Advancement in Atypical Lipomatous Tumor Research.
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Managing Liposarcomas: Cutting Through the Fat.
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163
Application of molecular biology to individualize therapy for patients with liposarcoma.
Abbas Manji G, Singer S, Koff A, Schwartz GK
Am Soc Clin Oncol Educ Book 2015:213-8. doi: 10.14694/EdBook_AM.2015.35.213. PMID: 25993159

Prognosis

Biology and Management of Deep-seated Atypical Lipomatous Tumor of the Extremities.
Nishio J, Nakayama S, Chijiiwa Y, Aoki M
Anticancer Res 2023 Oct;43(10):4295-4301. doi: 10.21873/anticanres.16624. PMID: 37772567
Liposarcoma of the pleural cavity.
Kawai T, Nakashima H, Washimi K, Yokose T, Matsuo T, Nakayama M, Shinohara N, Kuroda H, Ishida K, Akiba J, Ishikawa M, Urabe S, Shiraishi J, Shiraishi T, Sakamoto A, Matsukuma S
Hum Pathol 2023 Jun;136:105-113. Epub 2023 Apr 5 doi: 10.1016/j.humpath.2023.03.009. PMID: 37023867
The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201
Atypical lipomatous tumor/well-differentiated liposarcoma: what is it?
Hogg ME, Wayne JD
Surg Oncol Clin N Am 2012 Apr;21(2):333-40. Epub 2012 Jan 28 doi: 10.1016/j.soc.2011.12.007. PMID: 22365523
Atypical lipomatous tumor of the breast.
Valero MG, Raut CP, Lotfi P, Golshan M
J Clin Oncol 2011 Nov 1;29(31):e766-8. Epub 2011 Sep 19 doi: 10.1200/JCO.2011.36.9058. PMID: 21931026

Clinical prediction guides

Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?
Kilpatrick SE
Hum Pathol 2024 May;147:82-91. Epub 2023 Dec 21 doi: 10.1016/j.humpath.2023.12.005. PMID: 38135062
Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.
Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920
Atypical Spindle Cell Lipomatous Tumor: Clinicopathologic Characterization of 232 Cases Demonstrating a Morphologic Spectrum.
Mariño-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD
Am J Surg Pathol 2017 Feb;41(2):234-244. doi: 10.1097/PAS.0000000000000770. PMID: 27879515
The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Recent systematic reviews

Radiomics-based approaches outperform visual analysis for differentiating lipoma from atypical lipomatous tumors: a review.
Haidey J, Low G, Wilson MP
Skeletal Radiol 2023 Jun;52(6):1089-1100. Epub 2022 Nov 16 doi: 10.1007/s00256-022-04232-0. PMID: 36385583
Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.
Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...