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Ossifying fibroma

MedGen UID:
104906
•Concept ID:
C0206640
•
Neoplastic Process
Synonyms: Fibroma, Ossifying; Fibromas, Ossifying; Ossifying Fibroma; Ossifying Fibromas
SNOMED CT: Cementifying fibroma (80699009); Cementifying fibroma, calcified structure (80699009); Ossifying fibroma, calcified structure (25603007); Ossifying fibroma (302862001); Ossifying fibroma (25603007); Fibro-osteoma (25603007); Fibro-osteoma (302862001); Cemento-ossifying fibroma (302863006)
 
HPO: HP:0030426
Monarch Initiative: MONDO:0002119

Definition

A benign central bone tumor composed of fibrous connective tissue within which bone is formed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOssifying fibroma

Professional guidelines

PubMed

Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management.
Koraitim M, Medra AM, Salloum AM, Shehata EA
J Craniofac Surg 2022 May 1;33(3):e265-e267. Epub 2021 Aug 13 doi: 10.1097/SCS.0000000000008085. PMID: 34387270
Diagnosis and management of benign fibro-osseous lesions of the jaws: a current review for the dental clinician.
Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498
Ossifying fibromas of the paranasal sinuses: diagnosis and management.
Ciniglio Appiani M, Verillaud B, Bresson D, Sauvaget E, Blancal JP, Guichard JP, Saint Maurice JP, Wassef M, Karligkiotis A, Kania R, Herman P
Acta Otorhinolaryngol Ital 2015 Oct;35(5):355-61. doi: 10.14639/0392-100X-533. PMID: 26824919Free PMC Article

Recent clinical studies

Etiology

Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Benign Fibro-Osseous Lesions of the Jaws.
Abramovitch K, Rice DD
Dent Clin North Am 2016 Jan;60(1):167-93. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.010. PMID: 26614954
Peripheral ossifying fibroma.
Luvizuto ER, Da Silva JB, Luvizuto GC, Pereira FP, Faco EF, Sedlacek P, Poi WR
J Craniofac Surg 2012 Jan;23(1):e7-10. doi: 10.1097/SCS.0b013e3182420729. PMID: 22337469
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Diagnosis

Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Bone-Related Lesions of the Jaws.
Baumhoer D
Surg Pathol Clin 2017 Sep;10(3):693-704. Epub 2017 Jun 2 doi: 10.1016/j.path.2017.04.007. PMID: 28797509
Benign Fibro-Osseous Lesions of the Jaws.
Abramovitch K, Rice DD
Dent Clin North Am 2016 Jan;60(1):167-93. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.010. PMID: 26614954
Peripheral ossifying fibroma.
Rallan M, Pathivada L, Rallan NS, Grover N
BMJ Case Rep 2013 May 20;2013 doi: 10.1136/bcr-2013-009010. PMID: 23696140Free PMC Article
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Therapy

Delayed Infection of Porous Polyethylene Implants After Oncologic Maxillectomy and Reconstruction: 2 Case Reports and Review of Literature.
Landry M, Hankins M, Berkovic J, Nathan CA
Ear Nose Throat J 2021 Dec;100(10_suppl):1023S-1026S. Epub 2020 Jun 15 doi: 10.1177/0145561320927525. PMID: 32538671
Unusual exophytic gingival lesion in a newborn treated with diode laser.
Tavares TS, da Costa AAS, Freire-Maia FB, Souza LN, Zarzar PM, Martins-Júnior PA, Aguiar MCF, Mesquita RA, Caldeira PC
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Sep;130(3):e74-e79. Epub 2020 Feb 25 doi: 10.1016/j.oooo.2020.01.007. PMID: 32107185
Oral and Extraoral Intermediate Tumors: Are MMP-9 and Ki-67 Biomarkers Correlated to Their High Recurrence Rates?
Afifi MM, Elnouaem MI, Omar EM, El-Komary I
Appl Immunohistochem Mol Morphol 2020 Mar;28(3):229-236. doi: 10.1097/PAI.0000000000000703. PMID: 30358613
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report.
González-Serrano J, López-Pintor RM, Sanz-Sánchez I, Paredes VM, Casañas E, de Arriba L, Vallejo GH
Int J Periodontics Restorative Dent 2017 May/Jun;37(3):443-449. doi: 10.11607/prd.2697. PMID: 28402358
Extensive neglected psammomatoid ossifying fibroma with craniofacial deformity.
Salyer KE, Barcelo CR, Por YC
J Craniofac Surg 2004 Nov;15(6):1033-9. doi: 10.1097/00001665-200411000-00031. PMID: 15547400

