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Undifferentiated schizophrenia

MedGen UID:
140267
•Concept ID:
C0392322
•
Mental or Behavioral Dysfunction
Synonym: Schizophrenia, atypical
SNOMED CT: Atypical schizophrenia (111484002); Undifferentiated schizophrenia (111484002)

Definition

A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated schizophrenia

Professional guidelines

PubMed

Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Grover S, Chakrabarti S, Hazari N, Avasthi A
Psychiatry Res 2017 Mar;249:349-353. Epub 2017 Jan 18 doi: 10.1016/j.psychres.2017.01.042. PMID: 28152470
Weight Gain Risk Factor assessment checklist: overview and recommendation for use.
Treuer T, Pendlebury J, Lockman H, Bushe C, Karagianis J, Raskin J, Lipkovich I
Neuro Endocrinol Lett 2011;32(2):199-205. PMID: 21552187
Interactive risk factors for treatment adherence in a chronic psychotic disorders population.
Corriss DJ, Smith TE, Hull JW, Lim RW, Pratt SI, Romanelli S
Psychiatry Res 1999 Dec 27;89(3):269-74. doi: 10.1016/s0165-1781(99)00111-0. PMID: 10708273

Recent clinical studies

Etiology

Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia.
Gao Y, Liu X, Pan M, Zeng D, Zhou X, Tsunoda M, Zhang Y, Xie X, Wang R, Hu W, Li L, Yang H, Song Y
J Psychiatr Res 2022 Dec;156:628-638. Epub 2022 Nov 7 doi: 10.1016/j.jpsychires.2022.10.072. PMID: 36375230
A Preventive Role of RANTES Genetic Variation against Undifferentiated Schizophrenia.
Saoud H, Ben Afia A, Aflouk Y, Gaha L, Bel Hadj Jrad B
Immunol Invest 2022 Aug;51(6):1843-1855. Epub 2022 Apr 27 doi: 10.1080/08820139.2022.2067001. PMID: 35476033
Weight Gain Risk Factor assessment checklist: overview and recommendation for use.
Treuer T, Pendlebury J, Lockman H, Bushe C, Karagianis J, Raskin J, Lipkovich I
Neuro Endocrinol Lett 2011;32(2):199-205. PMID: 21552187
Gender-specific decline and seasonality of births in operationally defined schizophrenics in Italy.
Balestrieri M, Rucci P, Nicolaou S
Schizophr Res 1997 Oct 17;27(1):73-81. doi: 10.1016/S0920-9964(97)00071-6. PMID: 9373897
Subtype stability in schizophrenia.
Kendler KS, Gruenberg AM, Tsuang MT
Am J Psychiatry 1985 Jul;142(7):827-32. doi: 10.1176/ajp.142.7.827. PMID: 4014504

Diagnosis

Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia.
Gao Y, Liu X, Pan M, Zeng D, Zhou X, Tsunoda M, Zhang Y, Xie X, Wang R, Hu W, Li L, Yang H, Song Y
J Psychiatr Res 2022 Dec;156:628-638. Epub 2022 Nov 7 doi: 10.1016/j.jpsychires.2022.10.072. PMID: 36375230
Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences.
Benedetti F, Radaelli D, Poletti S, Falini A, Cavallaro R, Dallaspezia S, Riccaboni R, Scotti G, Smeraldi E
Psychol Med 2011 Mar;41(3):509-19. Epub 2010 Jun 9 doi: 10.1017/S0033291710001108. PMID: 20529416
Two cases of risperidone-induced tardive dyskinesia and a review of the literature.
Lykouras L, Yannakis R, Hatzimanolis J, Christodoulou GN
Eur Psychiatry 1999 Jul;14(4):245-7. doi: 10.1016/s0924-9338(99)80747-0. PMID: 10572353
Gender-specific decline and seasonality of births in operationally defined schizophrenics in Italy.
Balestrieri M, Rucci P, Nicolaou S
Schizophr Res 1997 Oct 17;27(1):73-81. doi: 10.1016/S0920-9964(97)00071-6. PMID: 9373897
Subtype stability in schizophrenia.
Kendler KS, Gruenberg AM, Tsuang MT
Am J Psychiatry 1985 Jul;142(7):827-32. doi: 10.1176/ajp.142.7.827. PMID: 4014504

