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Schizophrenia Spectrum and Other Psychotic Disorders

MedGen UID:: 141907
•Concept ID:: C0525046
•: Mental or Behavioral Dysfunction

Synonym:

Schizophrenia and Disorders with Psychotic Features

Definition

Marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior), and deterioration from a previous level of functioning. Individuals have one o more of the following symptoms: delusions, hallucinations, and disorganized speech. (from DSM-5) [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSchizophrenia Spectrum and Other Psychotic Disorders

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Mental disorder
      - Schizophrenia Spectrum and Other Psychotic Disorders
        Affective psychosis
        Manic psychosis
        Capgras syndrome
        Delusional Parasitosis
        Morgellons Disease
        Paranoia
        Psychotic disorder
        Substance-induced psychosis
        Alcoholic psychosis
        Schizophrenia
        Catatonic schizophrenia
        Childhood-onset schizophrenia
        Chromosome 2p16.3 deletion syndrome
        Chronic schizophrenia
        Chronic residual schizophrenia
        Latent Chronic Schizophrenia
        Disorganized schizophrenia
        Folie à deux
        Latent schizophrenia
        Latent Subchronic Schizophrenia
        Paranoid schizophrenia
        Paraphrenia
        Residual schizophrenia
        Subchronic residual schizophrenia
        Schizophrenia 1
        Schizophrenia 2
        Schizophrenia 3
        Schizophrenia 4
        Schizophrenia 5
        Schizophrenia 6
        Schizophrenia 7
        Schizophrenia 8
        Schizophrenia 9
        Schizophrenia 10
        Schizophrenia 11
        Schizophrenia 12
        Schizophrenia 13
        Schizophrenia 14
        Schizophrenia 15
        Schizophrenia 16
        Schizophrenia 18
        Schizophrenia 19
        Simple schizophrenia
        Subchronic schizophrenia
        Treatment-refractory schizophrenia
        Undifferentiated schizophrenia

Professional guidelines

PubMed

Another Step Toward the Prediction of Antipsychotic Treatment Response Using Functional Connectivity.

Goff DC, Roffman J, Holt DJ
Am J Psychiatry 2023 Nov 1;180(11):787-788. doi: 10.1176/appi.ajp.20230731. PMID: 37908095

Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.

Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394

Depression and Schizophrenia: Sleep, Medical Risk Factors, Biomarkers, and Treatment.

Kalin NH
Am J Psychiatry 2021 Oct 1;178(10):881-884. doi: 10.1176/appi.ajp.2021.21080824. PMID: 34592847

See all (22)

Recent clinical studies

Etiology

Risk of Incident Psychosis and Mania With Prescription Amphetamines.

Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211

The Developmental Trajectory to Cannabis Use Disorder.

Hinckley JD, Ferland JN, Hurd YL
Am J Psychiatry 2024 May 1;181(5):353-358. doi: 10.1176/appi.ajp.20231006. PMID: 38706340 Free PMC Article

Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.

Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348 Free PMC Article

Neuroimaging Biomarkers in Schizophrenia.

Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140 Free PMC Article

Schizophrenia spectrum and other psychotic disorders.

Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

See all (99)

Diagnosis

Schizophrenia Spectrum Disorders and Psychosis.

Kalin NH
Am J Psychiatry 2024 Oct 1;181(10):847-850. doi: 10.1176/appi.ajp.20240733. PMID: 39350616

Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.

Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.

Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524 Free PMC Article

Neuroimaging Biomarkers in Schizophrenia.

Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140 Free PMC Article

Schizophrenia spectrum and other psychotic disorders.

Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

See all (82)

Therapy

Risk of Incident Psychosis and Mania With Prescription Amphetamines.

Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.

Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC
Am J Psychiatry 2022 Sep;179(9):611-627. Epub 2022 Jun 27 doi: 10.1176/appi.ajp.21101083. PMID: 35758639

Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.

Clozapine Intoxication in COVID-19.

Tio N, Schulte PFJ, Martens HJM
Am J Psychiatry 2021 Feb 1;178(2):123-127. doi: 10.1176/appi.ajp.2020.20071039. PMID: 33517757

See all (61)

Prognosis

Are We There Yet? Predicting Conversion to Psychosis Using Machine Learning.

Smucny J, Davidson I, Carter CS
Am J Psychiatry 2023 Nov 1;180(11):836-840. Epub 2023 Oct 4 doi: 10.1176/appi.ajp.20220973. PMID: 37789742 Free PMC Article

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.

Hindley G, Frei O, Shadrin AA, Cheng W, O'Connell KS, Icick R, Parker N, Bahrami S, Karadag N, Roelfs D, Holen B, Lin A, Fan CC, Djurovic S, Dale AM, Smeland OB, Andreassen OA
Am J Psychiatry 2022 Nov 1;179(11):833-843. Epub 2022 Sep 7 doi: 10.1176/appi.ajp.21101051. PMID: 36069018 Free PMC Article

Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.

Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524 Free PMC Article

Neuroimaging Biomarkers in Schizophrenia.

Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140 Free PMC Article

Schizophrenia spectrum and other psychotic disorders.

Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

See all (36)

Clinical prediction guides

Risk of Incident Psychosis and Mania With Prescription Amphetamines.

Are We There Yet? Predicting Conversion to Psychosis Using Machine Learning.

Smucny J, Davidson I, Carter CS
Am J Psychiatry 2023 Nov 1;180(11):836-840. Epub 2023 Oct 4 doi: 10.1176/appi.ajp.20220973. PMID: 37789742 Free PMC Article

Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.

Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.

Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524 Free PMC Article

Neuroimaging Biomarkers in Schizophrenia.

Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140 Free PMC Article

See all (55)

Recent systematic reviews

Prevalence of schizophrenia spectrum and other psychotic disorders in problem gambling: A systematic review and meta-analysis.

Corbeil O, Béchard L, Anderson É, Huot-Lavoie M, Desmeules C, Bachand L, Brodeur S, Carmichael PH, Jacques C, Solmi M, Dorval M, Giroux I, Roy MA, Demers MF
Eur Psychiatry 2024 Sep 25;67(1):e56. doi: 10.1192/j.eurpsy.2024.1777. PMID: 39320504 Free PMC Article

Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review.

Frileux S, Boltri M, Doré J, Leboyer M, Roux P
Neurosci Biobehav Rev 2024 Jul;162:105722. Epub 2024 May 15 doi: 10.1016/j.neubiorev.2024.105722. PMID: 38754717

The relationship between sleep and suicidality in schizophrenia spectrum and other psychotic disorders: A systematic review.

Rogers E, Gresswell M, Durrant S
Schizophr Res 2023 Nov;261:291-303. Epub 2023 Oct 23 doi: 10.1016/j.schres.2023.10.010. PMID: 37879227

The role of alcohol intake in the pharmacogenetics of treatment with clozapine.

Monroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M
Pharmacogenomics 2022 Apr;23(6):371-392. Epub 2022 Mar 21 doi: 10.2217/pgs-2022-0006. PMID: 35311547

Adiposity in schizophrenia: A systematic review and meta-analysis.

Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G, Hahn M, Agarwal SM
Acta Psychiatr Scand 2021 Dec;144(6):524-536. Epub 2021 Sep 16 doi: 10.1111/acps.13365. PMID: 34458979

See all (20)

MedGen

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Schizophrenia Spectrum and Other Psychotic Disorders

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity