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Benign Apocrine Neoplasm

MedGen UID:
272352
•Concept ID:
C1332473
•
Neoplastic Process
Synonyms: Benign Apocrine Neoplasm of Skin; Benign Apocrine Neoplasm of the Skin; Benign Apocrine Skin Neoplasm; Benign Apocrine Skin Tumor; Benign Apocrine Tumor; Benign Apocrine Tumor of Skin; Benign Apocrine Tumor of the Skin

Definition

An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Apocrine Neoplasm

Professional guidelines

PubMed

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 May 11;22(10) doi: 10.3390/ijms22105077. PMID: 34064849Free PMC Article
Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis.
Zhang YF, Li H, Wang XM, Cai YF
Eur Radiol 2019 Feb;29(2):725-735. Epub 2018 Jul 10 doi: 10.1007/s00330-018-5609-6. PMID: 29992386Free PMC Article

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Challenges in the diagnosis of cutaneous adnexal tumours.
Danialan R, Mutyambizi K, Aung P, Prieto VG, Ivan D
J Clin Pathol 2015 Dec;68(12):992-1002. doi: 10.1136/jclinpath-2015-203228. PMID: 26602416

Diagnosis

Ceruminous Neoplasms of the Ear.
Nagarajan P
Head Neck Pathol 2018 Sep;12(3):350-361. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0909-3. PMID: 30069843Free PMC Article
Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls.
Asirvatham JR, Falcone MM, Kleer CG
Arch Pathol Lab Med 2016 Oct;140(10):1045-51. doi: 10.5858/arpa.2016-0238-RA. PMID: 27684975
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Malignant adnexal neoplasms.
Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719

Therapy

Conservative interventions for managing urinary incontinence after prostate surgery.
Johnson EE, Mamoulakis C, Stoniute A, Omar MI, Sinha S
Cochrane Database Syst Rev 2023 Apr 18;4(4):CD014799. doi: 10.1002/14651858.CD014799.pub2. PMID: 37070660Free PMC Article
Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome.
Stewart KL, Lephart ED
Int J Mol Sci 2023 Mar 13;24(6) doi: 10.3390/ijms24065486. PMID: 36982560Free PMC Article
Late-onset hypogonadism: Prostate safety.
Miranda EP, Torres LO
Andrology 2020 Nov;8(6):1606-1613. Epub 2020 Feb 28 doi: 10.1111/andr.12772. PMID: 32056383
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article
Cholesterol and benign prostate disease.
Freeman MR, Solomon KR
Differentiation 2011 Nov-Dec;82(4-5):244-52. Epub 2011 Aug 20 doi: 10.1016/j.diff.2011.04.005. PMID: 21862201Free PMC Article

Prognosis

An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Challenges in the diagnosis of cutaneous adnexal tumours.
Danialan R, Mutyambizi K, Aung P, Prieto VG, Ivan D
J Clin Pathol 2015 Dec;68(12):992-1002. doi: 10.1136/jclinpath-2015-203228. PMID: 26602416
Malignant adnexal neoplasms.
Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719
Eccrine angiomatous hamartoma.
Calderone DC, Glass LF, Seleznick M, Fenske NA
J Dermatol Surg Oncol 1994 Dec;20(12):837-8. doi: 10.1111/j.1524-4725.1994.tb03716.x. PMID: 7798419

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Molecular and diagnostic features of apocrine breast lesions.
Gromov P, Espinoza JA, Gromova I
Expert Rev Mol Diagn 2015;15(8):1011-22. Epub 2015 Jun 25 doi: 10.1586/14737159.2015.1057125. PMID: 26111757
Pitfalls in the staging of cancer of the major salivary gland neoplasms.
Friedman ER, Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):107-22. doi: 10.1016/j.nic.2012.08.009. PMID: 23199664

Recent systematic reviews

Conservative interventions for managing urinary incontinence after prostate surgery.
Johnson EE, Mamoulakis C, Stoniute A, Omar MI, Sinha S
Cochrane Database Syst Rev 2023 Apr 18;4(4):CD014799. doi: 10.1002/14651858.CD014799.pub2. PMID: 37070660Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Benign parotid mass and facial palsy: systematic review.
Stewart KE, Bannon R, Bannister M
Ann R Coll Surg Engl 2021 Jan;103(1):47-52. Epub 2020 Sep 24 doi: 10.1308/rcsann.2020.0194. PMID: 32969265Free PMC Article
Comparison of core needle biopsy and fine-needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta-analysis.
Cho J, Kim J, Lee JS, Chee CG, Kim Y, Choi SI
Head Neck 2020 Oct;42(10):3041-3050. Epub 2020 Jul 16 doi: 10.1002/hed.26377. PMID: 32671867
Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956

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