Pvr PDGF- and VEGF-receptor related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pvrprovided by FlyBase
Official Full Name: PDGF- and VEGF-receptor relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0032006
Locus tag: Dmel_CG8222
See related: AllianceGenome:FB:FBgn0032006
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 8222; CG8222; CT24332; Dmel\CG8222; DmVEGFR; pvr; PvR; PVR; stai; Vegf; Vegfr; VEGFR; VEGFR-A; Vegfr-b; Vegfr-c; vgr1; Vgr1; VGR1
Summary: Enables transmembrane receptor protein tyrosine kinase activity and vascular endothelial growth factor binding activity. Involved in several processes, including imaginal disc morphogenesis; morphogenesis of an epithelium; and positive regulation of intracellular signal transduction. Acts upstream of with a positive effect on neuron remodeling. Located in plasma membrane. Is expressed in several structures, including adult brain; head; hemocyte; imaginal disc; and somatic precursor cell. Used to study cancer; carcinoma; and nephrolithiasis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); leukemia (multiple); lung disease (multiple); and retinal disease (multiple). Orthologous to several human genes including FLT1 (fms related receptor tyrosine kinase 1) and KDR (kinase insert domain receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 28F4-28F5; 2-30 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8220980..8239878, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8220980..8239878, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites.
Title: Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites.
the PDGFR ortholog Pvr and its ligands mediate paracrine signaling between cortex glia and central brain neuroblasts and their progeny to promote and sustain post-embryonic neurogenesis.
Title: Pvr receptor tyrosine kinase signaling promotes post-embryonic morphogenesis, and survival of glia and neural progenitor cells in Drosophila.
Removal of PVR, although it does not prevent ecdysone-induced fat-body remodeling, causes ecdysone signaling to be up-regulated
Title: Premature remodeling of fat body and fat mobilization triggered by platelet-derived growth factor/VEGF receptor in Drosophila.
Data indicate that the TEAD family transcription factor Scalloped (Scalloped) regulates PDGF/VEGFR receptor (Pvr) expression.
Title: The TEAD family transcription factor Scalloped regulates blood progenitor maintenance and proliferation in Drosophila through PDGF/VEGFR receptor (Pvr) signaling.
the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration.
Title: Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling.
not sufficient predictor of small for gestational age newborn in pregnancies complicated by gestational hypertension/preeclampsia
Title: Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia.
The receptor tyrosine kinase Pvr promotes tissue closure by coordinating corpse removal and epidermal zippering.
Title: The receptor tyrosine kinase Pvr promotes tissue closure by coordinating corpse removal and epidermal zippering.
The products of bip1 and Nucleoporin 98 along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.
Title: Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.
Data indicate that TORC1 activation by PVR involves Tsc1/Tsc2.
Title: Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.
Autocrine platelet-derived growth factor-vascular endothelial growth factor receptor-related (Pvr) pathway activity controls intestinal stem cell proliferation in the adult Drosophila midgut.
Title: Autocrine platelet-derived growth factor-vascular endothelial growth factor receptor-related (Pvr) pathway activity controls intestinal stem cell proliferation in the adult Drosophila midgut.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PDGF- and VEGF-receptor related

Names: CG8222-PA; CG8222-PB; CG8222-PD; CG8222-PE; CG8222-PG; CG8222-PH; CG8222-PI; CG8222-PJ; CG8222-PK; CG8222-PL; CG8222-PM; CG8222-PN; CG8222-PO; PDGF receptor; PDGF- and VEGF receptor related; PDGF- and VEGF- receptor related; PDGF- and VEGF-Receptor related; PDGF- and VEGF-related receptor; PDGF/VEGF receptor; PVF receptor; Pvr-PA; Pvr-PB; Pvr-PD; Pvr-PE; Pvr-PG; Pvr-PH; Pvr-PI; Pvr-PJ; Pvr-PK; Pvr-PL; Pvr-PM; Pvr-PN; Pvr-PO; VEGF receptor; platelet-derived growth factor/vascular endothelial growth factor receptor; stasis; vascular endothelial growth factor receptor; vascular endothelial growth factor receptor-1 like

