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Syringoma

MedGen UID:: 60205
•Concept ID:: C0206673
•: Neoplastic Process

Synonym:	Syringomas
SNOMED CT:	Syringoma (71244007); Syringoma of skin (302828001); Syringoma (302828001)

Monarch Initiative:	MONDO:0002191

Definition

A benign sweat gland neoplasm usually affecting the lower eyelids and upper cheeks. The lesions are papular and are usually numerous. Morphologically, there are nests, cords, and tubules of epithelial cells present, surrounded by a dense stroma in the reticular dermis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSyringoma

Neoplasm by Special Category
- Benign neoplasm
  - Benign epithelial neoplasm
    - Benign epithelial skin neoplasm
      - Benign neoplasm of sweat gland
        Benign eccrine neoplasm
        Syringoma
        Vulvar syringoma

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675

The differential diagnosis of syringoma and milia based on the imaging of reflectance confocal microscopy.

Gao M, Lin Y, Wang L, Yu Y, Zhou Y, Chen S, Lu X, Shan X, Liu H
Skin Res Technol 2020 Nov;26(6):951-953. Epub 2020 Jun 14 doi: 10.1111/srt.12879. PMID: 32537748

Generalized eruptive syringoma with poor clinical response to systemic treatment with acitretin.

Stawczyk-Macieja M, Szczerkowska-Dobosz A, Błażewicz I, Nowicki R, Biernat W
J Dtsch Dermatol Ges 2017 Mar;15(3):325-326. Epub 2017 Feb 8 doi: 10.1111/ddg.12800. PMID: 28177590

See all (13)

Recent clinical studies

Etiology

Generalized eruptive syringomas.

Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Syringoma: a clinicopathologic and immunohistologic study and results of treatment.

Lee JH, Chang JY, Lee KH
Yonsei Med J 2007 Feb 28;48(1):35-40. doi: 10.3349/ymj.2007.48.1.35. PMID: 17326243 Free PMC Article

Syringoid eccrine carcinoma.

Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Acral syringoma.

Hughes PS, Apisarnthanarax P
Arch Dermatol 1977 Oct;113(10):1435-6. PMID: 911173

See all (78)

Diagnosis

Generalized Eruptive Syringoma.

Wang Q, Liu J
J Cutan Med Surg 2024 May-Jun;28(3):313. Epub 2024 Feb 15 doi: 10.1177/12034754241229645. PMID: 38357853

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Familial eruptive syringoma.

Yaldiz M, Cosansu C, Erdem MT, Dikicier BS, Kahyaoglu Z
Hong Kong Med J 2018 Apr;24(2):200-202. doi: 10.12809/hkmj144415. PMID: 29658486

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Sarcoidosis simulating syringomas.

Rocha DS, Presotto C, Bringel DM, Bomm L, Balassiano E, Alves Mde F
An Bras Dermatol 2012 Mar-Apr;87(2):309-12. doi: 10.1590/s0365-05962012000200020. PMID: 22570040

See all (349)

Therapy

Botulinum toxin A as monotherapy for syringoma.

Zaldivar-Fujigaki JL, Achell Nava L
J Cosmet Dermatol 2021 May;20(5):1393-1395. Epub 2020 Dec 31 doi: 10.1111/jocd.13919. PMID: 33355994

Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.

Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007

Extensive Eruptive Syringoma After Liver Transplantation.

Maeda T, Natsuga K, Nishie W, Yamashita K, Shimizu H
Acta Derm Venereol 2018 Jan 12;98(1):119-120. doi: 10.2340/00015555-2814. PMID: 28971206

Carbon dioxide laser combined with botulinum toxin A for patients with periorbital syringomas.

Seo HM, Choi JY, Min J, Kim WS
J Cosmet Laser Ther 2016 Jun;18(3):149-53. Epub 2016 Mar 31 doi: 10.3109/14764172.2015.1052517. PMID: 26073121

Eruptive syringomas in the groin.

Litvinov IV, Jafarian F
CMAJ 2014 May 13;186(8):612. Epub 2013 Nov 18 doi: 10.1503/cmaj.130793. PMID: 24246582 Free PMC Article

See all (33)

Prognosis

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Myoepithelial Tumors: An Update.

Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065

Chondroid syringoma of the nasal dorsum.

Choi HJ, Son ET, Lee HJ
J Craniofac Surg 2015 Jan;26(1):e12-4. doi: 10.1097/SCS.0000000000001222. PMID: 25565228

An approach to clinical dermatologic diagnosis based on morphologic reaction patterns.

Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317

Syringoid eccrine carcinoma.

Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

See all (69)