|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10263 super family |
cl35903 |
DNA translocase FtsK; Provisional |
171-360 |
2.59e-07 |
|
DNA translocase FtsK; Provisional
The actual alignment was detected with superfamily member PRK10263:
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 54.32 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 171 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 250
Cdd:PRK10263 327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 251 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 330
Cdd:PRK10263 397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475
|
170 180 190
....*....|....*....|....*....|
gi 1720400483 331 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 360
Cdd:PRK10263 476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
16-319 |
5.28e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPnrk 95
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--- 2766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 96 dsSSQTVPledrEDPTEGSEEATElqmdtcedqdslVGPDSMLSEPQVPEPEPFETLEPPAKrcrSSEESTEKGPTGQPQ 175
Cdd:PHA03247 2767 --PAPAPP----AAPAAGPPRRLT------------RPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPA 2825
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 176 ARVQPQT--QMTAPKQTQTPDRLPEPPEVQMLP----RIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQP 249
Cdd:PHA03247 2826 GPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 250 PwqlqpRETDPPNQAQAqtqpqplwQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPP 319
Cdd:PHA03247 2906 E-----RPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
|
| zf-C2H2_jaz |
pfam12171 |
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ... |
529-553 |
1.81e-05 |
|
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
:
Pssm-ID: 432381 [Multi-domain] Cd Length: 27 Bit Score: 41.77 E-value: 1.81e-05
|
| ZnF_U1 |
smart00451 |
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ... |
645-678 |
1.74e-03 |
|
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.
:
Pssm-ID: 197732 [Multi-domain] Cd Length: 35 Bit Score: 36.46 E-value: 1.74e-03
10 20 30
....*....|....*....|....*....|....
gi 1720400483 645 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 678
Cdd:smart00451 3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
|
|
| GIY-YIG_SF super family |
cl15257 |
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large ... |
498-565 |
2.48e-03 |
|
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large and diverse group of proteins involved in many cellular processes, such as class I homing GIY-YIG family endonucleases, prokaryotic nucleotide excision repair proteins UvrC and Cho, type II restriction enzymes, the endonuclease/reverse transcriptase of eukaryotic retrotransposable elements, and a family of eukaryotic enzymes that repair stalled replication forks. All of these members contain a conserved GIY-YIG nuclease domain that may serve as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. By combining with different specificity, targeting, or other domains, the GIY-YIG nucleases may perform different functions.
The actual alignment was detected with superfamily member cd10442:
Pssm-ID: 472790 Cd Length: 92 Bit Score: 37.73 E-value: 2.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 498 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 565
Cdd:cd10442 6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
171-360 |
2.59e-07 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 54.32 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 171 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 250
Cdd:PRK10263 327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 251 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 330
Cdd:PRK10263 397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475
|
170 180 190
....*....|....*....|....*....|
gi 1720400483 331 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 360
Cdd:PRK10263 476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
16-319 |
5.28e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPnrk 95
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--- 2766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 96 dsSSQTVPledrEDPTEGSEEATElqmdtcedqdslVGPDSMLSEPQVPEPEPFETLEPPAKrcrSSEESTEKGPTGQPQ 175
Cdd:PHA03247 2767 --PAPAPP----AAPAAGPPRRLT------------RPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPA 2825
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 176 ARVQPQT--QMTAPKQTQTPDRLPEPPEVQMLP----RIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQP 249
Cdd:PHA03247 2826 GPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 250 PwqlqpRETDPPNQAQAqtqpqplwQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPP 319
Cdd:PHA03247 2906 E-----RPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
|
| zf-C2H2_jaz |
pfam12171 |
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ... |
529-553 |
1.81e-05 |
|
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Pssm-ID: 432381 [Multi-domain] Cd Length: 27 Bit Score: 41.77 E-value: 1.81e-05
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
132-299 |
4.92e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 46.95 E-value: 4.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 132 VGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTE-------KGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQM 204
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSRKMMSLEEVEaamraqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 205 LPRIQPQ----------ALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQ-------PRETDPPNQAQAQ 267
Cdd:pfam09770 245 QPQQQPQqpqqhpgqghPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQnpnrlsaARVGYPQNPQPGV 324
|
170 180 190
....*....|....*....|....*....|....*.