Therapy

Postmortem studies on mitochondria in schizophrenia.
Roberts RC
Schizophr Res 2017 Sep;187:17-25. Epub 2017 Feb 9 doi: 10.1016/j.schres.2017.01.056. PMID: 28189530Free PMC Article
Weight Gain Risk Factor assessment checklist: overview and recommendation for use.
Treuer T, Pendlebury J, Lockman H, Bushe C, Karagianis J, Raskin J, Lipkovich I
Neuro Endocrinol Lett 2011;32(2):199-205. PMID: 21552187
Clozapine in the treatment of neuroleptic-induced blepharospasm: a report of 4 cases.
Levin H, Reddy R
J Clin Psychiatry 2000 Feb;61(2):140-3. doi: 10.4088/jcp.v61n0210. PMID: 10732662
Two cases of risperidone-induced tardive dyskinesia and a review of the literature.
Lykouras L, Yannakis R, Hatzimanolis J, Christodoulou GN
Eur Psychiatry 1999 Jul;14(4):245-7. doi: 10.1016/s0924-9338(99)80747-0. PMID: 10572353
Polydipsia and chronic hyponatremia in schizophrenic inpatients.
Kirch DG, Bigelow LB, Weinberger DR, Lawson WB, Wyatt RJ
J Clin Psychiatry 1985 May;46(5):179-81. PMID: 2859275

Prognosis

Weight Gain Risk Factor assessment checklist: overview and recommendation for use.
Treuer T, Pendlebury J, Lockman H, Bushe C, Karagianis J, Raskin J, Lipkovich I
Neuro Endocrinol Lett 2011;32(2):199-205. PMID: 21552187
Periodic lateralized epileptiform discharges in EEG during recovery from hyponatremia: a case report.
Itoh N, Matsui N, Matsui S
Clin Electroencephalogr 1994 Oct;25(4):164-9. doi: 10.1177/155005949402500411. PMID: 7813098
Early longitudinal course of acute-chronic and paranoid--undifferentiated schizophrenia subtypes and schizophreniform disorder.
Marengo JT, Harrow M, Westermeyer JF
J Abnorm Psychol 1991 Nov;100(4):600-3. doi: 10.1037//0021-843x.100.4.600. PMID: 1757674
Subtype stability in schizophrenia.
Kendler KS, Gruenberg AM, Tsuang MT
Am J Psychiatry 1985 Jul;142(7):827-32. doi: 10.1176/ajp.142.7.827. PMID: 4014504
Depression in the course of chronic undifferentiated schizophrenia.
Roy A
Arch Gen Psychiatry 1981 Mar;38(3):296-7. doi: 10.1001/archpsyc.1981.01780280064007. PMID: 7212960

Clinical prediction guides

Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Grover S, Chakrabarti S, Hazari N, Avasthi A
Psychiatry Res 2017 Mar;249:349-353. Epub 2017 Jan 18 doi: 10.1016/j.psychres.2017.01.042. PMID: 28152470
Psychiatric comorbidity in temporal DNET and improvement after surgery.
Landais A, Crespel A, Moulis JL, Coubes P, Gelisse P
Neurochirurgie 2016 Jun;62(3):165-70. Epub 2016 May 26 doi: 10.1016/j.neuchi.2016.02.002. PMID: 27237726
The validity of the DSM-IV diagnostic classification system of non-affective psychoses.
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ; GROUP
Aust N Z J Psychiatry 2011 Dec;45(12):1061-8. Epub 2011 Oct 25 doi: 10.3109/00048674.2011.620562. PMID: 22026404
Gender-specific decline and seasonality of births in operationally defined schizophrenics in Italy.
Balestrieri M, Rucci P, Nicolaou S
Schizophr Res 1997 Oct 17;27(1):73-81. doi: 10.1016/S0920-9964(97)00071-6. PMID: 9373897
Periodic lateralized epileptiform discharges in EEG during recovery from hyponatremia: a case report.
Itoh N, Matsui N, Matsui S
Clin Electroencephalogr 1994 Oct;25(4):164-9. doi: 10.1177/155005949402500411. PMID: 7813098

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