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Recurrent Osteosarcoma

MedGen UID:
124509
•Concept ID:
C0278779
•
Neoplastic Process
Synonyms: Osteosarcoma, Recurrent; Recurrent Osteogenic Sarcoma; Relapsed Osteogenic Sarcoma; Relapsed Osteosarcoma

Definition

The reemergence of osteosarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Osteosarcoma

Professional guidelines

PubMed

Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcoma.
Meyers PA, Chou AJ
Adv Exp Med Biol 2014;804:307-21. doi: 10.1007/978-3-319-04843-7_17. PMID: 24924182
Strategies to explore new approaches in the investigation and treatment of osteosarcoma.
Kim SY, Helman LJ
Cancer Treat Res 2009;152:517-28. doi: 10.1007/978-1-4419-0284-9_31. PMID: 20213413
Liposomal muramyl tripeptide phosphatidylethanolamine: Targeting and activating macrophages for adjuvant treatment of osteosarcoma.
Nardin A, Lefebvre ML, Labroquère K, Faure O, Abastado JP
Curr Cancer Drug Targets 2006 Mar;6(2):123-33. doi: 10.2174/156800906776056473. PMID: 16529542

Recent clinical studies

Etiology

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Children's Oncology Group's 2023 blueprint for research: Bone tumors.
Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Phase 2 study of anti-disialoganglioside antibody, dinutuximab, in combination with GM-CSF in patients with recurrent osteosarcoma: A report from the Children's Oncology Group.
Hingorani P, Krailo M, Buxton A, Hutson P, Sondel PM, Diccianni M, Yu A, Morris CD, Womer RB, Crompton B, Randall RL, Teot LA, DuBois SG, Janeway KA, Gorlick RG, Isakoff MS
Eur J Cancer 2022 Sep;172:264-275. Epub 2022 Jul 6 doi: 10.1016/j.ejca.2022.05.035. PMID: 35809374Free PMC Article
Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcoma.
Meyers PA, Chou AJ
Adv Exp Med Biol 2014;804:307-21. doi: 10.1007/978-3-319-04843-7_17. PMID: 24924182

Diagnosis

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Kinnaman MD, Zaccaria S, Makohon-Moore A, Arnold B, Levine MF, Gundem G, Arango Ossa JE, Glodzik D, Rodríguez-Sánchez MI, Bouvier N, Li S, Stockfisch E, Dunigan M, Cobbs C, Bhanot UK, You D, Mullen K, Melchor JP, Ortiz MV, O'Donohue TJ, Slotkin EK, Wexler LH, Dela Cruz FS, Hameed MR, Glade Bender JL, Tap WD, Meyers PA, Papaemmanuil E, Kung AL, Iacobuzio-Donahue CA
Cancer Res 2023 Nov 15;83(22):3796-3812. doi: 10.1158/0008-5472.CAN-23-0385. PMID: 37812025Free PMC Article
Children's Oncology Group's 2023 blueprint for research: Bone tumors.
Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Survival after pulmonary metastasectomy for relapsed osteosarcoma.
Liu Z, Yin J, Zhou Q, Yang J, Zeng B, Yeung SJ, Shen J, Cheng C
J Thorac Cardiovasc Surg 2022 Feb;163(2):469-479.e8. Epub 2020 Nov 24 doi: 10.1016/j.jtcvs.2020.10.137. PMID: 33349447
Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
Li Z, Dou P, Liu T, He S
Cell Physiol Biochem 2017;42(4):1407-1419. Epub 2017 Jul 17 doi: 10.1159/000479205. PMID: 28715796
Gpnmb/osteoactivin: an indicator and therapeutic target in tumor and nontumorous lesions.
Zhuo H, Zhou L
Pharmazie 2016 Oct 1;71(10):555-561. doi: 10.1691/ph.2016.6683. PMID: 29441921

Therapy

Children's Oncology Group's 2023 blueprint for research: Bone tumors.
Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review.
Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM
Anticancer Res 2021 Dec;41(12):5865-5871. doi: 10.21873/anticanres.15406. PMID: 34848441
HER2-Targeted Therapy in Osteosarcoma.
Gill J, Hingorani P, Roth M, Gorlick R
Adv Exp Med Biol 2020;1257:55-66. doi: 10.1007/978-3-030-43032-0_5. PMID: 32483730
Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
Li Z, Dou P, Liu T, He S
Cell Physiol Biochem 2017;42(4):1407-1419. Epub 2017 Jul 17 doi: 10.1159/000479205. PMID: 28715796

Prognosis

Single-cell transcriptomics reveals the regulative roles of cancer associated fibroblasts in tumor immune microenvironment of recurrent osteosarcoma.
Huang X, Wang L, Guo H, Zhang W, Shao Z
Theranostics 2022;12(13):5877-5887. Epub 2022 Aug 1 doi: 10.7150/thno.73714. PMID: 35966586Free PMC Article
HER2-Targeted Therapy in Osteosarcoma.
Gill J, Hingorani P, Roth M, Gorlick R
Adv Exp Med Biol 2020;1257:55-66. doi: 10.1007/978-3-030-43032-0_5. PMID: 32483730
Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
Li Z, Dou P, Liu T, He S
Cell Physiol Biochem 2017;42(4):1407-1419. Epub 2017 Jul 17 doi: 10.1159/000479205. PMID: 28715796
Gpnmb/osteoactivin: an indicator and therapeutic target in tumor and nontumorous lesions.
Zhuo H, Zhou L
Pharmazie 2016 Oct 1;71(10):555-561. doi: 10.1691/ph.2016.6683. PMID: 29441921

Clinical prediction guides

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Kinnaman MD, Zaccaria S, Makohon-Moore A, Arnold B, Levine MF, Gundem G, Arango Ossa JE, Glodzik D, Rodríguez-Sánchez MI, Bouvier N, Li S, Stockfisch E, Dunigan M, Cobbs C, Bhanot UK, You D, Mullen K, Melchor JP, Ortiz MV, O'Donohue TJ, Slotkin EK, Wexler LH, Dela Cruz FS, Hameed MR, Glade Bender JL, Tap WD, Meyers PA, Papaemmanuil E, Kung AL, Iacobuzio-Donahue CA
Cancer Res 2023 Nov 15;83(22):3796-3812. doi: 10.1158/0008-5472.CAN-23-0385. PMID: 37812025Free PMC Article
Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Survival after pulmonary metastasectomy for relapsed osteosarcoma.
Liu Z, Yin J, Zhou Q, Yang J, Zeng B, Yeung SJ, Shen J, Cheng C
J Thorac Cardiovasc Surg 2022 Feb;163(2):469-479.e8. Epub 2020 Nov 24 doi: 10.1016/j.jtcvs.2020.10.137. PMID: 33349447
The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma.
Ying T, Dong JL, Yuan C, Li P, Guo Q
Biosci Rep 2020 Jan 31;40(1) doi: 10.1042/BSR20191251. PMID: 31850493Free PMC Article
High-dose ifosfamide in advanced osteosarcoma.
Marti C, Kroner T, Remagen W, Berchtold W, Cserhati M, Varini M
Cancer Treat Rep 1985 Jan;69(1):115-7. PMID: 3855382

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