gi 1720400483 268 TQPQPLWQAQSQ----KQAQTQAHPQVPTQAQSQEQ 299
Cdd:pfam09770 325 QPAPAHQAHRQQgsfgRQAPIITHPQQLAQLSEEEK 360
|
|
| Agg_substance |
NF033875 |
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ... |
26-208 |
2.13e-04 |
|
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 45.09 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 26 VTAPSLAAPSLTPPQMVTPNLQQffpqatrqSLLGPPPVGVPINPSQLN-HSGRNTQKQARTPSSTTpnRKDSSSQTVPL 104
Cdd:NF033875 21 VVAPILFLGVLGVVGLATDNVQA--------AELDTQPGTTTVQPDNPDpQSGSETPKTAVSEEATV--QKDTTSQPTKV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 105 EDREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPEPEpfETLEPPAKrcrsseestekgPTGQPQARVQPQTQM 184
Cdd:NF033875 91 EEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSPE--TTNEPLGQ------------PTEVAPAENEANKST 156
|
170 180
....*....|....*....|....
gi 1720400483 185 TAPKQTQTPDRLPEPPEVQMLPRI 208
Cdd:NF033875 157 SIPKEFETPDVDKAVDEAKKDPNI 180
|
|
| ZnF_U1 |
smart00451 |
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ... |
645-678 |
1.74e-03 |
|
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.
Pssm-ID: 197732 [Multi-domain] Cd Length: 35 Bit Score: 36.46 E-value: 1.74e-03
10 20 30
....*....|....*....|....*....|....
gi 1720400483 645 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 678
Cdd:smart00451 3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
29-437 |
1.93e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 29 PSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQarTPSSTTPNRKDSSSQTVPLEDRE 108
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQ--TPTLHPQRLPSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 109 DPTEGSEEATElqmdtcedQDSLVGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTEKGP-------TGQPQARVQPQ 181
Cdd:pfam03154 257 PPSQVSPQPLP--------QPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPpgpspaaPGQSQQRIHTP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 182 TQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQpklLRQAQTQTSPEHL-APQQDQVEPQVPsqPPWQLQPRETDP 260
Cdd:pfam03154 329 PSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQ---LPNPQSHKHPPHLsGPSPFQMNSNLP--PPPALKPLSSLS 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 261 PNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEqtsektqdqpqtwPQGSVPPPEQASGPAcATEPQLSSHAAEA 340
Cdd:pfam03154 404 THHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLP-------------PPAASHPPTSGLHQV-PSQSPFPQHPFVP 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 341 GSDPDKALPE--PVSAQSSEDRSREASAGGLDLGecekragemlGMWGAGSSLKVTILQSSNSRAFNTTPLTSGPRPGDS 418
Cdd:pfam03154 470 GGPPPITPPSgpPTSTSSAMPGIQPPSSASVSSS----------GPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
410 420
....*....|....*....|.
gi 1720400483 419 TSATPAIASTPS--KQSLQFF 437
Cdd:pfam03154 540 PSPEPTVVNTPShaSQSARFY 560
|
|
| GIY-YIG_PLEs |
cd10442 |
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ... |
498-565 |
2.48e-03 |
|
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.
Pssm-ID: 198389 Cd Length: 92 Bit Score: 37.73 E-value: 2.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 498 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 565
Cdd:cd10442 6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
171-360 |
2.59e-07 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 54.32 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 171 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 250
Cdd:PRK10263 327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 251 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 330
Cdd:PRK10263 397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475
|
170 180 190
....*....|....*....|....*....|
gi 1720400483 331 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 360
Cdd:PRK10263 476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
26-366 |
3.69e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 3.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 26 VTAPSLAAPSLTPPQMVTPNLQQFfPQATRQSLLGPPPVGVPINPsqlnhsgRNTQKQARTPSSTTPNRKDSSSQTVPLe 105
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARP-TVGSLTSLADPPPPPPTPEP-------APHALVSATPLPPGPAAARQASPALPA- 2737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 106 DREDPTEGSEEATELQMDTCEDQDSLVGPDSMlSEPQVPEPEPFETLEPPAkrCRSSEESTEKGPTgqPQARVQPQTQMT 185
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAP-APPAAPAAGPPRRLTRPA--VASLSESRESLPS--PWDPADPPAAVL 2812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 186 APKQTQTPDRLP---EPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSP--EHLAPQQDQVEPQVPSQPPWQLQPRETDP 260
Cdd:PHA03247 2813 APAAALPPAASPagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVS 2892
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 261 PNQAQAQTQPQPLwQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQtwpqgsvPPPEQASGPACATEPQLSSHAAEA 340
Cdd:PHA03247 2893 RSTESFALPPDQP-ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ-------PPLAPTTDPAGAGEPSGAVPQPWL 2964
|
330 340
....*....|....*....|....*.
