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    spri sprint [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31987, updated on 9-Dec-2024

    Summary

    Official Symbol
    spriprovided by FlyBase
    Official Full Name
    sprintprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085443
    Locus tag
    Dmel_CG34414
    See related
    AllianceGenome:FB:FBgn0085443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.275; CG12638; CG15297; CG15298; CG15299; CG15300; CG15301; CG32674; CG32680; CG33175; CG34414; Dmel\CG34414; Rin1; Spri
    Old locus tag
    CG32680; CG33175; Dmel_CG32680; Dmel_CG33175
    Summary
    Enables receptor tyrosine kinase binding activity and small GTPase binding activity. Involved in axon extension; positive regulation of border follicle cell migration; and positive regulation of receptor-mediated endocytosis. Located in cell cortex and endocytic vesicle. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; gland; imaginal disc; and nephrocyte. Orthologous to several human genes including RIN2 (Ras and Rab interactor 2) and RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See spri in Genome Data Viewer
    Location:
    9D2-9D3; 1-32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10490069..10585422, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10384102..10479455, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab at 9D Neighboring gene Hybrid male rescue

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables protein kinase binding PubMed 
    enables receptor tyrosine kinase binding PubMed 
    enables small GTPase binding  
    enables small GTPase binding PubMed 
    Component Evidence Code Pubs
    located_in cell cortex PubMed 
    is_active_in cytosol  
    is_active_in endocytic vesicle  
    located_in endocytic vesicle PubMed 

    General protein information

    Preferred Names
    sprint
    Names
    CG34414-PA
    CG34414-PE
    CG34414-PF
    CG34414-PG
    CG34414-PI
    CG34414-PJ
    CG34414-PL
    CG34414-PM
    CG34414-PN
    CG34414-PO
    CG34414-PP
    CG34414-PQ
    CG34414-PR
    spri-PA
    spri-PE
    spri-PF
    spri-PG
    spri-PI
    spri-PJ
    spri-PL
    spri-PM
    spri-PN
    spri-PO
    spri-PP
    spri-PQ
    spri-PR
    sprint-a
    sprint-b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10490069..10585422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272491.1 → NP_001259420.1  sprint, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:415 → 516
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:540 → 620
      UBQ; Ubiquitin-like proteins
    2. NM_001272490.1 → NP_001259419.1  sprint, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:221 → 322
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:346 → 426
      UBQ; Ubiquitin-like proteins
    3. NM_001103474.2 → NP_001096944.1  sprint, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (2) summary
      pfam02204
      Location:499 → 600
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:624 → 704
      UBQ; Ubiquitin-like proteins
    4. NM_001272487.1 → NP_001259416.1  sprint, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain
    5. NM_001272486.1 → NP_001259415.1  sprint, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain
    6. NM_001272492.1 → NP_001259421.1  sprint, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1319 → 1420
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1444 → 1524
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:214 → 311
      SH2; Src homology 2 (SH2) domain
    7. NM_001272488.1 → NP_001259417.1  sprint, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1319 → 1420
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1444 → 1524
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:214 → 311
      SH2; Src homology 2 (SH2) domain
    8. NM_001103471.2 → NP_001096941.2  sprint, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096941.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1227 → 1328
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1352 → 1432
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:122 → 219
      SH2; Src homology 2 (SH2) domain
    9. NM_001272485.1 → NP_001259414.1  sprint, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain
    10. NM_206678.2 → NP_996401.1  sprint, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE83, M9PGU3, M9PH67, M9PHI9, M9PJH2, M9PJH3, Q3KN60, Q8MQV9, Q8MQW8, Q8T4E9, Q9BK48, Q9BK49, Q9W2T4, Q9W2T7, Q9W2U1, T2GGG1
      Conserved Domains (3) summary
      cd01776
      Location:1692 → 1776
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      pfam02204
      Location:1570 → 1668
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:462 → 559
      SH2; Src homology 2 (SH2) domain
    11. NM_001272489.1 → NP_001259418.1  sprint, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1821 → 1922
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1946 → 2026
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:716 → 813
      SH2; Src homology 2 (SH2) domain
    12. NM_001272484.1 → NP_001259413.1  sprint, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain
    13. NM_176723.3 → NP_788896.1  sprint, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQW8
      Related
      FBpp0111601
      Conserved Domains (3) summary
      pfam02204
      Location:1554 → 1655
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:1679 → 1759
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:449 → 546
      SH2; Src homology 2 (SH2) domain
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