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    Ciz1 CDKN1A interacting zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 68379, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ciz1provided by MGI
    Official Full Name
    CDKN1A interacting zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:1920234
    See related
    Ensembl:ENSMUSG00000039205 AllianceGenome:MGI:1920234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LSFR1; ZNF356; 0610038H21Rik; 2900056O04Rik
    Summary
    Enables cyclin binding activity. Acts upstream of or within maintenance of protein location in nucleus and positive regulation of DNA-templated DNA replication initiation. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; heart; and immune system. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in ovary adult (RPKM 44.2), testis adult (RPKM 35.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ciz1 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32252724..32268311)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32363007..32378313)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52590 Neighboring gene predicted gene, 39787 Neighboring gene bublin coiled coil protein Neighboring gene lipocalin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome. Sofi S, et al. J Cell Biol, 2022 Apr 4. PMID 35289833, Free PMC Article
    2. Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture. Stewart ER, et al. Nat Commun, 2019 Jan 28. PMID 30692537, Free PMC Article
    3. DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. Khan MM, et al. Neurobiol Aging, 2018 Feb. PMID 29154038, Free PMC Article
    4. Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles. Dobbs OG, et al. BMC Biol, 2023 Aug 15. PMID 37580709, Free PMC Article
    5. Cardiomyocyte--specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart. Bageghni SA, et al. Biol Open, 2017 Jan 15. PMID 27934662, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.
      Title: Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.
    2. Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome.
      Title: Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome.
    3. Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
      Title: Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
    4. CDKN1A interacting zinc finger protein 1 (Ciz1) knockout mice (Ciz1(DeltaE5/DeltaE5) ) lose residues encoded by exon 5 but may gain function from novel amino acid sequences.
      Title: Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice.
    5. It plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint.
      Title: DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.
    6. CIZ1 is recruited to Xi in response to expression of X inactive-specific transcript (Xist) RNA during the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal nuclear matrix anchor domain of CIZ1 and the E repeats of Xist CIZ1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder.
      Title: The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.
    7. This study demonstrated that CIZ1 may be involved in the post-mitotic differentiation of neurons in response to external signals and changes in gene expression may compensate.
      Title: Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
    8. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins.
      Title: Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.
    9. results suggest that CIZ1 may play an important role in the progression of human prostate carcinoma and us which may be used as a therapeutic target in prostate cancer
      Title: Ciz1 promotes tumorigenicity of prostate carcinoma cells.
    10. CIZ1 functions as a tumor suppressor in vivo.
      Title: CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cip1-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252534.2 → NP_001239463.1  cip1-interacting zinc finger protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL808027
      UniProtKB/TrEMBL
      Q3TMV1, Q3TXU6
      Conserved Domains (5) summary
      smart00451
      Location:701 → 734
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 375
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:555 → 575
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:585 → 609
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:554 → 621
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    2. NM_001252536.2 → NP_001239465.1  cip1-interacting zinc finger protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL808027
      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:697 → 730
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:551 → 571
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:581 → 605
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:550 → 617
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    3. NM_001252537.2 → NP_001239466.1  cip1-interacting zinc finger protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
      Source sequence(s)
      AL808027
      Consensus CDS
      CCDS57166.1
      UniProtKB/TrEMBL
      Q3TMV1, Q3UUV0
      Related
      ENSMUSP00000108958.2, ENSMUST00000113332.8
      Conserved Domains (5) summary
      smart00451
      Location:692 → 725
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 413
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:546 → 566
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:576 → 600
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:545 → 612
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    4. NM_001252538.2 → NP_001239467.1  cip1-interacting zinc finger protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
      Source sequence(s)
      AL808027
      Consensus CDS
      CCDS57166.1
      UniProtKB/TrEMBL
      Q3TMV1, Q3UUV0
      Conserved Domains (5) summary
      smart00451
      Location:692 → 725
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 413
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:546 → 566
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:576 → 600
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:545 → 612
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    5. NM_028412.3 → NP_082688.1  cip1-interacting zinc finger protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL808027
      Consensus CDS
      CCDS15911.1
      UniProtKB/TrEMBL
      Q3TMV1, Q8VEH2
      Related
      ENSMUSP00000048428.8, ENSMUST00000048964.14
      Conserved Domains (6) summary
      smart00451
      Location:746 → 779
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 467
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:272 → 461
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:600 → 620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:630 → 654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:599 → 666
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32252724..32268311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498271.5 → XP_006498334.1  cip1-interacting zinc finger protein isoform X1

