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Conserved domains on  [gi|1720400492|ref|XP_030107887|]
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cip1-interacting zinc finger protein isoform X20 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 16-312 4.61e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 4.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPP--------------PVGVPINPSQLNHSGRNTQ 81
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapappavpagpatPGGPARPARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   82 KQARTPSSTTPNRKTVPledREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPE-PEPFETLEPPAKRCRSSEES 160
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRP---AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPPGPP 2846

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  161 TEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQAlqiQTQPkllrQAQTQTSPEHLAPQQDQVPTQA 240
Cdd:PHA03247  2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR---STES----FALPPDQPERPPQPQAPPPPQP 2919

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720400492  241 QSQEQTSEKTQDQPQTWPQGSVPPPEQAsGPACATEPQLSSHAAEAGSDPDKALPEPVSAQSSEDRSREASA 312
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 475-499 1.93e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*
gi 1720400492 475 FCTICNRYFKTPRKFVEHVKSQGHK 499
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 591-624 1.95e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 1.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720400492  591 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 624
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
GIY-YIG_SF super family cl15257
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large ...
 444-511 2.29e-03

GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large and diverse group of proteins involved in many cellular processes, such as class I homing GIY-YIG family endonucleases, prokaryotic nucleotide excision repair proteins UvrC and Cho, type II restriction enzymes, the endonuclease/reverse transcriptase of eukaryotic retrotransposable elements, and a family of eukaryotic enzymes that repair stalled replication forks. All of these members contain a conserved GIY-YIG nuclease domain that may serve as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. By combining with different specificity, targeting, or other domains, the GIY-YIG nucleases may perform different functions.


The actual alignment was detected with superfamily member cd10442:

Pssm-ID: 472790  Cd Length: 92  Bit Score: 37.73  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 444 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 511
Cdd:cd10442     6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 16-312 4.61e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 4.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPP--------------PVGVPINPSQLNHSGRNTQ 81
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapappavpagpatPGGPARPARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   82 KQARTPSSTTPNRKTVPledREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPE-PEPFETLEPPAKRCRSSEES 160
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRP---AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPPGPP 2846

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  161 TEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQAlqiQTQPkllrQAQTQTSPEHLAPQQDQVPTQA 240
Cdd:PHA03247  2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR---STES----FALPPDQPERPPQPQAPPPPQP 2919

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720400492  241 QSQEQTSEKTQDQPQTWPQGSVPPPEQAsGPACATEPQLSSHAAEAGSDPDKALPEPVSAQSSEDRSREASA 312
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 475-499 1.93e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*
gi 1720400492 475 FCTICNRYFKTPRKFVEHVKSQGHK 499
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 55-306 4.66e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  55 RQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPNRKTvPLEDREDPtegsEEATELQMDTcedqdSL--VGPDSM 132
Cdd:pfam09770 101 RFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT-GYEKYKEP----EPIPDLQVDA-----SLwgVAPKKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 133 LSEPQVPEPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQPQT--------QMTAPKQTQTPDRLPEPPEVQMLPRIQ 204
Cdd:pfam09770 171 AAPAPAPQPAAQPASLPAPSRKMMSLEEVEAAMRAQAKKPAQQPApapaqppaAPPAQQAQQQQQFPPQIQQQQQPQQQP 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 205 PQALQIQTQPKLLRQAQTQTSPEhLAPQQDQVPTQAQSQEQTSEKTQDQP---------QTWPQGSVPPPEQASGPACAT 275
Cdd:pfam09770 251 QQPQQHPGQGHPVTILQRPQSPQ-PDPAQPSIQPQAQQFHQQPPPVPVQPtqilqnpnrLSAARVGYPQNPQPGVQPAPA 329

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720400492 276 EPQLSSHAAEAGSDPDKALPEPVSAQSSEDR 306
Cdd:pfam09770 330 HQAHRQQGSFGRQAPIITHPQQLAQLSEEEK 360
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 591-624 1.95e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 1.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720400492  591 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 624
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
GIY-YIG_PLEs cd10442
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ...
 444-511 2.29e-03

Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.


