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Refractory Transformed Mycosis Fungoides

MedGen UID:
1712362
•Concept ID:
C5237459
•
Neoplastic Process
Synonym: Refractory T-MF

Definition

Transformed mycosis fungoides that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Transformed Mycosis Fungoides

Professional guidelines

PubMed

Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Long-term efficacy and safety of alemtuzumab in advanced primary cutaneous T-cell lymphomas.
de Masson A, Guitera P, Brice P, Moulonguet I, Mouly F, Bouaziz JD, Battistella M, Madelaine I, Roux J, Ram-Wolff C, Cayuela JM, Bachelez H, Bensussan A, Michel L, Bagot M
Br J Dermatol 2014 Mar;170(3):720-4. doi: 10.1111/bjd.12690. PMID: 24438061
Prospective multicenter study of pegylated liposomal doxorubicin treatment in patients with advanced or refractory mycosis fungoides or Sézary syndrome.
Quereux G, Marques S, Nguyen JM, Bedane C, D'incan M, Dereure O, Puzenat E, Claudy A, Martin L, Joly P, Delaunay M, Beylot-Barry M, Vabres P, Celerier P, Sasolas B, Grange F, Khammari A, Dreno B
Arch Dermatol 2008 Jun;144(6):727-33. doi: 10.1001/archderm.144.6.727. PMID: 18559761

Recent clinical studies

Etiology

Evolution of Dupilumab-Associated Cutaneous Atypical Lymphoid Infiltrates.
Sokumbi O, Shamim H, Davis MDP, Wetter DA, Newman CC, Comfere N
Am J Dermatopathol 2021 Oct 1;43(10):714-720. doi: 10.1097/DAD.0000000000001875. PMID: 34132660
Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
Wieser I, Wang C, Alberti-Violetti S, Lyons G, Tran C, Talpur R, Duvic M
Arch Dermatol Res 2017 Aug;309(6):453-459. Epub 2017 May 17 doi: 10.1007/s00403-017-1744-1. PMID: 28516243
Folliculotropic mycosis fungoides: clinical and epidemiological evaluation in a single center in Brazil.
Deonizio JM, Ascef RD, Sanches JA
Int J Dermatol 2016 May;55(5):e256-61. Epub 2015 Dec 29 doi: 10.1111/ijd.13149. PMID: 26711732
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumab.
Kennedy GA, Seymour JF, Wolf M, Januszewicz H, Davison J, McCormack C, Ryan G, Prince HM
Eur J Haematol 2003 Oct;71(4):250-6. doi: 10.1034/j.1600-0609.2003.00143.x. PMID: 12950233

Diagnosis

Evolution of Dupilumab-Associated Cutaneous Atypical Lymphoid Infiltrates.
Sokumbi O, Shamim H, Davis MDP, Wetter DA, Newman CC, Comfere N
Am J Dermatopathol 2021 Oct 1;43(10):714-720. doi: 10.1097/DAD.0000000000001875. PMID: 34132660
Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
Wieser I, Wang C, Alberti-Violetti S, Lyons G, Tran C, Talpur R, Duvic M
Arch Dermatol Res 2017 Aug;309(6):453-459. Epub 2017 May 17 doi: 10.1007/s00403-017-1744-1. PMID: 28516243
Folliculotropic mycosis fungoides: clinical and epidemiological evaluation in a single center in Brazil.
Deonizio JM, Ascef RD, Sanches JA
Int J Dermatol 2016 May;55(5):e256-61. Epub 2015 Dec 29 doi: 10.1111/ijd.13149. PMID: 26711732
Preemptive leucovorin administration minimizes pralatrexate toxicity without sacrificing efficacy.
Koch E, Story SK, Geskin LJ
Leuk Lymphoma 2013 Nov;54(11):2448-51. Epub 2013 Apr 8 doi: 10.3109/10428194.2013.779688. PMID: 23442065Free PMC Article
Primary cutaneous T-cell lymphoma: review and current concepts.
Siegel RS, Pandolfino T, Guitart J, Rosen S, Kuzel TM
J Clin Oncol 2000 Aug;18(15):2908-25. doi: 10.1200/JCO.2000.18.15.2908. PMID: 10920140