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:767 → 800
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:293 → 482
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:621 → 641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:133 → 555
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:651 → 675
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:620 → 687
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    2. XM_006498279.5 → XP_006498342.1  cip1-interacting zinc finger protein isoform X7

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:722 → 755
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 396
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:606 → 630
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:575 → 642
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    3. XM_006498280.5 → XP_006498343.1  cip1-interacting zinc finger protein isoform X8

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:718 → 751
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 392
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:572 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:602 → 626
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:571 → 638
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    4. XM_006498275.5 → XP_006498338.1  cip1-interacting zinc finger protein isoform X3

      UniProtKB/TrEMBL
      Q3TMV1, Q8VEH2
      Related
      ENSMUSP00000108964.3, ENSMUST00000113338.9
      Conserved Domains (6) summary
      smart00451
      Location:746 → 779
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 467
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:272 → 461
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:600 → 620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:630 → 654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:599 → 666
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    5. XM_006498282.5 → XP_006498345.1  cip1-interacting zinc finger protein isoform X10

      UniProtKB/TrEMBL
      Q3TMV1, Q3TXU6
      Conserved Domains (5) summary
      smart00451
      Location:701 → 734
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 375
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:555 → 575
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:585 → 609
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:554 → 621
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    6. XM_006498283.5 → XP_006498346.1  cip1-interacting zinc finger protein isoform X11

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:697 → 730
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:551 → 571
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:581 → 605
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:550 → 617
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    7. XM_006498274.5 → XP_006498337.1  cip1-interacting zinc finger protein isoform X2

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:762 → 795
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 483
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:288 → 477
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:616 → 636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:646 → 670
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:615 → 682
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    8. XM_006498277.5 → XP_006498340.1  cip1-interacting zinc finger protein isoform X5

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:741 → 774
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 462
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:595 → 615
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:625 → 649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:594 → 661
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    9. XM_030252020.2 → XP_030107880.1  cip1-interacting zinc finger protein isoform X12

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:696 → 729
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 370
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:550 → 570
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:580 → 604
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:549 → 616
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    10. XM_006498276.5 → XP_006498339.1  cip1-interacting zinc finger protein isoform X4

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:743 → 776
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:269 → 458
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:597 → 617
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:109 → 531
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:627 → 651
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:596 → 663
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    11. XM_006498278.5 → XP_006498341.1  cip1-interacting zinc finger protein isoform X6

      UniProtKB/TrEMBL
      A2AN61, Q3TMV1
      Related
      ENSMUSP00000108957.2, ENSMUST00000113331.8
      Conserved Domains (6) summary
      smart00451
      Location:722 → 755
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:248 → 437
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:130 → 510
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:606 → 630
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:575 → 642
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    12. XM_006498281.5 → XP_006498344.1  cip1-interacting zinc finger protein isoform X9

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:717 → 750
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:111 → 438
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:571 → 591
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:601 → 625
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:570 → 637
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    13. XM_036162520.1 → XP_036018413.1  cip1-interacting zinc finger protein isoform X14

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (6) summary
      smart00451
      Location:666 → 699
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 340
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:192 → 381
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:550 → 574
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:519 → 586
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    14. XM_030252025.2 → XP_030107885.1  cip1-interacting zinc finger protein isoform X18

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:600 → 633
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2 → 274
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:484 → 508
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:453 → 520
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    15. XM_030252016.2 → XP_030107876.1  cip1-interacting zinc finger protein isoform X2

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:762 → 795
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 483
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:288 → 477
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:616 → 636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:646 → 670
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:615 → 682
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    16. XM_006498273.5 → XP_006498336.1  cip1-interacting zinc finger protein isoform X1

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:767 → 800
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:293 → 482
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:621 → 641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:133 → 555
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:651 → 675
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:620 → 687
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    17. XM_006498272.5 → XP_006498335.1  cip1-interacting zinc finger protein isoform X1

