|
| Status |
Public on Jan 12, 2018 |
| Title |
Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the first discovery of naturally occurring ESR1Y537C and ESR1Y537S mutations in MCF7 and SUM44 ESR1-positive cell-lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).
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| |
|
| Overall design |
RNAseq examination of gene expression changes due to long term estrogen deprivation in two breast cancer cell lines with and without ESR1 mutations
|
| |
|
| Contributor(s) |
Schuster E, Martin L |
| Citation(s) |
29192207 |
| |
| Submission date |
Jun 15, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Eugene Schuster |
| E-mail(s) |
[email protected]
|
| Phone |
+442088082619
|
| Organization name |
Institute of Cancer Research
|
| Department |
Breast Cancer Research
|
| Lab |
Endocrinology
|
| Street address |
123 Old Brompton Road
|
| City |
London |
| ZIP/Postal code |
SW7 3RP |
| Country |
United Kingdom |
| |
|
| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (15)
|
|
| This SubSeries is part of SuperSeries: |
| GSE100076 |
Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines |
|
| Relations |
| BioProject |
PRJNA390636 |
| SRA |
SRP109286 |
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