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Paranoid schizophrenia

MedGen UID:
20664
•Concept ID:
C0036349
•
Mental or Behavioral Dysfunction
Synonyms: Paranoid Schizophrenia; Paranoid Schizophrenias; Schizophrenia, Paranoid; Schizophrenias, Paranoid
SNOMED CT: Paranoid schizophrenia (64905009); Paraphrenic schizophrenia (64905009)
 
Monarch Initiative: MONDO:0001484

Definition

A subtype of schizophrenia characterized by prominent delusions (typically persecutory or grandiose) or hallucinations in the context of a relative preservation of cognitive functioning and affect. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanoid schizophrenia

Professional guidelines

PubMed

Clinical and biological outcomes of prolonged treatment with haloperidol in schizophrenia.
Mutică M, Marinescu I, Militaru F, Pîrlog MC, Udriştoiu I
Rom J Morphol Embryol 2016;57(2):477-81. PMID: 27516021
Criteria for subtyping schizophrenia. Clinical differentiation of hebephrenic and paranoid schizophrenia.
Tsuang MT, Winokor G
Arch Gen Psychiatry 1974 Jul;31(1):43-7. doi: 10.1001/archpsyc.1974.01760130027004. PMID: 4599411
Manic-depressive illness and paranoid schizophrenia. A phenomenologic, family history, and treatment-response study.
Abrams R, Taylor MA, Gaztanaga P
Arch Gen Psychiatry 1974 Nov;31(5):640-2. doi: 10.1001/archpsyc.1974.01760170040006. PMID: 4441237

Recent clinical studies

Etiology

Psychotic disorders in DSM-5 and ICD-11.
Biedermann F, Fleischhacker WW
CNS Spectr 2016 Aug;21(4):349-54. Epub 2016 Jul 15 doi: 10.1017/S1092852916000316. PMID: 27418328
Caffeine-induced psychiatric manifestations: a review.
Wang HR, Woo YS, Bahk WM
Int Clin Psychopharmacol 2015 Jul;30(4):179-82. doi: 10.1097/YIC.0000000000000076. PMID: 25856116
Clinician safety.
Brasić JR, Fogelman D
Psychiatr Clin North Am 1999 Dec;22(4):923-40, x. doi: 10.1016/s0193-953x(05)70134-9. PMID: 10623979
Violence and paranoid schizophrenia.
Calcedo-Barba AL, Calcedo-Ordóñez A
Int J Law Psychiatry 1994 Summer;17(3):253-63. doi: 10.1016/0160-2527(94)90029-9. PMID: 7995685
Rape and homosexuality.
Cohen-Addad G
Med Law 1990;9(1):751-4. PMID: 2118217

Diagnosis

Morgellons in dermatology.
Harth W, Hermes B, Freudenmann RW
J Dtsch Dermatol Ges 2010 Apr;8(4):234-42. Epub 2009 Oct 29 doi: 10.1111/j.1610-0387.2009.07219.x. PMID: 19878403
Delusion assessment scales.
Forgácová L
Neuropsychopharmacol Hung 2008 Mar;10(1):23-30. PMID: 18771017
Neuropsychological aspects of delusional disorder.
Abdel-Hamid M, Brüne M
Curr Psychiatry Rep 2008 Jun;10(3):229-34. doi: 10.1007/s11920-008-0038-x. PMID: 18652791
Clinician safety.
Brasić JR, Fogelman D
Psychiatr Clin North Am 1999 Dec;22(4):923-40, x. doi: 10.1016/s0193-953x(05)70134-9. PMID: 10623979
Violence and paranoid schizophrenia.
Calcedo-Barba AL, Calcedo-Ordóñez A
Int J Law Psychiatry 1994 Summer;17(3):253-63. doi: 10.1016/0160-2527(94)90029-9. PMID: 7995685

Therapy

Caffeine-induced psychiatric manifestations: a review.
Wang HR, Woo YS, Bahk WM
Int Clin Psychopharmacol 2015 Jul;30(4):179-82. doi: 10.1097/YIC.0000000000000076. PMID: 25856116
Quetiapine-induced myoclonus.
Velayudhan L, Kirchner V
Int Clin Psychopharmacol 2005 Mar;20(2):119-20. doi: 10.1097/00004850-200503000-00011. PMID: 15729090
Olanzapine-induced neutropenia.
Gajwani P, Tesar GE
Psychosomatics 2000 Mar-Apr;41(2):150-1. doi: 10.1176/appi.psy.41.2.150. PMID: 10749954
Violence and paranoid schizophrenia.
Calcedo-Barba AL, Calcedo-Ordóñez A
Int J Law Psychiatry 1994 Summer;17(3):253-63. doi: 10.1016/0160-2527(94)90029-9. PMID: 7995685
Perphenazine-induced priapism.
Chan J, Alldredge BK, Baskin LS
DICP 1990 Mar;24(3):246-9. doi: 10.1177/106002809002400306. PMID: 2316231

