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    sns sticks and stones [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44097, updated on 17-Dec-2024

    Summary

    Official Symbol
    snsprovided by FlyBase
    Official Full Name
    sticks and stonesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024189
    Locus tag
    Dmel_CG33141
    See related
    AllianceGenome:FB:FBgn0024189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    43-49; CG12495; CG13752; CG13753; CG13754; CG13755; CG18464; CG2385; CG33141; CG8278; CT33230; CT33232; Dmel\CG33141; rost; Sns; SnS; SNS; sns20
    Summary
    Enables cell adhesion mediator activity. Involved in several processes, including garland nephrocyte differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nephrocyte diaphragm and plasma membrane. Is active in apical plasma membrane. Is expressed in several structures, including adult head; muscle cell; myoblast; nephrocyte; and sensory organ cell. Used to study kidney disease; nephrotic syndrome; and nephrotic syndrome type 1. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sns in Genome Data Viewer
    Location:
    44F1-44F1; 2-59 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8798489..8856091)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4685994..4743596)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44278 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ryanodine receptor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion mediator activity PubMed 
    enables cell adhesion molecule binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane PubMed 
    is_active_in cell-cell junction  
    located_in nephrocyte diaphragm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    sticks and stones
    Names
    CG33141-PA
    CG33141-PB
    CG33141-PC
    nephrin
    sns-PA
    sns-PB
    sns-PC
    stick-and-stones
    sticks and stone
    sticks-and-stones

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8798489..8856091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043067.2 → NP_001036532.1  sticks and stones, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9F2, Q9V4Y0, Q9V4Y1, Q9V4Y2, Q9V4Y3, Q9V4Y4, Q9V4Y5, Q9V4Y6
      Conserved Domains (6) summary
      cd00096
      Location:885 → 960
      Ig; Immunoglobulin domain
      smart00408
      Location:692 → 757
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:296 → 376
      IG_like; Immunoglobulin like
      cd00063
      Location:967 → 1051
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:678 → 767
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197 → 279
      Ig; Immunoglobulin domain
    2. NM_001299284.1 → NP_001286213.1  sticks and stones, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEH1, Q9V4Y0, Q9V4Y1, Q9V4Y2, Q9V4Y3, Q9V4Y4, Q9V4Y5, Q9V4Y6
      Conserved Domains (6) summary
      cd00096
      Location:885 → 960
      Ig; Immunoglobulin domain
      smart00408
      Location:692 → 757
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:296 → 376
      IG_like; Immunoglobulin like
      cd00063
      Location:967 → 1051
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:678 → 767
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197 → 279
      Ig; Immunoglobulin domain
    3. NM_176106.2 → NP_788286.1  sticks and stones, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7J1, Q9V4Y0, Q9V4Y1, Q9V4Y2, Q9V4Y3, Q9V4Y4, Q9V4Y5, Q9V4Y6
      Related
      FBpp0087716
      Conserved Domains (6) summary
      cd00096
      Location:885 → 960
      Ig; Immunoglobulin domain
      smart00408
      Location:692 → 757
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:296 → 376
      IG_like; Immunoglobulin like
      cd00063
      Location:967 → 1051
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:678 → 767
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197 → 279
      Ig; Immunoglobulin domain
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