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Refractory Non-Hodgkin Lymphoma

MedGen UID:
163158
Concept ID:
C0854867
Neoplastic Process
Synonyms: Non-Hodgkin's Lymphoma Refractory; NonHodgkin's Lymphoma Refractory; Refractory Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma which does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY
Cancer Discov 2023 Mar 1;13(3):580-597. doi: 10.1158/2159-8290.CD-22-0964. PMID: 36416874Free PMC Article
Carreau NA, Armand P, Merryman RW, Advani RH, Spinner MA, Herrera AF, Ramchandren R, Hamid MS, Assouline S, Santiago R, Wagner-Johnston N, Paul S, Svoboda J, Bair SM, Barta SK, Nathan S, Karmali R, Torka P, David K, Lansigan F, Persky D, Godfrey J, Chavez JC, Xia Y, Diefenbach C
Br J Haematol 2020 Oct;191(1):44-51. Epub 2020 May 19 doi: 10.1111/bjh.16756. PMID: 32430944
Bacac M, Colombetti S, Herter S, Sam J, Perro M, Chen S, Bianchi R, Richard M, Schoenle A, Nicolini V, Diggelmann S, Limani F, Schlenker R, Hüsser T, Richter W, Bray-French K, Hinton H, Giusti AM, Freimoser-Grundschober A, Lariviere L, Neumann C, Klein C, Umaña P
Clin Cancer Res 2018 Oct 1;24(19):4785-4797. Epub 2018 May 1 doi: 10.1158/1078-0432.CCR-18-0455. PMID: 29716920

Recent clinical studies

Etiology

Pasvolsky O, Bassett RL, Ghanem S, Cuglievan B, Tewari P, Hosing C, Srour S, Ramdial J, Mahadeo KM, Khazal S, Petropoulos D, Popat U, Qazilbash M, Kebriaei P, Champlin R, Shpall EJ, Nieto Y
BMC Cancer 2023 Dec 20;23(1):1258. doi: 10.1186/s12885-023-11712-6. PMID: 38124057Free PMC Article
Carreau NA, Armand P, Merryman RW, Advani RH, Spinner MA, Herrera AF, Ramchandren R, Hamid MS, Assouline S, Santiago R, Wagner-Johnston N, Paul S, Svoboda J, Bair SM, Barta SK, Nathan S, Karmali R, Torka P, David K, Lansigan F, Persky D, Godfrey J, Chavez JC, Xia Y, Diefenbach C
Br J Haematol 2020 Oct;191(1):44-51. Epub 2020 May 19 doi: 10.1111/bjh.16756. PMID: 32430944
Kim DW, Lee G, Lee H, Mahal AR, Lam MB, Ng AK
Leuk Lymphoma 2020 Jun;61(6):1428-1434. Epub 2020 Feb 26 doi: 10.1080/10428194.2020.1719096. PMID: 32102580
Morschhauser F, Flinn IW, Advani R, Sehn LH, Diefenbach C, Kolibaba K, Press OW, Salles G, Tilly H, Chen AI, Assouline S, Cheson BD, Dreyling M, Hagenbeek A, Zinzani PL, Jones S, Cheng J, Lu D, Penuel E, Hirata J, Wenger M, Chu YW, Sharman J
Lancet Haematol 2019 May;6(5):e254-e265. Epub 2019 Mar 29 doi: 10.1016/S2352-3026(19)30026-2. PMID: 30935953
Davids MS, Roberts AW, Seymour JF, Pagel JM, Kahl BS, Wierda WG, Puvvada S, Kipps TJ, Anderson MA, Salem AH, Dunbar M, Zhu M, Peale F, Ross JA, Gressick L, Desai M, Kim SY, Verdugo M, Humerickhouse RA, Gordon GB, Gerecitano JF
J Clin Oncol 2017 Mar 10;35(8):826-833. Epub 2017 Jan 17 doi: 10.1200/JCO.2016.70.4320. PMID: 28095146Free PMC Article

Diagnosis

Suzuki M, Tsunoda S, Koyama D, Ikeda S, Sukegawa M, Hojo H, Ohta M
J Clin Exp Hematop 2021 Mar 18;61(1):22-28. Epub 2021 Feb 6 doi: 10.3960/jslrt.20051. PMID: 33551437Free PMC Article
Kambhampati S, Fakhri B, Ai WZ, Kaplan LD, Tuscano JM, Wieduwilt MJ, Sudhindra A, Cavallone E, Reiner J, Aoun C, Castillo M, Martinelli M, Ta T, Le D, Padilla M, Crawford E, Andreadis CB
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):139-146. Epub 2020 Dec 24 doi: 10.1016/j.clml.2020.12.020. PMID: 33478921
Tong C, Zhang Y, Liu Y, Ji X, Zhang W, Guo Y, Han X, Ti D, Dai H, Wang C, Yang Q, Liu W, Wang Y, Wu Z, Han W
Blood 2020 Oct 1;136(14):1632-1644. doi: 10.1182/blood.2020005278. PMID: 32556247Free PMC Article
Hughes ME, Landsburg DJ, Rubin DJ, Schuster SJ, Svoboda J, Gerson JN, Namoglu E, Nasta SD
Clin Lymphoma Myeloma Leuk 2019 Dec;19(12):791-798. Epub 2019 Sep 28 doi: 10.1016/j.clml.2019.09.612. PMID: 31648953
Witkowska M, Smolewski P, Robak T
Expert Opin Investig Drugs 2018 Feb;27(2):171-177. Epub 2018 Jan 15 doi: 10.1080/13543784.2018.1427730. PMID: 29323537

