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Atypical lipomatous tumor

MedGen UID:
266102
•Concept ID:
C1266129
•
Neoplastic Process
Synonyms: Atypical Lipoma; Atypical Lipomas; Lipoma, Atypical; Lipomas, Atypical
SNOMED CT: Atypical lipoma (116063003); Atypical lipomatous tumor (116063003)
 
Monarch Initiative: MONDO:0006097

Definition

A locally aggressive mesenchymal neoplasm composed either entirely or partly of an adipocytic proliferation showing at least focal nuclear atypia in both adipocytes and stromal cells. ""Atypical lipomatous tumor"" and ""well-differentiated liposarcoma"" are synonyms describing lesions that are morphologically and genetically identical. Amplification of MDM2 and/or CDK4 is almost always present. (WHO 2020) [from NCI]

Professional guidelines

PubMed

Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Dedifferentiated Liposarcoma: A Comprehensive Historical Review With Proposed Evidence-based Guidelines Regarding a Diagnosis in Need of Further Clarification.
Kilpatrick SE
Adv Anat Pathol 2021 Nov 1;28(6):426-438. doi: 10.1097/PAP.0000000000000314. PMID: 34326285
The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Recent Advancement in Atypical Lipomatous Tumor Research.
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature.
Kang JY, Kim HJ, Wojno TH, Yeung AM, Mendoza PR, Grossniklaus HE
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S134-S140. doi: 10.1097/IOP.0000000000001804. PMID: 32991496
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315

Diagnosis

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Recent Advancement in Atypical Lipomatous Tumor Research.
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma.
Briski LM, Jorns JM
Arch Pathol Lab Med 2018 Feb;142(2):268-274. doi: 10.5858/arpa.2016-0380-RSR2. PMID: 29372852

Therapy

MRI radiomics-based machine learning for classification of deep-seated lipoma and atypical lipomatous tumor of the extremities.
Gitto S, Interlenghi M, Cuocolo R, Salvatore C, Giannetta V, Badalyan J, Gallazzi E, Spinelli MS, Gallazzi M, Serpi F, Messina C, Albano D, Annovazzi A, Anelli V, Baldi J, Aliprandi A, Armiraglio E, Parafioriti A, Daolio PA, Luzzati A, Biagini R, Castiglioni I, Sconfienza LM
Radiol Med 2023 Aug;128(8):989-998. Epub 2023 Jun 19 doi: 10.1007/s11547-023-01657-y. PMID: 37335422Free PMC Article
Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Recent Advancement in Atypical Lipomatous Tumor Research.
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Managing Liposarcomas: Cutting Through the Fat.
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163
Application of molecular biology to individualize therapy for patients with liposarcoma.
Abbas Manji G, Singer S, Koff A, Schwartz GK
Am Soc Clin Oncol Educ Book 2015:213-8. doi: 10.14694/EdBook_AM.2015.35.213. PMID: 25993159

Prognosis

Biology and Management of Deep-seated Atypical Lipomatous Tumor of the Extremities.
Nishio J, Nakayama S, Chijiiwa Y, Aoki M
Anticancer Res 2023 Oct;43(10):4295-4301. doi: 10.21873/anticanres.16624. PMID: 37772567
Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
A Reappraisal of Superficial Pleomorphic Liposarcoma.
Berg SH, Massoud CM, Jackson-Cook C, Boikos SA, Smith SC, Mochel MC
Am J Clin Pathol 2020 Aug 5;154(3):353-361. doi: 10.1093/ajcp/aqaa045. PMID: 32525520
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Well-differentiated and dedifferentiated liposarcomas.
Coindre JM, Pédeutour F, Aurias A
Virchows Arch 2010 Feb;456(2):167-79. Epub 2009 Aug 18 doi: 10.1007/s00428-009-0815-x. PMID: 19688222

Clinical prediction guides

Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Lipomas of the Brachial Plexus: A Case Series and Review of the Literature.
Graf A, Yang K, King D, Dzwierzynski W, Sanger J, Hettinger P
Hand (N Y) 2019 May;14(3):333-338. Epub 2017 Oct 23 doi: 10.1177/1558944717735946. PMID: 29058949Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Hibernoma Mimicking Atypical Lipomatous Tumor: 64 Cases of a Morphologically Distinct Subset.
Al Hmada Y, Schaefer IM, Fletcher CDM
Am J Surg Pathol 2018 Jul;42(7):951-957. doi: 10.1097/PAS.0000000000001061. PMID: 29629919Free PMC Article
Atypical Spindle Cell Lipomatous Tumor: Clinicopathologic Characterization of 232 Cases Demonstrating a Morphologic Spectrum.
Mariño-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD
Am J Surg Pathol 2017 Feb;41(2):234-244. doi: 10.1097/PAS.0000000000000770. PMID: 27879515

Recent systematic reviews

Radiomics-based approaches outperform visual analysis for differentiating lipoma from atypical lipomatous tumors: a review.
Haidey J, Low G, Wilson MP
Skeletal Radiol 2023 Jun;52(6):1089-1100. Epub 2022 Nov 16 doi: 10.1007/s00256-022-04232-0. PMID: 36385583
Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.
Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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