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Neoplasms, Bone Tissue

MedGen UID:: 104905
•Concept ID:: C0206639
•: Neoplastic Process

Synonyms:

Bone Tissue Neoplasm; Bone Tissue Neoplasms; Bony Tissue Neoplasm; Bony Tissue Neoplasms; Neoplasm, Bone Tissue; Neoplasm, Bony Tissue; Neoplasms, Bony Tissue; Tissue Neoplasm, Bone; Tissue Neoplasm, Bony; Tissue Neoplasms, Bone; Tissue Neoplasms, Bony

Definition

Neoplasms composed of bony tissue, whether normal or of a soft tissue which has become ossified. The concept does not refer to neoplasms located in bones. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplasms, Bone Tissue

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Connective and soft tissue neoplasm
        Connective tissue neoplasm
        Neoplasms, Bone Tissue
        Giant cell tumor of bone
        Ossifying fibroma
        Osteoblastoma
        Cementoma
        Maxillofacial Osteoblastoma
        Osteochondroma
        Multiple Osteochondromas
        Multiple congenital exostosis
        Solitary Osteochondroma
        Osteoma
        Enostosis
        Osteoid osteoma
        Maxillofacial Osteoid Osteoma
        Skull Osteoma
        Maxillofacial Osteoma
        Osteosarcoma
        Bone osteosarcoma
        Maxillofacial Osteosarcoma
        Metachronous osteosarcoma of the bone
        Primary Bone Osteosarcoma
        Secondary Osteosarcoma
        Ewing sarcoma
        Atypical Ewing Sarcoma
        Ewing sarcoma of bone
        Extraskeletal Ewing sarcoma
        Localized Ewing Sarcoma
        Metastatic Ewing Sarcoma
        Recurrent Ewing Sarcoma
        Refractory Ewing Sarcoma
        Unresectable Ewing Sarcoma
        Extraosseous osteosarcoma
        Adult extraskeletal osteosarcoma
        Breast extraskeletal osteosarcoma
        Cardiac Extraskeletal Osteosarcoma
        Central nervous system extraskeletal osteosarcoma
        Childhood extraosseous osteosarcoma
        Duodenal Extraskeletal Osteosarcoma
        Kidney osteogenic sarcoma
        Liver extraskeletal osteosarcoma
        Localized Extraskeletal Osteosarcoma
        Mediastinal extraskeletal osteosarcoma
        Metastatic Extraskeletal Osteosarcoma
        Prostate Osteosarcoma
        Recurrent Extraskeletal Osteosarcoma
        Juxtacortical osteosarcoma
        Childhood parosteal osteosarcoma
        Localized osteosarcoma
        Metastatic Osteosarcoma
        Locally Advanced Osteosarcoma
        Pediatric osteosarcoma
        Childhood intracortical osteosarcoma
        Childhood Periosteal Osteosarcoma
        Recurrent Osteosarcoma
        Refractory Osteosarcoma
        Resectable Osteosarcoma
        Unresectable Osteosarcoma

Professional guidelines

PubMed

Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era.

Goyal G, Heaney ML, Collin M, Cohen-Aubart F, Vaglio A, Durham BH, Hershkovitz-Rokah O, Girschikofsky M, Jacobsen ED, Toyama K, Goodman AM, Hendrie P, Cao XX, Estrada-Veras JI, Shpilberg O, Abdo A, Kurokawa M, Dagna L, McClain KL, Mazor RD, Picarsic J, Janku F, Go RS, Haroche J, Diamond EL
Blood 2020 May 28;135(22):1929-1945. doi: 10.1182/blood.2019003507. PMID: 32187362

Bone Cancer: Diagnosis and Treatment Principles.

Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968

The Diagnosis and Treatment of Prostate Cancer: A Review.

Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

See all (2364)

Recent clinical studies

Etiology

Sclerostin expression in skeletal sarcomas.

Shen J, Meyers CA, Shrestha S, Singh A, LaChaud G, Nguyen V, Asatrian G, Federman N, Bernthal N, Eilber FC, Dry SM, Ting K, Soo C, James AW
Hum Pathol 2016 Dec;58:24-34. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.016. PMID: 27498059 Free PMC Article

Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria.

Mohammed A, Sani MA, Hezekiah IA, Enoch AA
Afr J Paediatr Surg 2010 Jan-Apr;7(1):16-8. doi: 10.4103/0189-6725.59353. PMID: 20098003

Spinal tumors in children.

Binning M, Klimo P Jr, Gluf W, Goumnerova L
Neurosurg Clin N Am 2007 Oct;18(4):631-58. doi: 10.1016/j.nec.2007.07.001. PMID: 17991588

Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience.

Liu K, Tripp S, Layfield LJ
Pathol Res Pract 2007;203(9):633-40. doi: 10.1016/j.prp.2007.05.014. PMID: 17728073

Radiologic appearance of primary jaw lesions in children.

Gupta M, Kaste SC, Hopkins KP
Pediatr Radiol 2002 Mar;32(3):153-68. doi: 10.1007/s00247-001-0633-z. PMID: 12164347

See all (16)

Diagnosis

Benign bone tumors.

Steffner R
Cancer Treat Res 2014;162:31-63. doi: 10.1007/978-3-319-07323-1_3. PMID: 25070230

Primary tumors of the spine.