Therapy

Pooled analysis of pralatrexate single-agent studies in patients with relapsed/refractory peripheral T-cell lymphoma.
O'Connor OA, Ko BS, Wang MC, Maruyama D, Song Y, Yeoh EM, Manamley N, Tobinai K
Blood Adv 2024 Jun 11;8(11):2601-2611. doi: 10.1182/bloodadvances.2023010441. PMID: 38429077Free PMC Article
Evolution of Dupilumab-Associated Cutaneous Atypical Lymphoid Infiltrates.
Sokumbi O, Shamim H, Davis MDP, Wetter DA, Newman CC, Comfere N
Am J Dermatopathol 2021 Oct 1;43(10):714-720. doi: 10.1097/DAD.0000000000001875. PMID: 34132660
Pembrolizumab in mycosis fungoides with PD-L1 structural variants.
Beygi S, Fernandez-Pol S, Duran G, Wang EB, Stehr H, Zehnder JL, Ramchurren N, Fling SP, Cheever MA, Weng WK, Kim YH, Khodadoust MS
Blood Adv 2021 Feb 9;5(3):771-774. doi: 10.1182/bloodadvances.2020002371. PMID: 33560388Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Bexarotene and DAB(389)IL-2 (denileukin diftitox, ONTAK) in treatment of cutaneous T-cell lymphomas: algorithms.
Duvic M
Clin Lymphoma 2000 Nov;1 Suppl 1:S51-5. doi: 10.3816/clm.2000.s.010. PMID: 11707865

Prognosis

Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
Wieser I, Wang C, Alberti-Violetti S, Lyons G, Tran C, Talpur R, Duvic M
Arch Dermatol Res 2017 Aug;309(6):453-459. Epub 2017 May 17 doi: 10.1007/s00403-017-1744-1. PMID: 28516243
Folliculotropic mycosis fungoides: clinical and epidemiological evaluation in a single center in Brazil.
Deonizio JM, Ascef RD, Sanches JA
Int J Dermatol 2016 May;55(5):e256-61. Epub 2015 Dec 29 doi: 10.1111/ijd.13149. PMID: 26711732
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Barr PM, Li H, Spier C, Mahadevan D, LeBlanc M, Ul Haq M, Huber BD, Flowers CR, Wagner-Johnston ND, Horwitz SM, Fisher RI, Cheson BD, Smith SM, Kahl BS, Bartlett NL, Friedberg JW
J Clin Oncol 2015 Jul 20;33(21):2399-404. Epub 2015 Jun 15 doi: 10.1200/JCO.2014.60.6327. PMID: 26077240Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study.
Foss F, Horwitz SM, Coiffier B, Bartlett N, Popplewell L, Pro B, Pinter-Brown LC, Shustov A, Furman RR, Haioun C, Koutsoukos T, O'Connor OA
Clin Lymphoma Myeloma Leuk 2012 Aug;12(4):238-43. Epub 2012 Apr 26 doi: 10.1016/j.clml.2012.01.010. PMID: 22542448

Clinical prediction guides

Evolution of Dupilumab-Associated Cutaneous Atypical Lymphoid Infiltrates.
Sokumbi O, Shamim H, Davis MDP, Wetter DA, Newman CC, Comfere N
Am J Dermatopathol 2021 Oct 1;43(10):714-720. doi: 10.1097/DAD.0000000000001875. PMID: 34132660
High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides.
de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS
Sci Transl Med 2018 May 9;10(440) doi: 10.1126/scitranslmed.aar5894. PMID: 29743350Free PMC Article
Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
Wieser I, Wang C, Alberti-Violetti S, Lyons G, Tran C, Talpur R, Duvic M
Arch Dermatol Res 2017 Aug;309(6):453-459. Epub 2017 May 17 doi: 10.1007/s00403-017-1744-1. PMID: 28516243
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Barr PM, Li H, Spier C, Mahadevan D, LeBlanc M, Ul Haq M, Huber BD, Flowers CR, Wagner-Johnston ND, Horwitz SM, Fisher RI, Cheson BD, Smith SM, Kahl BS, Bartlett NL, Friedberg JW
J Clin Oncol 2015 Jul 20;33(21):2399-404. Epub 2015 Jun 15 doi: 10.1200/JCO.2014.60.6327. PMID: 26077240Free PMC Article
Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumab.
Kennedy GA, Seymour JF, Wolf M, Januszewicz H, Davison J, McCormack C, Ryan G, Prince HM
Eur J Haematol 2003 Oct;71(4):250-6. doi: 10.1034/j.1600-0609.2003.00143.x. PMID: 12950233

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