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Tubular Sweat Gland Adenomas

MedGen UID:
1390908
•Concept ID:
C4505170
•
Neoplastic Process

Definition

Various tubular forms of benign tumors of the SWEAT GLAND with glandular differentiation. Common types include syringocystadenoma papilliferum of the head and neck, and hidradenoma papilliferum of the vulva area. Hidradenoma papilliferum may be derived from mammary-like glands of the vulva. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTubular Sweat Gland Adenomas

Professional guidelines

PubMed

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.
Pfarr N, Allgäuer M, Steiger K, Weichert W, Schirmacher P, Noske A, Stenzinger A
Pathology 2019 Jun;51(4):362-368. Epub 2019 Apr 19 doi: 10.1016/j.pathol.2019.01.010. PMID: 31010589

Recent clinical studies

Etiology

Contiguous squamous proliferations in syringocystadenoma papilliferum: A retrospective study of 14 cases.
Aggarwal D, Chatterjee D, Keshavamurthy V, Chhikara K, Saikia UN, Radotra BD, De D, Singh MP
Indian J Dermatol Venereol Leprol 2023 Jan-Mar;89(2):266-273. doi: 10.25259/IJDVL_845_20. PMID: 34623039
A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review.
McBride JD, Billings SD, Komforti MK
J Cutan Pathol 2021 Nov;48(11):1387-1391. Epub 2021 Jun 16 doi: 10.1111/cup.14080. PMID: 34089523
Vulval hidradenoma papilliferum: a clinical and dermoscopic study.
Tosti G, Salvini C, Barisani A, Grazi R, Pirola S, Cantisani C, Vaccari S, Madnani N
Clin Exp Dermatol 2020 Dec;45(8):1035-1039. Epub 2020 Oct 6 doi: 10.1111/ced.14254. PMID: 32356582
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry.
Friedman BJ, Sahu J, Solomides CC, Connolly DM, Lee JB
J Cutan Pathol 2018 Mar;45(3):212-216. Epub 2018 Jan 4 doi: 10.1111/cup.13093. PMID: 29206289
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841

Diagnosis

Syringocystadenoma Papilliferum in the External Ear Canal.
Jakovljevic S, Arsovic N, Boricic N, Laketic D, Dudvarski Z
Arch Iran Med 2022 Sep 1;25(9):658-660. doi: 10.34172/aim.2022.101. PMID: 37543891Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Syringocystadenoma papilliferum on the mons pubis.
Suzuki S, Al-Hajjaj S, Lee M, Bhawan J
Dermatol Online J 2018 Apr 14;24(4) PMID: 29906013
Syringocystadenoma Papilliferum of the External Auditory Canal.
Bruschini L, Ciabotti A, De Vito A, Forli F, Cambi C, Ciancia EM, Berrettini S
Am J Case Rep 2017 May 11;18:520-524. doi: 10.12659/ajcr.902900. PMID: 28490727Free PMC Article
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841

Therapy

Syringocystadenoma papilliferum associated with verrucous carcinoma of the skin in the same lesion: Report of four cases.
Alegría-Landa V, Jo-Velasco M, Santonja C, Eraña I, Vergara-Sanchez A, Kutzner H, Requena L
J Cutan Pathol 2020 Jan;47(1):12-16. Epub 2019 Sep 4 doi: 10.1111/cup.13572. PMID: 31449665

Prognosis

Syringocystadenocarcinoma of the perianal region: a case report.
Boujguenna I, Boukis F, Sefiani S, Ramraoui ME
J Med Case Rep 2024 Nov 29;18(1):579. doi: 10.1186/s13256-024-04927-z. PMID: 39614403Free PMC Article
Syringocystadenoma Papilliferum Revealed 12 Years After Surgical Treatment of Chronic Ear with Cholesteatoma: Presentation of an Unusual Case and Literature Review.
Zwierz A, Masna K, Burduk P
J Int Adv Otol 2022 Nov;18(6):544-547. doi: 10.5152/iao.2022.21594. PMID: 36349679Free PMC Article
Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases.
Zhang Y, Kong YY, Cai X, Shen XX, Kong JC
J Cutan Pathol 2017 Jun;44(6):538-543. Epub 2017 Apr 17 doi: 10.1111/cup.12934. PMID: 28337777
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841

Clinical prediction guides

Syringocystadenoma Papilliferum-Like Features in Poroma: An Unusual Morphologic Pattern of Poroma or True Synchronous Occurrence of 2 Distinct Neoplasms?
Alsawas M, Muhaj FF, Aung PP, Nagarajan P, Cho WC
Am J Dermatopathol 2024 Dec 1;46(12):871-874. Epub 2024 Oct 15 doi: 10.1097/DAD.0000000000002853. PMID: 39422612
Intradermal Syringocystadenoma Papilliferum on the Popliteal Fossa: A Rare Dermal Variant in an Atypical Location.
Omer M, Na S, Joshipura D, Robinson-Bostom L
R I Med J (2013) 2024 Jul 1;107(7):14-16. PMID: 38917308
Syringocystadenoma Papilliferum Revealed 12 Years After Surgical Treatment of Chronic Ear with Cholesteatoma: Presentation of an Unusual Case and Literature Review.
Zwierz A, Masna K, Burduk P
J Int Adv Otol 2022 Nov;18(6):544-547. doi: 10.5152/iao.2022.21594. PMID: 36349679Free PMC Article
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.
Pfarr N, Allgäuer M, Steiger K, Weichert W, Schirmacher P, Noske A, Stenzinger A
Pathology 2019 Jun;51(4):362-368. Epub 2019 Apr 19 doi: 10.1016/j.pathol.2019.01.010. PMID: 31010589
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691

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