Pssm-ID: 198389  Cd Length: 92  Bit Score: 37.73  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 444 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 511
Cdd:cd10442     6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 16-312 4.61e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 4.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPP--------------PVGVPINPSQLNHSGRNTQ 81
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapappavpagpatPGGPARPARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   82 KQARTPSSTTPNRKTVPledREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPE-PEPFETLEPPAKRCRSSEES 160
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRP---AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPPGPP 2846

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  161 TEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQAlqiQTQPkllrQAQTQTSPEHLAPQQDQVPTQA 240
Cdd:PHA03247  2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR---STES----FALPPDQPERPPQPQAPPPPQP 2919

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720400492  241 QSQEQTSEKTQDQPQTWPQGSVPPPEQAsGPACATEPQLSSHAAEAGSDPDKALPEPVSAQSSEDRSREASA 312
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-318 1.38e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492    2 PPATYDGASL-------TMPTATLGNLRAFNVTAPSLAAPSLTPPQMVTPnLQQFFPQATRQSLLGPPPVGVPINPSQLN 74
Cdd:PHA03247  2741 PPAVPAGPATpggparpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS-LSESRESLPSPWDPADPPAAVLAPAAALP 2819

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   75 HSGRNTQKQARTPSS--TTPNRKTVPLEDREdPTEGSEEATelqmdtcedqdslvGPDSMLSEPQVPEPEPFETLEPPAK 152
Cdd:PHA03247  2820 PAASPAGPLPPPTSAqpTAPPPPPGPPPPSL-PLGGSVAPG--------------GDVRRRPPSRSPAAKPAAPARPPVR 2884

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  153 RCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQAlQIQTQPKLLRQAQTQTSPE----- 227
Cdd:PHA03247  2885 RLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP-QPPLAPTTDPAGAGEPSGAvpqpw 2963

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  228 --HLAPQQDQVPTQAQSQEQTSEKTqdqpqtwPQGSVPPPEQASGPAcatepqLSSHAAEAGSDPDKAlPEPVS------ 299
Cdd:PHA03247  2964 lgALVPGRVAVPRFRVPQPAPSREA-------PASSTPPLTGHSLSR------VSSWASSLALHEETD-PPPVSlkqtlw 3029

                          330       340
                   ....*....|....*....|....
gi 1720400492  300 -----AQSSEDRSREASAGGLDLG 318
Cdd:PHA03247  3030 ppddtEDSDADSLFDSDSERSDLE 3053
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-300 5.85e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 5.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   38 PPQMVTPNLQqffPQATRQSLLGPPPVGVPINPSQlnhsgrnTQKQARTPSSTTPNRKTVPLEDREDPtEGSEEATELQM 117
Cdd:PHA03247  2551 PPPPLPPAAP---PAAPDRSVPPPRPAPRPSEPAV-------TSRARRPDAPPQSARPRAPVDDRGDP-RGPAPPSPLPP 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  118 DTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAK-----RCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLP 192
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  193 EPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPE-HLAPQQDQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGP 271
Cdd:PHA03247  2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAlPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                          250       260       270
                   ....*....|....*....|....*....|
gi 1720400492  272 A-CATEPQLSSHAAEAGSDPDKALPEPVSA 300
Cdd:PHA03247  2780 PrRLTRPAVASLSESRESLPSPWDPADPPA 2809
PRK10927 PRK10927
cell division protein FtsN;
139-306 1.76e-05

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 47.37  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 139 PEPEP----FETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQT---QTPDRLPEPPEVQMLPRIQPQALQIQ 211
Cdd:PRK10927   77 PKPEErwryIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQAdmrQQPTQLVEVPWNEQTPEQRQQTLQRQ 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 212 TQpkllRQAQTQTSPEHLAPQQDQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQ--ASGPACATEPQLSSHAAEAGSD 289
Cdd:PRK10927  157 RQ----AQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQdlLQTPAHTTAQSKPQQAAPVTRA 232

                         170
                  ....*....|....*..
gi 1720400492 290 PDKalPEPVSAQSSEDR 306
Cdd:PRK10927  233 ADA--PKPTAEKKDERR 247
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 475-499 1.93e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*
gi 1720400492 475 FCTICNRYFKTPRKFVEHVKSQGHK 499
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 93-306 1.85e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   93 NRKTVPLEDREDPTEGSEEATE----LQMDTCEDQDSLVGPDSMLSEPQVPEPEPfETLEP-----PAKRCRSSEESTEK 163
Cdd:PRK10263   297 NRATQPEYDEYDPLLNGAPITEpvavAAAATTATQSWAAPVEPVTQTPPVASVDV-PPAQPtvawqPVPGPQTGEPVIAP 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  164 GPTGQPQA--RVQPQTQMTAPKQTqtpdrlPEPPEVqmlPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVPTQAQ 241
Cdd:PRK10263   376 APEGYPQQsqYAQPAVQYNEPLQQ------PVQPQQ---PYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA 446

