Pits Protein interacting with Ttk69 and Sin3A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pitsprovided by FlyBase
Official Full Name: Protein interacting with Ttk69 and Sin3Aprovided by FlyBase
Primary source: FLYBASE:FBgn0030400
Locus tag: Dmel_CG11138
See related: AllianceGenome:FB:FBgn0030400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE48052; BEST:RE18684; CG11138; CG1855; Dmel\CG11138; EP(X)1313; pits; RE18684
Summary: Enables ubiquitin protein ligase activity. Involved in regulation of gene expression. Located in cytoplasm and nuclear periphery. Colocalizes with polytene chromosome. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; presumptive embryonic/larval central nervous system; and synaptic neuropil domain. Used to study central nervous system disease and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14 and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Orthologous to several human genes including IRF2BP1 (interferon regulatory factor 2 binding protein 1) and IRF2BPL (interferon regulatory factor 2 binding protein like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11B1-11B2; 1-39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12569169..12583193, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12463202..12477226, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
Title: Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2024 (e-PCR)
- UniSTS:76846

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein interacting with Ttk69 and Sin3A

Names: CG11138-PC; CG11138-PD; CG11138-PE; Pits-PC; Pits-PD; Pits-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12569169..12583193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272557.1 → NP_001259486.1 protein interacting with Ttk69 and Sin3A, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259486.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAH5, M9PHN7

Conserved Domains (2) summary

pfam00097
Location:503 → 548

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam11261
Location:6 → 57

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
NM_132581.3 → NP_572809.1 protein interacting with Ttk69 and Sin3A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572809.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAH5, Q9VYL7

Related

FBpp0073495

Conserved Domains (2) summary

pfam00097
Location:533 → 578

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam11261
Location:6 → 57

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
NM_001144720.3 → NP_001138192.1 protein interacting with Ttk69 and Sin3A, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138192.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z143, C7LAH5

Conserved Domains (2) summary

pfam00097
Location:548 → 593

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam11261
Location:6 → 57

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger