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Sclerosing liposarcoma

MedGen UID:
137767
•Concept ID:
C0334469
•
Neoplastic Process
Synonyms: Sclerosing ALT/WDLPS; Sclerosing Atypical Lipomatous Tumor/Well Differentiated Liposarcoma; Sclerosing Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma; Sclerosing Liposarcoma; sclerosing liposarcoma
SNOMED CT: Sclerosing liposarcoma (404068003); Sclerosing liposarcoma (1162863006)
 
Monarch Initiative: MONDO:0003595

Definition

An atypical lipomatous tumor/well differentiated liposarcoma characterized by the presence of bizarre hyperchromatic stromal cells and rare multivacuolated lipoblasts within a fibrous stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosing liposarcoma

Recent clinical studies

Etiology

PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall.
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada CN, Wei S, Stevens TM
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):195-202. doi: 10.1097/PAI.0000000000000561. PMID: 28749793
Immunoreactivity of p53, mdm2, and p21WAF1 in dedifferentiated liposarcoma: special emphasis on the distinct immunophenotype of the well-differentiated component.
Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Masuda K, Tsuneyoshi M
Int J Surg Pathol 2001 Apr;9(2):99-109. doi: 10.1177/106689690100900203. PMID: 11484509
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases.
Dei Tos AP, Mentzel T, Newman PL, Fletcher CD
Am J Surg Pathol 1994 Sep;18(9):913-21. doi: 10.1097/00000478-199409000-00006. PMID: 8067512
Atypical and malignant neoplasms showing lipomatous differentiation. A study of 111 cases.
Azumi N, Curtis J, Kempson RL, Hendrickson MR
Am J Surg Pathol 1987 Mar;11(3):161-83. doi: 10.1097/00000478-198703000-00001. PMID: 3826477
Ultrastructural and histochemical identification of sclerosing liposarcoma.
Lazarus SS, Trombetta LD
Histopathology 1981 Mar;5(2):223-35. doi: 10.1111/j.1365-2559.1981.tb01780.x. PMID: 7216183

Diagnosis

Retroperitoneal liposarcoma and craniosynostosis: possible genomic relationship, case report, and literature review.
Sguinzi RM, Aissaoui S, Genevay-Infante M, Breguet R, Charbonnet P, Francis K, Kini R, Bühler L
Funct Integr Genomics 2022 Dec 20;23(1):8. doi: 10.1007/s10142-022-00924-x. PMID: 36538187
Esophageal spindle cell lipoma.
Val-Bernal JF, Mayorga MM, Fontanil N, Terán Á
Rom J Morphol Embryol 2021 Oct-Dec;62(4):1051-1055. doi: 10.47162/RJME.62.4.18. PMID: 35673825Free PMC Article
Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature.
Kikuchi N, Nakashima T, Fukushima J, Nariyama K, Komune S
J Laryngol Otol 2015 Mar;129 Suppl 2:S86-90. doi: 10.1017/S0022215114002461. PMID: 25706170
Primary liposarcoma of the heart.
Steger CM
BMJ Case Rep 2011 May 3;2011 doi: 10.1136/bcr.03.2011.4013. PMID: 22696697Free PMC Article
Primary liposarcoma of the stomach: a case report and a review of the literature.
Seki K, Hasegawa T, Konegawa R, Hizawa K, Sano T
Jpn J Clin Oncol 1998 Apr;28(4):284-8. doi: 10.1093/jjco/28.4.284. PMID: 9657017

Therapy

PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall.
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada CN, Wei S, Stevens TM
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):195-202. doi: 10.1097/PAI.0000000000000561. PMID: 28749793
Sclerosing lipogranuloma of male genitalia. Review of 23 cases.
Oertel YC, Johnson FB
Arch Pathol Lab Med 1977 Jun;101(6):321-6. PMID: 577132

Prognosis

Sclerosing liposarcoma of the anterior mediastinum: An unusual case.
Arava S, Breta M, Madan K, Nath D, Mehta S, Jain D
Indian J Pathol Microbiol 2016 Jan-Mar;59(1):69-71. doi: 10.4103/0377-4929.178226. PMID: 26960640
Nephron-sparing radical excision of a giant perirenal liposarcoma involving a solitary kidney.
Gaston KE, White RL Jr, Homsi S, Teigland C
Am Surg 2007 Apr;73(4):377-80. doi: 10.1177/000313480707300413. PMID: 17439032
Case report of vulvar liposarcoma.
AshrafGanjooie T
J Obstet Gynaecol Res 2004 Apr;30(2):80-3. doi: 10.1111/j.1447-0756.2003.00162.x. PMID: 15009607

Clinical prediction guides

Nephron-sparing radical excision of a giant perirenal liposarcoma involving a solitary kidney.
Gaston KE, White RL Jr, Homsi S, Teigland C
Am Surg 2007 Apr;73(4):377-80. doi: 10.1177/000313480707300413. PMID: 17439032
Pleomorphic lipoma of the oral cavity. Report of a case.
Perrotti V, Rubini C, Fioroni M, Iezzi G
Minerva Stomatol 2006 May;55(5):321-5. PMID: 16688109
Retroperitoneal liposarcoma with combined well-differentiated and myxoid malignant fibrous histiocytoma-like myxoid areas.
Hisaoka M, Morimitsu Y, Hashimoto H, Ishida T, Mukai H, Satoh H, Motoi T, Machinami R
Am J Surg Pathol 1999 Dec;23(12):1480-92. doi: 10.1097/00000478-199912000-00005. PMID: 10584701
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases.
Dei Tos AP, Mentzel T, Newman PL, Fletcher CD
Am J Surg Pathol 1994 Sep;18(9):913-21. doi: 10.1097/00000478-199409000-00006. PMID: 8067512
Myofibroblasts in soft tissue sarcomas.
Lagacé R, Schürch W, Seemayer TA
Virchows Arch A Pathol Anat Histol 1980;389(1):1-11. doi: 10.1007/BF00428664. PMID: 6256934

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