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720400492  242 SQeqtsekTQDQPQTWPQGSVPPPEQASGPACATEPQlsSHAAEAGSDPDKALPEPVSAQSSEDR 306
Cdd:PRK10263   447 WQ------AEEQQSTFAPQSTYQTEQTYQQPAAQEPL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 139-254 2.02e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 44.72  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 139 PEPEPFETLEPPAKRCRSSEESTEKGPT----GQPQARVQPQTQMTAPKQTQTPDRLP--EPPEVQMLPRIQPQALQIQT 212
Cdd:PRK14949  654 PASLSKPASSPDASQTSASFDLDPDFELathqSVPEAALASGSAPAPPPVPDPYDRPPweEAPEVASANDGPNNAAEGNL 733

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720400492 213 QPKLLRQAQTQTSP-EHLAPQQDQVPTQAQSQE------QTSEKTQDQP 254
Cdd:PRK14949  734 SESVEDASNSELQAvEQQATHQPQVQAEAQSPAsttaltQTSSEVQDTE 782
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 128-277 4.05e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  128 GPDSMLSEPQV-PEPEPFETLEPPAKrcrsseestekgpTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQ 206
Cdd:PRK10263   739 GPHEPLFTPIVePVQQPQQPVAPQQQ-------------YQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ 805

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720400492  207 ALQIQTQPKLLRQAQTQTSPEHLAPQQDQVPTQAQSQEQ-----TSEKTQDQPQTWPQGSVPPPEQASGPACATEP 277
Cdd:PRK10263   806 QPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTllhplLMRNGDSRPLHKPTTPLPSLDLLTPPPSEVEP 881
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 55-306 4.66e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  55 RQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPNRKTvPLEDREDPtegsEEATELQMDTcedqdSL--VGPDSM 132
Cdd:pfam09770 101 RFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT-GYEKYKEP----EPIPDLQVDA-----SLwgVAPKKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 133 LSEPQVPEPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQPQT--------QMTAPKQTQTPDRLPEPPEVQMLPRIQ 204
Cdd:pfam09770 171 AAPAPAPQPAAQPASLPAPSRKMMSLEEVEAAMRAQAKKPAQQPApapaqppaAPPAQQAQQQQQFPPQIQQQQQPQQQP 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 205 PQALQIQTQPKLLRQAQTQTSPEhLAPQQDQVPTQAQSQEQTSEKTQDQP---------QTWPQGSVPPPEQASGPACAT 275
Cdd:pfam09770 251 QQPQQHPGQGHPVTILQRPQSPQ-PDPAQPSIQPQAQQFHQQPPPVPVQPtqilqnpnrLSAARVGYPQNPQPGVQPAPA 329

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720400492 276 EPQLSSHAAEAGSDPDKALPEPVSAQSSEDR 306
Cdd:pfam09770 330 HQAHRQQGSFGRQAPIITHPQQLAQLSEEEK 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 29-290 1.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492   29 PSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSG-------RNTQKQARTPSSTTPNRKTVPLED 101
Cdd:PHA03247  2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPApgrvsrpRRARRLGRAAQASSPPQRPRRRAA 2688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  102 RedPTegseeatelqmdtcedqdslVGPDSMLSEPQVPEPEPfETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQM-- 179
Cdd:PHA03247  2689 R--PT--------------------VGSLTSLADPPPPPPTP-EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAvp 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  180 TAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQT-QPKLLRQAQTQTSPEHLAPQQDQVPTQAQSQEQTSEKTQDQPQTwP 258
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-P 2824

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1720400492  259 QGSVPPPEQA--SGPACATEPQLSSHAAEAGSDP 290
Cdd:PHA03247  2825 AGPLPPPTSAqpTAPPPPPGPPPPSLPLGGSVAP 2858
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 591-624 1.95e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 1.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720400492  591 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 624
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 195-306 2.24e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  195 PEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVPTQAQSQEQTSEKTQDQPQTwPQGSVPPPEQASGPaca 274
Cdd:PRK10263   751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVA-PQPQYQQPQQPVAP--- 826

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1720400492  275 tEPQLSSHAAEAGSDPDKALPEPVSAQSSEDR 306
Cdd:PRK10263   827 -QPQYQQPQQPVAPQPQDTLLHPLLMRNGDSR 857
GIY-YIG_PLEs cd10442
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ...
 444-511 2.29e-03

Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.