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (6) summary
      smart00451
      Location:767 → 800
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:293 → 482
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:621 → 641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:133 → 555
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:651 → 675
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:620 → 687
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    18. XM_030252023.2 → XP_030107883.1  cip1-interacting zinc finger protein isoform X15

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (6) summary
      smart00451
      Location:645 → 678
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 319
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:171 → 360
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:529 → 553
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:498 → 565
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    19. XM_036162523.1 → XP_036018416.1  cip1-interacting zinc finger protein isoform X19

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:596 → 629
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 317
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:450 → 470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:480 → 504
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:449 → 516
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    20. XM_030252027.2 → XP_030107887.1  cip1-interacting zinc finger protein isoform X20

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:591 → 624
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 312
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:445 → 465
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:475 → 499
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:444 → 511
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    21. XM_030252019.2 → XP_030107879.1  cip1-interacting zinc finger protein isoform X11

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:697 → 730
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:551 → 571
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:581 → 605
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:550 → 617
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    22. XM_030252021.2 → XP_030107881.1  cip1-interacting zinc finger protein isoform X13

      UniProtKB/TrEMBL
      Q3TMV1, Q3UUV0
      Conserved Domains (5) summary
      smart00451
      Location:692 → 725
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 413
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:546 → 566
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:576 → 600
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:545 → 612
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    23. XM_030252018.2 → XP_030107878.1  cip1-interacting zinc finger protein isoform X10

      UniProtKB/TrEMBL
      Q3TMV1, Q3TXU6
      Conserved Domains (5) summary
      smart00451
      Location:701 → 734
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:103 → 375
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:555 → 575
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:585 → 609
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:554 → 621
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    24. XM_036162517.1 → XP_036018410.1  cip1-interacting zinc finger protein isoform X5

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:741 → 774
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 462
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:595 → 615
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:625 → 649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:594 → 661
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    25. XM_011239169.4 → XP_011237471.1  cip1-interacting zinc finger protein isoform X3

      UniProtKB/TrEMBL
      Q3TMV1, Q8VEH2
      Conserved Domains (6) summary
      smart00451
      Location:746 → 779
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 467
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:272 → 461
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:600 → 620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:630 → 654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:599 → 666
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    26. XM_036162519.1 → XP_036018412.1  cip1-interacting zinc finger protein isoform X14

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (6) summary
      smart00451
      Location:666 → 699
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 340
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:192 → 381
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:550 → 574
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:519 → 586
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    27. XM_036162522.1 → XP_036018415.1  cip1-interacting zinc finger protein isoform X18

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:600 → 633
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2 → 274
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:484 → 508
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:453 → 520
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    28. XM_030252026.2 → XP_030107886.1  cip1-interacting zinc finger protein isoform X19

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:596 → 629
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 317
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:450 → 470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:480 → 504
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:449 → 516
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    29. XM_030252024.1 → XP_030107884.1  cip1-interacting zinc finger protein isoform X15

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (6) summary
      smart00451
      Location:645 → 678
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 319
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:171 → 360
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:529 → 553
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:498 → 565
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    30. XM_036162521.1 → XP_036018414.1  cip1-interacting zinc finger protein isoform X16

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (5) summary
      smart00451
      Location:640 → 673
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:16 → 361
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:524 → 548
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:493 → 560
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    31. XM_036162518.1 → XP_036018411.1  cip1-interacting zinc finger protein isoform X5

      UniProtKB/TrEMBL
      Q3TMV1
      Conserved Domains (5) summary
      smart00451
      Location:741 → 774
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:46 → 462
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:595 → 615
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:625 → 649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:594 → 661
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily

    32. XM_006498285.4 → XP_006498348.1  cip1-interacting zinc finger protein isoform X17

      UniProtKB/TrEMBL
      Q70KX6
      Conserved Domains (6) summary
      smart00451
      Location:626 → 659
      ZnF_U1; U1-like zinc finger
      PRK10263
      Location:152 → 341
      PRK10263; DNA translocase FtsK; Provisional
      sd00020
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam03154
      Location:13 → 418
      Atrophin-1; Atrophin-1 family
      pfam12171
      Location:510 → 534
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl15257
      Location:479 → 546
      GIY-YIG_SF; GIY-YIG nuclease domain superfamily
    Nucleotide Protein Strain
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