Prognosis

Persistent delusional disorder with delusions of poverty - a case study.
Rodek P, Kucia K
Psychiatr Pol 2023 Oct 31;57(5):995-999. doi: 10.12740/PP/OnlineFirst/143044. PMID: 36370381
The de Clérambault syndrome: more than just a delusional disorder?
Sampogna G, Zinno F, Giallonardo V, Luciano M, Del Vecchio V, Fiorillo A
Int Rev Psychiatry 2020 Aug-Sep;32(5-6):385-390. Epub 2020 Apr 14 doi: 10.1080/09540261.2020.1744536. PMID: 32286086
Violence and paranoid schizophrenia.
Calcedo-Barba AL, Calcedo-Ordóñez A
Int J Law Psychiatry 1994 Summer;17(3):253-63. doi: 10.1016/0160-2527(94)90029-9. PMID: 7995685
Culture and schizophrenia.
Jablensky A, Sartorius N
Psychol Med 1975 May;5(2):113-24. doi: 10.1017/s003329170005635x. PMID: 1161950
Assessment or schizophrenia.
Cromwell RL
Annu Rev Psychol 1975;26:593-619. doi: 10.1146/annurev.ps.26.020175.003113. PMID: 1094933

Clinical prediction guides

Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors.
Leucht S, Leucht C, Huhn M, Chaimani A, Mavridis D, Helfer B, Samara M, Rabaioli M, Bächer S, Cipriani A, Geddes JR, Salanti G, Davis JM
Am J Psychiatry 2017 Oct 1;174(10):927-942. Epub 2017 May 25 doi: 10.1176/appi.ajp.2017.16121358. PMID: 28541090
Hemispheric lateralization in reasoning.
Turner BO, Marinsek N, Ryhal E, Miller MB
Ann N Y Acad Sci 2015 Nov;1359:47-64. Epub 2015 Oct 1 doi: 10.1111/nyas.12940. PMID: 26426534
Caffeine-induced psychiatric manifestations: a review.
Wang HR, Woo YS, Bahk WM
Int Clin Psychopharmacol 2015 Jul;30(4):179-82. doi: 10.1097/YIC.0000000000000076. PMID: 25856116
Olanzapine-induced respiratory failure.
Mouallem M, Wolf I
Am J Geriatr Psychiatry 2001 Summer;9(3):304-5. PMID: 11481140
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Recent systematic reviews

Treatments for primary delusional infestation.
Assalman I, Ahmed A, Alhajjar R, Bewley AP, Taylor R
Cochrane Database Syst Rev 2019 Dec 10;12(12):CD011326. doi: 10.1002/14651858.CD011326.pub2. PMID: 31821546Free PMC Article
A systematic review of the operational definitions for antipsychotic response in delusional disorder.
González-Rodríguez A, Estrada F, Monreal JA, Palao D, Labad J
Int Clin Psychopharmacol 2018 Sep;33(5):261-267. doi: 10.1097/YIC.0000000000000227. PMID: 29912058
A Systematic Review of Methods for the Measurement of Antipsychotic Adherence in Delusional Disorder.
González-Rodríguez A, Estrada F, Monreal JA, Palao D, Labad J
J Clin Psychopharmacol 2018 Aug;38(4):412-414. doi: 10.1097/JCP.0000000000000893. PMID: 29851708
Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors.
Leucht S, Leucht C, Huhn M, Chaimani A, Mavridis D, Helfer B, Samara M, Rabaioli M, Bächer S, Cipriani A, Geddes JR, Salanti G, Davis JM
Am J Psychiatry 2017 Oct 1;174(10):927-942. Epub 2017 May 25 doi: 10.1176/appi.ajp.2017.16121358. PMID: 28541090
Treatments for delusional disorder.
Skelton M, Khokhar WA, Thacker SP
Cochrane Database Syst Rev 2015 May 22;2015(5):CD009785. doi: 10.1002/14651858.CD009785.pub2. PMID: 25997589Free PMC Article

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