Therapy

Cichocki F, Zhang B, Wu CY, Chiu E, Day A, O'Connor RS, Yackoubov D, Simantov R, McKenna DH, Cao Q, Defor TE, Janakiram M, Wangen R, Cayci Z, Snyder N, Kumar A, Grzywacz B, Hwang J, Geffen Y, Miller JS, Maakaron J, Bachanova V
Sci Transl Med 2023 Jul 19;15(705):eade3341. doi: 10.1126/scitranslmed.ade3341. PMID: 37467318Free PMC Article
Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY
Cancer Discov 2023 Mar 1;13(3):580-597. doi: 10.1158/2159-8290.CD-22-0964. PMID: 36416874Free PMC Article
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Bröske AE, Korfi K, Belousov A, Wilson S, Ooi CH, Bolen CR, Canamero M, Alcaide EG, James I, Piccione EC, Carlile DJ, Dimier N, Umaña P, Bacac M, Weisser M, Dickinson M
Blood Adv 2022 Feb 8;6(3):1025-1037. doi: 10.1182/bloodadvances.2021005954. PMID: 34941996Free PMC Article
Bacac M, Colombetti S, Herter S, Sam J, Perro M, Chen S, Bianchi R, Richard M, Schoenle A, Nicolini V, Diggelmann S, Limani F, Schlenker R, Hüsser T, Richter W, Bray-French K, Hinton H, Giusti AM, Freimoser-Grundschober A, Lariviere L, Neumann C, Klein C, Umaña P
Clin Cancer Res 2018 Oct 1;24(19):4785-4797. Epub 2018 May 1 doi: 10.1158/1078-0432.CCR-18-0455. PMID: 29716920

Prognosis

Bröske AE, Korfi K, Belousov A, Wilson S, Ooi CH, Bolen CR, Canamero M, Alcaide EG, James I, Piccione EC, Carlile DJ, Dimier N, Umaña P, Bacac M, Weisser M, Dickinson M
Blood Adv 2022 Feb 8;6(3):1025-1037. doi: 10.1182/bloodadvances.2021005954. PMID: 34941996Free PMC Article
Tong C, Zhang Y, Liu Y, Ji X, Zhang W, Guo Y, Han X, Ti D, Dai H, Wang C, Yang Q, Liu W, Wang Y, Wu Z, Han W
Blood 2020 Oct 1;136(14):1632-1644. doi: 10.1182/blood.2020005278. PMID: 32556247Free PMC Article
Carreau NA, Armand P, Merryman RW, Advani RH, Spinner MA, Herrera AF, Ramchandren R, Hamid MS, Assouline S, Santiago R, Wagner-Johnston N, Paul S, Svoboda J, Bair SM, Barta SK, Nathan S, Karmali R, Torka P, David K, Lansigan F, Persky D, Godfrey J, Chavez JC, Xia Y, Diefenbach C
Br J Haematol 2020 Oct;191(1):44-51. Epub 2020 May 19 doi: 10.1111/bjh.16756. PMID: 32430944
Kim DW, Lee G, Lee H, Mahal AR, Lam MB, Ng AK
Leuk Lymphoma 2020 Jun;61(6):1428-1434. Epub 2020 Feb 26 doi: 10.1080/10428194.2020.1719096. PMID: 32102580
Morschhauser F, Flinn IW, Advani R, Sehn LH, Diefenbach C, Kolibaba K, Press OW, Salles G, Tilly H, Chen AI, Assouline S, Cheson BD, Dreyling M, Hagenbeek A, Zinzani PL, Jones S, Cheng J, Lu D, Penuel E, Hirata J, Wenger M, Chu YW, Sharman J
Lancet Haematol 2019 May;6(5):e254-e265. Epub 2019 Mar 29 doi: 10.1016/S2352-3026(19)30026-2. PMID: 30935953

Clinical prediction guides

Pasvolsky O, Bassett RL, Ghanem S, Cuglievan B, Tewari P, Hosing C, Srour S, Ramdial J, Mahadeo KM, Khazal S, Petropoulos D, Popat U, Qazilbash M, Kebriaei P, Champlin R, Shpall EJ, Nieto Y
BMC Cancer 2023 Dec 20;23(1):1258. doi: 10.1186/s12885-023-11712-6. PMID: 38124057Free PMC Article
Larson SM, Walthers CM, Ji B, Ghafouri SN, Naparstek J, Trent J, Chen JM, Roshandell M, Harris C, Khericha M, Schweppe T, Berent-Maoz B, Gosliner SB, Almaktari A, Ceja MA, Allen-Auerbach MS, Said J, Nawaly K, Mead M, de Vos S, Young PA, Oliai C, Schiller GJ, Timmerman JM, Ribas A, Chen YY
Cancer Discov 2023 Mar 1;13(3):580-597. doi: 10.1158/2159-8290.CD-22-0964. PMID: 36416874Free PMC Article
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Bröske AE, Korfi K, Belousov A, Wilson S, Ooi CH, Bolen CR, Canamero M, Alcaide EG, James I, Piccione EC, Carlile DJ, Dimier N, Umaña P, Bacac M, Weisser M, Dickinson M
Blood Adv 2022 Feb 8;6(3):1025-1037. doi: 10.1182/bloodadvances.2021005954. PMID: 34941996Free PMC Article
Davids MS, Roberts AW, Seymour JF, Pagel JM, Kahl BS, Wierda WG, Puvvada S, Kipps TJ, Anderson MA, Salem AH, Dunbar M, Zhu M, Peale F, Ross JA, Gressick L, Desai M, Kim SY, Verdugo M, Humerickhouse RA, Gordon GB, Gerecitano JF
J Clin Oncol 2017 Mar 10;35(8):826-833. Epub 2017 Jan 17 doi: 10.1200/JCO.2016.70.4320. PMID: 28095146Free PMC Article

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