gi 1720400483 341 GSDPDKALPEPVSAQSSEDRSREASA 366
Cdd:PHA03247 2965 GALVPGRVAVPRFRVPQPAPSREAPA 2990
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
16-319 |
5.28e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 16 ATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPnrk 95
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--- 2766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 96 dsSSQTVPledrEDPTEGSEEATElqmdtcedqdslVGPDSMLSEPQVPEPEPFETLEPPAKrcrSSEESTEKGPTGQPQ 175
Cdd:PHA03247 2767 --PAPAPP----AAPAAGPPRRLT------------RPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPA 2825
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 176 ARVQPQT--QMTAPKQTQTPDRLPEPPEVQMLP----RIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQP 249
Cdd:PHA03247 2826 GPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 250 PwqlqpRETDPPNQAQAqtqpqplwQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPP 319
Cdd:PHA03247 2906 E-----RPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
153-371 |
6.79e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.60 E-value: 6.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 153 EPPAKRCRSSEESTEKGPtGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPE 232
Cdd:PRK07764 591 APGAAGGEGPPAPASSGP-PEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 233 HLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQpqplWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQ----DQP 308
Cdd:PRK07764 670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPA----ATPPAGQADDPAAQPPQAAQGASAPSPAADDPvplpPEP 745
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720400483 309 QTWPQGSVPPPEQASGPACATEPQLSSHAAEA-GSDPDKALPEPVSAQSSEDRsREASAGGLDL 371
Cdd:PRK07764 746 DDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSpPSEEEEMAEDDAPSMDDEDR-RDAEEVAMEL 808
|
|
| PRK14949 |
PRK14949 |
DNA polymerase III subunits gamma and tau; Provisional |
83-308 |
7.29e-06 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237863 [Multi-domain] Cd Length: 944 Bit Score: 49.72 E-value: 7.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 83 QARTPSSTTPNRKDSSSQTVPLEDREDPTEGSEEATELQMDTCEDQD----SLVGPDSMLSEpqVPEPEPFETLEPpakr 158
Cdd:PRK14949 564 YNALSDDEQHSANVQSAQSAAEAQPSSQSLSPISAVTTAAASLADDDildaVLAARDSLLSD--LDALSPKEGDGK---- 637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 159 cRSSEESTEKGPTGQPQARVQPQTQmTAPKQTQTPDRLPEPPEVQMLPR--IQPQALQIQTQPKLLRQAQTQTSPEHLAP 236
Cdd:PRK14949 638 -KSSADRKPKTPPSRAPPASLSKPA-SSPDASQTSASFDLDPDFELATHqsVPEAALASGSAPAPPPVPDPYDRPPWEEA 715
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720400483 237 QQDQVEPQVPSQPPwqlqpRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQP 308
Cdd:PRK14949 716 PEVASANDGPNNAA-----EGNLSESVEDASNSELQAVEQQATHQPQVQAEAQSPASTTALTQTSSEVQDTE 782
|
|
| PRK10927 |
PRK10927 |
cell division protein FtsN; |
144-322 |
9.46e-06 |
|
cell division protein FtsN;
Pssm-ID: 236797 [Multi-domain] Cd Length: 319 Bit Score: 48.14 E-value: 9.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 144 PEPEP----FETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQT---QTPDRLPEPPEVQMLPRIQPQALQIQ 216
Cdd:PRK10927 77 PKPEErwryIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQAdmrQQPTQLVEVPWNEQTPEQRQQTLQRQ 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 217 TQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRetdPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPT--QA 294
Cdd:PRK10927 157 RQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPR---QSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVtrAA 233
|
170 180
....*....|....*....|....*...
gi 1720400483 295 QSQEQTSEKTQDQPQTWPQGSVPPPEQA 322
Cdd:PRK10927 234 DAPKPTAEKKDERRWMVQCGSFRGAEQA 261
|
|
| zf-C2H2_jaz |
pfam12171 |
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ... |
529-553 |
1.81e-05 |
|
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Pssm-ID: 432381 [Multi-domain] Cd Length: 27 Bit Score: 41.77 E-value: 1.81e-05
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
132-299 |
4.92e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 46.95 E-value: 4.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 132 VGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTE-------KGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQM 204
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSRKMMSLEEVEaamraqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 205 LPRIQPQ----------ALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQ-------PRETDPPNQAQAQ 267
Cdd:pfam09770 245 QPQQQPQqpqqhpgqghPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQnpnrlsaARVGYPQNPQPGV 324
|
170 180 190
....*....|....*....|....*....|....*.