Prognosis

Skull Base Juvenile Psammomatoid Ossifying Fibroma: Clinical Characteristics, Treatment, and Prognosis.
Wang K, Ma XJ, Hao SY, Du J, Zhang LW, Zhang JT, Wu Z
World Neurosurg 2019 May;125:e843-e848. Epub 2019 Feb 8 doi: 10.1016/j.wneu.2019.01.197. PMID: 30743026
Diagnostically Challenging Epithelioid Soft Tissue Tumors.
James AW, Dry SM
Surg Pathol Clin 2015 Sep;8(3):309-29. doi: 10.1016/j.path.2015.05.002. PMID: 26297059
Ossifying fibroma of the jaws: a clinical study of 14 cases and review of the literature.
Triantafillidou K, Venetis G, Karakinaris G, Iordanidis F
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Aug;114(2):193-9. Epub 2012 Feb 25 doi: 10.1016/j.tripleo.2011.07.033. PMID: 22776732
Peripheral ossifying fibroma.
Luvizuto ER, Da Silva JB, Luvizuto GC, Pereira FP, Faco EF, Sedlacek P, Poi WR
J Craniofac Surg 2012 Jan;23(1):e7-10. doi: 10.1097/SCS.0b013e3182420729. PMID: 22337469
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Clinical prediction guides

Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement.
Cleven AHG, Szuhai K, van IJzendoorn DGP, Groen E, Baelde H, Schreuder WH, Briaire-de Bruijn IH, van der Meeren SW, Kleijwegt MC, Furth WR, Kroon HM, Suurmeijer AJH, Savci-Heijink DC, Baumhoer D, Bovée JVMG
Mod Pathol 2023 Jan;36(1):100013. doi: 10.1016/j.modpat.2022.100013. PMID: 36788065
Immunohistochemical Characterization of Gingival Fibromas.
Darling M, Li K, Burnside K, Smith N, Jackson-Boeters L, Hamilton D
Head Neck Pathol 2023 Jun;17(2):355-363. Epub 2022 Dec 6 doi: 10.1007/s12105-022-01493-y. PMID: 36472794Free PMC Article
SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.
Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
Benign Tumors of the Anterior Cranial Base.
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
Peripheral Cemento-Ossifying Fibroma.
Humagain M , Dawadi A , Srii R , Poudel P
Kathmandu Univ Med J (KUMJ) 2017 Jul-Sept.;15(59):261-264. PMID: 30353905

Recent systematic reviews

Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports.
R C, R S, Mohideen K, Balasubramaniam M, Ghosh S, Dhungel S
Clin Exp Dent Res 2023 Feb;9(1):186-197. Epub 2022 Nov 3 doi: 10.1002/cre2.687. PMID: 36325758Free PMC Article
Juvenile ossifying fibroma of the jaws and paranasal sinuses: a systematic review of the cases reported in the literature.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2020 Jan;49(1):28-37. Epub 2019 Jul 6 doi: 10.1016/j.ijom.2019.06.029. PMID: 31285096
Ossifying Fibromyxoid Tumor of the Retromolar Trigone: A Case Report and Systematic Review of the Literature.
Titsinides S, Nikitakis NG, Tasoulas J, Daskalopoulos A, Goutzanis L, Sklavounou A
Int J Surg Pathol 2017 Sep;25(6):526-532. Epub 2017 Apr 24 doi: 10.1177/1066896917705197. PMID: 28436288
Ossifying fibroma of the nose and paranasal sinuses.
Manes RP, Ryan MW, Batra PS, Mendelsohn D, Fang YV, Marple BF
Int Forum Allergy Rhinol 2013 Feb;3(2):161-8. Epub 2012 Jun 26 doi: 10.1002/alr.21067. PMID: 22736440
Ossifying fibroma: a systematic review.
MacDonald-Jankowski DS
Dentomaxillofac Radiol 2009 Dec;38(8):495-513. doi: 10.1259/dmfr/70933621. PMID: 20026707

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