Pssm-ID: 198389  Cd Length: 92  Bit Score: 37.73  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 444 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 511
Cdd:cd10442     6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 128-316 2.71e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 128 GPDSMLSEPQVPEPEPFETLEPPAKRCR------SSEESTEKGPTGQPQARVQPQTQMTAPKQT---QTPDRLPEPPEVQ 198
Cdd:PRK07764  602 APASSGPPEEAARPAAPAAPAAPAAPAPagaaaaPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdgWPAKAGGAAPAAP 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 199 MLPRIQPQALQIQTQPKllRQAQTQTSPEHLAPQQDQVPTQAQSQEQTsektQDQPQTWPQGSVPPPEQASGPACATEPQ 278
Cdd:PRK07764  682 PPAPAPAAPAAPAGAAP--AQPAPAPAATPPAGQADDPAAQPPQAAQG----ASAPSPAADDPVPLPPEPDDPPDPAGAP 755

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1720400492 279 LSSHAAEAGSDPDKALPEP-VSAQSSEDRSREASAGGLD 316
Cdd:PRK07764  756 AQPPPPPAPAPAAAPAAAPpPSPPSEEEEMAEDDAPSMD 794
PRK12757 PRK12757
cell division protein FtsN; Provisional
 165-272 4.86e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 39.26  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 165 PTGQPQARVQPQ---------TQMTAPKQtQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPehlAPQQDQ 235
Cdd:PRK12757   68 PSAGGEVNSPTQltdeqrqllEQMQADMR-QQPTQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQP---QPVTPP 143

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720400492 236 VPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPA 272
Cdd:PRK12757  144 RQTTAPVQPQTPAPVRTQPAAPVTQAVEAPKVEAEKE 180
PRK10927 PRK10927
cell division protein FtsN;
148-268 6.37e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 39.28  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 148 EPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTpdRLPEPPEVQMLPRIQPQALQIQTQPKLLrQAQTQTSPE 227
Cdd:PRK10927  144 QTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQT--RTSQAAPVQAQPRQSKPASTQQPYQDLL-QTPAHTTAQ 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720400492 228 HLAPQQDQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQA 268
Cdd:PRK10927  221 SKPQQAAPVTRAADAPKPTAEKKDERRWMVQCGSFRGAEQA 261
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 159-294 6.53e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 159 ESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQAlqiQTQPKLLRQAQTQTSPEHLAPQQDQVPT 238
Cdd:PRK07764  379 ERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAA---APQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720400492 239 QAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEPQLSSH-AAEAGSDPDKAL 294
Cdd:PRK07764  456 PPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAApAAPAGADDAATL 512
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 10-383 9.21e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  10 SLTMPTATLGNLRAFNVTAPSLAAPSLTPPQMVTPnlqQFFPQATRQSLLGPPPVGVPINPSQLNHSGrntQKQARTPSS 89
Cdd:pfam03154 229 TLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSP---QPLPQPSLHGQMPPMPHSLQTGPSHMQHPV---PPQPFPLTP 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492  90 TTPNRKTVPLEDREDPTEGSEEATelqmdTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAkrcrsseeSTEKGPTGQP 169
Cdd:pfam03154 303 QSSQSQVPPGPSPAAPGQSQQRIH-----TPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPP--------TTPIPQLPNP 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 170 QARVQPqTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEhlAPQQDQVPTQAQSQEqtsek 249
Cdd:pfam03154 370 QSHKHP-PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPP--PPAQPPVLTQSQSLP----- 441

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400492 250 tqdqpqtwPQGSVPPPEQASGPAcATEPQLSSHAAEAGSDPDKALPE--PVSAQSSEDRSREASAGGLDLGecekragem 327
Cdd:pfam03154 442 --------PPAASHPPTSGLHQV-PSQSPFPQHPFVPGGPPPITPPSgpPTSTSSAMPGIQPPSSASVSSS--------- 503

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720400492 328 lGMWGAGSSLKVTILQSSNSRAFNTTPLTSGPRPGDSTSATPAIASTPS--KQSLQFF 383
Cdd:pfam03154 504 -GPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPShaSQSARFY 560
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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