gi 1720400483 268 TQPQPLWQAQSQ----KQAQTQAHPQVPTQAQSQEQ 299
Cdd:pfam09770 325 QPAPAHQAHRQQgsfgRQAPIITHPQQLAQLSEEEK 360
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
199-319 |
1.71e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.08 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 199 PPEVQMLPRIQPQAlqiQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQaqtqpqplwQAQS 278
Cdd:PRK10263 740 PHEPLFTPIVEPVQ---QPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ---------YQQP 807
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1720400483 279 QKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPP 319
Cdd:PRK10263 808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHP 848
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
141-302 |
1.71e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 44.86 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 141 PQVPEPEPFETLEPPAKRCRSSeestekgPTGQPQARVQPQTQMTAPKQTQTPdrlPEPPEVQMLPRIQPQALQIQTQpk 220
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQ-------ATAAPTAAVAPPQAPAVPPPPASA---PQQAPAVPLPETTSQLLAARQQ-- 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 221 lLRQAQTQTSPEHLAPQQDQVEPQVPSQPP--WQLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQE 298
Cdd:PRK07994 429 -LQRAQGATKAKKSEPAAASRARPVNSALErlASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHE 507
|
....
gi 1720400483 299 QTSE 302
Cdd:PRK07994 508 KTPE 511
|
|
| Agg_substance |
NF033875 |
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ... |
26-208 |
2.13e-04 |
|
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 45.09 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 26 VTAPSLAAPSLTPPQMVTPNLQQffpqatrqSLLGPPPVGVPINPSQLN-HSGRNTQKQARTPSSTTpnRKDSSSQTVPL 104
Cdd:NF033875 21 VVAPILFLGVLGVVGLATDNVQA--------AELDTQPGTTTVQPDNPDpQSGSETPKTAVSEEATV--QKDTTSQPTKV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 105 EDREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPEPEpfETLEPPAKrcrsseestekgPTGQPQARVQPQTQM 184
Cdd:NF033875 91 EEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSPE--TTNEPLGQ------------PTEVAPAENEANKST 156
|
170 180
....*....|....*....|....
gi 1720400483 185 TAPKQTQTPDRLPEPPEVQMLPRI 208
Cdd:NF033875 157 SIPKEFETPDVDKAVDEAKKDPNI 180
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
133-243 |
2.73e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.69 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 133 GPDSMLSEPQV-PEPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQ 211
Cdd:PRK10263 739 GPHEPLFTPIVePVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ 818
|
90 100 110
....*....|....*....|....*....|..
gi 1720400483 212 ALQIQTQPKllRQAQTQTSPEHLAPQQDQVEP 243
Cdd:PRK10263 819 QPQQPVAPQ--PQYQQPQQPVAPQPQDTLLHP 848
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
38-344 |
2.95e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 38 PPQMVTPNLQqffPQATRQSLLGPPPVGVPINPSqlnhsgrnTQKQARTPSSTTpnrkDSSSQTVPLEDREDPtEGSEEA 117
Cdd:PHA03247 2551 PPPPLPPAAP---PAAPDRSVPPPRPAPRPSEPA--------VTSRARRPDAPP----QSARPRAPVDDRGDP-RGPAPP 2614
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 118 TELQMDTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAK-----RCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQT 192
Cdd:PHA03247 2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS 2694
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 193 PDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPehlAPQQDQVEPQVPS------------QPPWQLQPRETDP 260
Cdd:PHA03247 2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP---ALPAAPAPPAVPAgpatpggparpaRPPTTAGPPAPAP 2771
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 261 PNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTW-PQGSVPPPEQA--SGPACATEPQLSSHA 337
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPTSAqpTAPPPPPGPPPPSLP 2851
|
....*..
gi 1720400483 338 AEAGSDP 344
Cdd:PHA03247 2852 LGGSVAP 2858
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
133-352 |
1.22e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 42.37 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 133 GPDSMLSEPQVP-EPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQP--------------QTQMTAPKQTQTPDRlP 197
Cdd:PTZ00449 513 GPEASGLPPKAPgDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPgpakehkpskiptlSKKPEFPKDPKHPKD-P 591
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 198 EPPEVQMLPRI--------QPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQ 269
Cdd:PTZ00449 592 EEPKKPKRPRSaqrptrpkSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKF 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 270 PQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVP--PPEQASGPACATEPQlsshaaeagSDPDKA 347
Cdd:PTZ00449 672 KEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplPPKLPRDEEFPFEPI---------GDPDAE 742
|
....*
gi 1720400483 348 LPEPV 352
Cdd:PTZ00449 743 QPDDI 747
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
170-261 |
1.57e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.99 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 170 PTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrQAQTQTSPEHLAPQQDQVEPQVP--S 247
Cdd:PRK10263 751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAP----QPQYQQPQQPVAPQPQYQQPQQPvaP 826
|
90
....*....|....
gi 1720400483 248 QPPWQlQPRETDPP 261
Cdd:PRK10263 827 QPQYQ-QPQQPVAP 839
|
|
| ZnF_U1 |
smart00451 |
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ... |
645-678 |
1.74e-03 |
|
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.