Orguc S, Arkun R
Semin Musculoskelet Radiol 2014 Jul;18(3):280-99. Epub 2014 Jun 4 doi: 10.1055/s-0034-1375570. PMID: 24896744

Benign bone tumors.

Motamedi K, Seeger LL
Radiol Clin North Am 2011 Nov;49(6):1115-34, v. doi: 10.1016/j.rcl.2011.07.002. PMID: 22024291

Osteosarcoma (osteogenic sarcoma).

Picci P
Orphanet J Rare Dis 2007 Jan 23;2:6. doi: 10.1186/1750-1172-2-6. PMID: 17244349 Free PMC Article

Benign bone tumors.

Temple HT, Scully SP, Aboulafia AJ
Instr Course Lect 2002;51:429-39. PMID: 12064131

See all (38)

Therapy

Occult phosphaturic mesenchymal tumour of femur cortex causing oncogenic osteomalacia - diagnostic challenges and clinical outcomes.

Dutta D, Pandey RK, Gogoi R, Solanki N, Madan R, Mondal A, Dogra S, Thapa P
Endokrynol Pol 2018;69(2):205-210. Epub 2018 Feb 14 doi: 10.5603/EP.a2018.0016. PMID: 29442350

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.

Peterse EFP, van den Akker BEWM, Niessen B, Oosting J, Suijker J, de Jong Y, Danen EHJ, Cleton-Jansen AM, Bovée JVMG
Mol Cancer Res 2017 Dec;15(12):1714-1721. Epub 2017 Aug 31 doi: 10.1158/1541-7786.MCR-17-0293. PMID: 28860121

Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection.

Weber MA, Sprengel SD, Omlor GW, Lehner B, Wiedenhöfer B, Kauczor HU, Rehnitz C
Skeletal Radiol 2015 Jul;44(7):981-93. Epub 2015 Apr 25 doi: 10.1007/s00256-015-2139-z. PMID: 25910709

Multidisciplinary management of primary tumors of the vertebral column.

Hsu W, Kosztowski TA, Zaidi HA, Dorsi M, Gokaslan ZL, Wolinsky JP
Curr Treat Options Oncol 2009 Apr;10(1-2):107-25. Epub 2009 Jun 23 doi: 10.1007/s11864-009-0102-8. PMID: 19548089

Tumors of the spine in children.

Rossi A, Gandolfo C, Morana G, Tortori-Donati P
Neuroimaging Clin N Am 2007 Feb;17(1):17-35. doi: 10.1016/j.nic.2006.11.004. PMID: 17493537

See all (8)

Prognosis

Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria.

Mohammed A, Sani MA, Hezekiah IA, Enoch AA
Afr J Paediatr Surg 2010 Jan-Apr;7(1):16-8. doi: 10.4103/0189-6725.59353. PMID: 20098003

Proliferation and apoptosis of tumour cells before and after neoadjuvant therapy for high-grade extremity sarcomas: divergent associations with tumour response and prognosis.

Matsubara T, Eimoto T, Okabe M, Miyabe S, Fujiyoshi Y, Matsushita Y, Mizutani J, Yamada S, Otsuka T
Histopathology 2008 May;52(6):706-16. Epub 2008 Apr 2 doi: 10.1111/j.1365-2559.2008.03015.x. PMID: 18393971

Osteosarcoma (osteogenic sarcoma).

Picci P
Orphanet J Rare Dis 2007 Jan 23;2:6. doi: 10.1186/1750-1172-2-6. PMID: 17244349 Free PMC Article

Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.

Szavcsur P, Godény M, Bajzik G, Lengyel E, Repa I, Trón L, Boér A, Vincze B, Póti Z, Szabolcs I, Esik O
Eur J Surg Oncol 2005 Mar;31(2):183-90. doi: 10.1016/j.ejso.2004.06.011. PMID: 15698736

Metaplastic breast carcinoma.

Smith DM, Rongaus VA, Wehmann TW, Agarwal PJ, Classen GJ
J Am Osteopath Assoc 1996 Jul;96(7):419-21. PMID: 8758875

See all (12)

Clinical prediction guides

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer.

Stopsack KH, Gerke T, Zareba P, Pettersson A, Chowdhury D, Ebot EM, Flavin R, Finn S, Kantoff PW, Stampfer MJ, Loda M, Fiorentino M, Mucci LA
Carcinogenesis 2020 Jul 14;41(7):904-908. doi: 10.1093/carcin/bgaa061. PMID: 32556091 Free PMC Article

Sclerostin expression in skeletal sarcomas.

Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection.

Weber MA, Sprengel SD, Omlor GW, Lehner B, Wiedenhöfer B, Kauczor HU, Rehnitz C
Skeletal Radiol 2015 Jul;44(7):981-93. Epub 2015 Apr 25 doi: 10.1007/s00256-015-2139-z. PMID: 25910709

Lactoferrin immuno-expression in human normal and neoplastic bone tissue.

Ieni A, Barresi V, Grosso M, Rosa MA, Tuccari G
J Bone Miner Metab 2009;27(3):364-71. Epub 2009 Feb 26 doi: 10.1007/s00774-009-0044-z. PMID: 19240970

Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience.

Liu K, Tripp S, Layfield LJ
Pathol Res Pract 2007;203(9):633-40. doi: 10.1016/j.prp.2007.05.014. PMID: 17728073

See all (14)

MedGen

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Neoplasms, Bone Tissue

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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