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Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

MedGen UID:
1677524
Concept ID:
C4763396
Neoplastic Process

Definition

Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Professional guidelines

PubMed

Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Holdhoff M, Mrugala MM, Grommes C, Kaley TJ, Swinnen LJ, Perez-Heydrich C, Nayak L
J Natl Compr Canc Netw 2020 Nov;18(11):1571-1578. Epub 2020 Nov 2 doi: 10.6004/jnccn.2020.7667. PMID: 33152700
Grommes C, Nayak L, Tun HW, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):306-313. doi: 10.1093/neuonc/noy193. PMID: 30423172Free PMC Article

Recent clinical studies

Etiology

Conconi A, Chiappella A, Ferreri AJM, Stathis A, Botto B, Sassone M, Gaidano G, Balzarotti M, Merli F, Tucci A, Vanazzi A, Tani M, Bruna R, Orsucci L, Cabras MG, Celli M, Annibali O, Liberati AM, Zanni M, Ghiggi C, Pisani F, Pinotti G, Dore F, Esposito F, Pirosa MC, Cesaretti M, Bonomini L, Vitolo U, Zucca E
Blood Adv 2024 Mar 26;8(6):1541-1549. doi: 10.1182/bloodadvances.2023011251. PMID: 38181782Free PMC Article
Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Charalambous A, Schwarzbich MA, Witzens-Harig M
Recent Results Cancer Res 2018;212:133-168. doi: 10.1007/978-3-319-91439-8_7. PMID: 30069629
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Diagnosis

Epperla N, Kumar A, Abutalib SA, Awan FT, Chen YB, Gopal AK, Holter-Chakrabarty J, Kekre N, Lee CJ, Lekakis L, Lin Y, Mei M, Nathan S, Nastoupil L, Oluwole O, Phillips AA, Reid E, Rezvani AR, Trotman J, Zurko J, Kharfan-Dabaja MA, Sauter CS, Perales MA, Locke FL, Carpenter PA, Hamadani M
Transplant Cell Ther 2023 Sep;29(9):548-555. Epub 2023 Jul 5 doi: 10.1016/j.jtct.2023.06.012. PMID: 37419325
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
T Low J, B Peters K
CNS Oncol 2020 Mar 1;9(1):CNS51. Epub 2020 Mar 6 doi: 10.2217/cns-2019-0022. PMID: 32141313Free PMC Article
Charalambous A, Schwarzbich MA, Witzens-Harig M
Recent Results Cancer Res 2018;212:133-168. doi: 10.1007/978-3-319-91439-8_7. PMID: 30069629
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Therapy

Roschewski M, Hodson DJ
Haematologica 2024 Feb 1;109(2):388-400. doi: 10.3324/haematol.2021.278613. PMID: 37706315Free PMC Article
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK
Cancer Discov 2017 Sep;7(9):1018-1029. Epub 2017 Jun 15 doi: 10.1158/2159-8290.CD-17-0613. PMID: 28619981Free PMC Article
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Prognosis

Roschewski M, Hodson DJ
Haematologica 2024 Feb 1;109(2):388-400. doi: 10.3324/haematol.2021.278613. PMID: 37706315Free PMC Article
T Low J, B Peters K
CNS Oncol 2020 Mar 1;9(1):CNS51. Epub 2020 Mar 6 doi: 10.2217/cns-2019-0022. PMID: 32141313Free PMC Article
Ho KG, Grommes C
Curr Opin Neurol 2019 Dec;32(6):886-894. doi: 10.1097/WCO.0000000000000759. PMID: 31592789Free PMC Article
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644

Clinical prediction guides

Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Makita S, Yamamoto G, Maruyama D, Asano-Mori Y, Kaji D, Ananthakrishnan R, Ogasawara K, Stepan L, Schusterbauer C, Rettby N, Hasskarl J, Izutsu K
Cancer Med 2022 Dec;11(24):4889-4899. Epub 2022 May 26 doi: 10.1002/cam4.4820. PMID: 35619325Free PMC Article
Calimeri T, Steffanoni S, Foppoli M, Ponzoni M, Ferreri AJM
Expert Opin Ther Targets 2021 Sep;25(9):749-760. Epub 2021 Oct 26 doi: 10.1080/14728222.2021.1988927. PMID: 34606736
Ho KG, Grommes C
Curr Opin Neurol 2019 Dec;32(6):886-894. doi: 10.1097/WCO.0000000000000759. PMID: 31592789Free PMC Article
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644

Recent systematic reviews

Asghar N, Masood A, Dhaliwal A, Khurana S, Davis J, Hashmi H, Husnain M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):15-21. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.008. PMID: 36328891
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article

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