Pssm-ID: 197732 [Multi-domain] Cd Length: 35 Bit Score: 36.46 E-value: 1.74e-03
10 20 30
....*....|....*....|....*....|....
gi 1720400483 645 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 678
Cdd:smart00451 3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
29-437 |
1.93e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 29 PSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQarTPSSTTPNRKDSSSQTVPLEDRE 108
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQ--TPTLHPQRLPSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 109 DPTEGSEEATElqmdtcedQDSLVGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTEKGP-------TGQPQARVQPQ 181
Cdd:pfam03154 257 PPSQVSPQPLP--------QPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPpgpspaaPGQSQQRIHTP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 182 TQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQpklLRQAQTQTSPEHL-APQQDQVEPQVPsqPPWQLQPRETDP 260
Cdd:pfam03154 329 PSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQ---LPNPQSHKHPPHLsGPSPFQMNSNLP--PPPALKPLSSLS 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 261 PNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEqtsektqdqpqtwPQGSVPPPEQASGPAcATEPQLSSHAAEA 340
Cdd:pfam03154 404 THHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLP-------------PPAASHPPTSGLHQV-PSQSPFPQHPFVP 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 341 GSDPDKALPE--PVSAQSSEDRSREASAGGLDLGecekragemlGMWGAGSSLKVTILQSSNSRAFNTTPLTSGPRPGDS 418
Cdd:pfam03154 470 GGPPPITPPSgpPTSTSSAMPGIQPPSSASVSSS----------GPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
410 420
....*....|....*....|.
gi 1720400483 419 TSATPAIASTPS--KQSLQFF 437
Cdd:pfam03154 540 PSPEPTVVNTPShaSQSARFY 560
|
|
| GIY-YIG_PLEs |
cd10442 |
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ... |
498-565 |
2.48e-03 |
|
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.
Pssm-ID: 198389 Cd Length: 92 Bit Score: 37.73 E-value: 2.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 498 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 565
Cdd:cd10442 6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
132-258 |
7.50e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 39.68 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 132 VGPDSMLSEPQVPEPepfetlePPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTpdrlPEPPEVQMLPRIQPQ 211
Cdd:PRK10263 772 VAPQPQYQQPQQPVA-------PQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVA----PQPQYQQPQQPVAPQ 840
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1720400483 212 ALQIQTQPKLLRQAQTQ--TSPEHLAPQQDQVEPqvpsqPPWQLQPRET 258
Cdd:PRK10263 841 PQDTLLHPLLMRNGDSRplHKPTTPLPSLDLLTP-----PPSEVEPVDT 884
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
135-325 |
7.56e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 39.68 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 135 DSMLSEPQVPEPEPfetlePPAKRcrSSEESTEKGP-TGQPQARVQPQTQMTAPKQTQTPDRLPEP---PEVQMLPRIQP 210
Cdd:PRK10263 338 EPVTQTPPVASVDV-----PPAQP--TVAWQPVPGPqTGEPVIAPAPEGYPQQSQYAQPAVQYNEPlqqPVQPQQPYYAP 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 211 QALQIQTQPKLLRQAQTQTSPEHLAPQqdqvEPQVPSQPPWQLQPREtdppnqaqaqtqpqPLWQAQSQKQAQtQAHPQv 290
Cdd:PRK10263 411 AAEQPAQQPYYAPAPEQPAQQPYYAPA----PEQPVAGNAWQAEEQQ--------------STFAPQSTYQTE-QTYQQ- 470
|
170 180 190
....*....|....*....|....*....|....*
gi 1720400483 291 PTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGP 325
Cdd:PRK10263 471 PAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPP 505
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
149-321 |
8.71e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 39.63 E-value: 8.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 149 FETLEPPAKrcrsseeSTEKGPTGQPQARVQPQTQMTAPKQTQTPDR-------LPEP-PEVQML----------PRIQP 210
Cdd:pfam09770 102 FNRQQPAAR-------AAQSSAQPPASSLPQYQYASQQSQQPSKPVRtgyekykEPEPiPDLQVDaslwgvapkkAAAPA 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400483 211 QALQIQTQPKLLRQ------------AQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPlwQAQS 278
Cdd:pfam09770 175 PAPQPAAQPASLPApsrkmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQ--QPQQ 252
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1720400483 279 QKQAQTQAHP-QVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQ 321
Cdd:pfam09770 253 PQQHPGQGHPvTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
|
|
| |
