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Atypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue

MedGen UID:
1782669
•Concept ID:
C5447532
•
Neoplastic Process
Synonyms: ALT/WDLPS of Deep Soft Tissue; Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of Deep Soft Tissue; Well Differentiated Liposarcoma of Deep Soft Tissue; Well-Differentiated Liposarcoma of Deep Soft Tissue

Definition

An atypical lipomatous tumor/well differentiated liposarcoma that occurs in deep soft tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue

Professional guidelines

PubMed

Pleomorphic liposarcoma: Updates and current differential diagnosis.
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma.
Vassos N, Lell M, Hohenberger W, Croner RS, Agaimy A
Int J Clin Exp Pathol 2013;6(10):2178-84. Epub 2013 Sep 15 PMID: 24133596Free PMC Article
Buttock soft tissue sarcoma: clinical features, treatment, and prognosis.
Behranwala KA, Barry P, A'Hern R, Thomas JM
Ann Surg Oncol 2003 Oct;10(8):961-71. doi: 10.1245/aso.2003.12.001. PMID: 14527918

Recent clinical studies

Etiology

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.
Scalas G, Parmeggiani A, Martella C, Tuzzato G, Bianchi G, Facchini G, Clinca R, Spinnato P
Eur J Orthop Surg Traumatol 2021 Dec;31(8):1567-1575. Epub 2021 May 29 doi: 10.1007/s00590-021-03003-2. PMID: 34052920
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371
Giant Cervico-mediastinal Well-differentiated Liposarcoma.
Rena O, Davoli F, Pia F, Roncon A, Papalia E, Casadio C
Heart Lung Circ 2015 Jul;24(7):e112-4. Epub 2015 Mar 2 doi: 10.1016/j.hlc.2015.02.015. PMID: 25837020
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor.
Qorbani A, Horvai A
Surg Pathol Clin 2024 Mar;17(1):97-104. Epub 2023 Aug 23 doi: 10.1016/j.path.2023.07.004. PMID: 38278611
Pleomorphic liposarcoma: Updates and current differential diagnosis.
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371
Aggressive fibromatosis.
Fisher C, Thway K
Pathology 2014 Feb;46(2):135-40. doi: 10.1097/PAT.0000000000000045. PMID: 24378386
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

MRI radiomics-based machine learning for classification of deep-seated lipoma and atypical lipomatous tumor of the extremities.
Gitto S, Interlenghi M, Cuocolo R, Salvatore C, Giannetta V, Badalyan J, Gallazzi E, Spinelli MS, Gallazzi M, Serpi F, Messina C, Albano D, Annovazzi A, Anelli V, Baldi J, Aliprandi A, Armiraglio E, Parafioriti A, Daolio PA, Luzzati A, Biagini R, Castiglioni I, Sconfienza LM
Radiol Med 2023 Aug;128(8):989-998. Epub 2023 Jun 19 doi: 10.1007/s11547-023-01657-y. PMID: 37335422Free PMC Article
Investigation of radiomics and deep convolutional neural networks approaches for glioma grading.
Aouadi S, Torfeh T, Arunachalam Y, Paloor S, Riyas M, Hammoud R, Al-Hammadi N
Biomed Phys Eng Express 2023 Mar 23;9(3) doi: 10.1088/2057-1976/acc33a. PMID: 36898146
Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Clinical considerations of bleomycin based electrochemotherapy with variable electrode geometry electrodes for inoperable, deep-seated soft tissue sarcomas.
Ottlakan A, Lazar G, Hideghety K, Koszo RL, Deak B, Nagy A, Besenyi Z, Bottyan K, Vass GZ, Olah J, Kis EG
Bioelectrochemistry 2022 Dec;148:108220. Epub 2022 Aug 4 doi: 10.1016/j.bioelechem.2022.108220. PMID: 35987061
Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature.
Chambers M, Badin DJ, Sriharan AA, Linos KD
J Cutan Pathol 2020 Jun;47(6):554-560. Epub 2020 Feb 11 doi: 10.1111/cup.13650. PMID: 31995237

Prognosis

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.
Scalas G, Parmeggiani A, Martella C, Tuzzato G, Bianchi G, Facchini G, Clinca R, Spinnato P
Eur J Orthop Surg Traumatol 2021 Dec;31(8):1567-1575. Epub 2021 May 29 doi: 10.1007/s00590-021-03003-2. PMID: 34052920
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371
Recently characterized soft tissue tumors that bring biologic insight.
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes.
Schroeder BA, LaFranzo NA, LaFleur BJ, Gittelman RM, Vignali M, Zhang S, Flanagan KC, Rytlewski J, Riolobos L, Schulte BC, Kim TS, Chen E, Smythe KS, Wagner MJ, Mantilla JG, Campbell JS, Pierce RH, Jones RL, Cranmer LD, Pollack SM
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002812. PMID: 34465597Free PMC Article
Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.
Scalas G, Parmeggiani A, Martella C, Tuzzato G, Bianchi G, Facchini G, Clinca R, Spinnato P
Eur J Orthop Surg Traumatol 2021 Dec;31(8):1567-1575. Epub 2021 May 29 doi: 10.1007/s00590-021-03003-2. PMID: 34052920
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371
Recently characterized soft tissue tumors that bring biologic insight.
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856

Recent systematic reviews

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906

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