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Benign neoplasm of sweat gland

MedGen UID:
146888
•Concept ID:
C0684354
•
Neoplastic Process
Synonyms: Benign Neoplasm of Sweat Gland; benign neoplasm of sweat gland; Benign Neoplasm of the Sweat Gland; benign neoplasm of the sweat gland; Benign Sweat Gland Neoplasm; benign sweat gland neoplasm; Benign sweat gland tumor; Benign Sweat Gland Tumor; benign sweat gland tumor; benign sweat gland tumour; Benign Tumor of Sweat Gland; benign tumor of sweat gland; Benign Tumor of the Sweat Gland; benign tumor of the sweat gland; benign tumour of sweat gland; benign tumour of the sweat gland; sweat gland benign neoplasm; Sweat Gland Neoplasm, Benign; sweat gland neoplasm, benign; Sweat gland tumor, benign
SNOMED CT: Benign sweat gland tumor (81393009); Sweat gland tumor, benign (81393009); Benign neoplasm of sweat gland (92422009)
 
Monarch Initiative: MONDO:0021489

Definition

An epithelial neoplasm that arises from the sweat gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

CO(2) laser in the management of eccrine hidrocystomas: a retrospective study.
Fazia G, Cannarozzo G, Bennardo L, Nisticò SP
Lasers Med Sci 2022 Mar;37(2):1365-1369. Epub 2021 Sep 27 doi: 10.1007/s10103-021-03424-9. PMID: 34570293
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696
The differential diagnosis of syringoma and milia based on the imaging of reflectance confocal microscopy.
Gao M, Lin Y, Wang L, Yu Y, Zhou Y, Chen S, Lu X, Shan X, Liu H
Skin Res Technol 2020 Nov;26(6):951-953. Epub 2020 Jun 14 doi: 10.1111/srt.12879. PMID: 32537748

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Congenital syringocystadenoma papilliferum.
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179
Sweat gland carcinoma.
Hirsh LF, Enterline HT, Rosato EF, Rosato FE
Ann Surg 1971 Aug;174(2):283-6. doi: 10.1097/00000658-197108000-00015. PMID: 5560851Free PMC Article

Diagnosis

TRPS1 Expression in Endocrine Mucin-Producing Sweat Gland Carcinoma: Diagnostic Utility and Pitfalls.
Liu YA, Cho WC
Am J Dermatopathol 2024 Feb 1;46(2):133-135. Epub 2023 Dec 6 doi: 10.1097/DAD.0000000000002594. PMID: 38055965
Syringoid eccrine carcinoma.
Abedi SM, Yu R, Salama S, Alowami S
Cutis 2015 Sep;96(3):162,191-2. PMID: 26562272
Epidermotropic eccrine porocarcinoma.
Landa NG, Winkelmann RK
J Am Acad Dermatol 1991 Jan;24(1):27-31. doi: 10.1016/0190-9622(91)70004-l. PMID: 1999525
Eccrine porocarcinoma.
Gschnait F, Horn F, Lindlbauer R, Sponer D
J Cutan Pathol 1980 Dec;7(6):349-53. doi: 10.1111/j.1600-0560.1980.tb01208.x. PMID: 6256417
Hidrocystomas.
Smith JD, Chernosky ME
Arch Dermatol 1973 Nov;108(5):676-9. PMID: 4750204

Therapy

Gustatory Hyperhidrosis after Parotid Surgery.
Huang TR, Lee JC
N Engl J Med 2024 Sep 12;391(10):e21. Epub 2024 Sep 7 doi: 10.1056/NEJMicm2404232. PMID: 39248341
Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.
Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723Free PMC Article
Post-brachytherapy wound.
Gardner S
Br J Nurs 2017 Nov 8;26(Sup20a):S16-S17. doi: 10.12968/bjon.2017.26.Sup20a.S16. PMID: 29144783
Eccrine hidrocystomas.
Masri-Fridling GD, Elgart ML
J Am Acad Dermatol 1992 May;26(5 Pt 1):780-2. doi: 10.1016/s0190-9622(08)80561-0. PMID: 1583183
Surgical progress 1975.
Ellis H
Postgrad Med J 1976 Mar;52(605):113-29. doi: 10.1136/pgmj.52.605.113. PMID: 772646Free PMC Article

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Sweat Gland Tumor Microenvironment.
Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298
Congenital syringocystadenoma papilliferum.
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179
Rhabdomyomatous mesenchymal hamartoma.
Ortak T, Orbay H, Unlü E, Uysal C, Uraloğlu M, Sensöz OM
J Craniofac Surg 2005 Nov;16(6):1135-7. doi: 10.1097/01.scs.0000183468.93084.ba. PMID: 16327571
Sweat gland carcinoma.
Hirsh LF, Enterline HT, Rosato EF, Rosato FE
Ann Surg 1971 Aug;174(2):283-6. doi: 10.1097/00000658-197108000-00015. PMID: 5560851Free PMC Article

Clinical prediction guides

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Unilateral multiple plaque-like syringomas.
Rongioletti F, Semino MT, Rebora A
Br J Dermatol 1996 Oct;135(4):623-5. PMID: 8915160
Eccrine porocarcinoma.
Akiyoshi E, Nogita T, Yamaguchi R, Toyoda H, Kawashima M, Hidano A
Dermatologica 1991;182(4):239-42. doi: 10.1159/000247804. PMID: 1653154

Recent systematic reviews

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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