NP_001162909.1

EC 2.7.10.1

NP_001162910.1

EC 2.7.10.1

NP_001162911.1

EC 2.7.10.1

NP_001188720.1

EC 2.7.10.1

NP_001188721.1

EC 2.7.10.1

NP_001260234.1

EC 2.7.10.1

NP_001260235.1

EC 2.7.10.1

NP_523509.2

EC 2.7.10.1

NP_723365.1

EC 2.7.10.1

NP_787997.2

EC 2.7.10.1

NP_995647.2

EC 2.7.10.1

NP_995648.1

EC 2.7.10.1

NP_995649.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8220980..8239878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169439.2 → NP_001162910.1 PDGF- and VEGF-receptor related, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162910.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHB6, Q95P10

Conserved Domains (7) summary

cd00096
Location:674 → 739

Ig; Immunoglobulin domain

smart00408
Location:779 → 840

IGc2; Immunoglobulin C-2 Type

smart00409
Location:346 → 432

IG; Immunoglobulin

smart00410
Location:672 → 754

IG_like; Immunoglobulin like

pfam07714
Location:935 → 1329

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:466 → 533

Ig; Immunoglobulin domain

cl21453
Location:927 → 1332

PKc_like; Protein Kinases, catalytic domain
NM_001169440.2 → NP_001162911.1 PDGF- and VEGF-receptor related, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162911.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHB7, Q95P10

Conserved Domains (7) summary

cd00096
Location:674 → 739

Ig; Immunoglobulin domain

smart00408
Location:779 → 840

IGc2; Immunoglobulin C-2 Type

smart00409
Location:346 → 432

IG; Immunoglobulin

smart00410
Location:672 → 754

IG_like; Immunoglobulin like

pfam07714
Location:935 → 1329

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:466 → 533

Ig; Immunoglobulin domain

cl21453
Location:927 → 1332

PKc_like; Protein Kinases, catalytic domain
NM_175983.3 → NP_787997.2 PDGF- and VEGF-receptor related, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_787997.2

Status: REVIEWED

UniProtKB/TrEMBL

B6IDV6, Q8T4M0

Conserved Domains (6) summary

cd00096
Location:600 → 665

Ig; Immunoglobulin domain

smart00408
Location:705 → 766

IGc2; Immunoglobulin C-2 Type

smart00409
Location:272 → 358

IG; Immunoglobulin

pfam07714
Location:861 → 1220

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:392 → 459

Ig; Immunoglobulin domain

cl21453
Location:853 → 1223

PKc_like; Protein Kinases, catalytic domain
NM_001273305.1 → NP_001260234.1 PDGF- and VEGF-receptor related, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260234.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCX2, Q95P10

Conserved Domains (7) summary

cd00096
Location:665 → 730

Ig; Immunoglobulin domain

smart00408
Location:770 → 831

IGc2; Immunoglobulin C-2 Type

smart00409
Location:346 → 432

IG; Immunoglobulin

smart00410
Location:663 → 745

IG_like; Immunoglobulin like

pfam07714
Location:926 → 1320

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:466 → 533

Ig; Immunoglobulin domain

cl21453
Location:918 → 1323

PKc_like; Protein Kinases, catalytic domain
NM_205925.3 → NP_995647.2 PDGF- and VEGF-receptor related, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995647.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTI7, Q95P10

Conserved Domains (7) summary

cd00096
Location:596 → 661

Ig; Immunoglobulin domain

smart00408
Location:701 → 762

IGc2; Immunoglobulin C-2 Type

smart00409
Location:277 → 363

IG; Immunoglobulin

smart00410
Location:594 → 676

IG_like; Immunoglobulin like

pfam07714
Location:857 → 1251

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:397 → 464

Ig; Immunoglobulin domain

cl21453
Location:849 → 1254

PKc_like; Protein Kinases, catalytic domain
NM_001201791.2 → NP_001188720.1 PDGF- and VEGF-receptor related, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188720.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRE1, Q95P10

Conserved Domains (7) summary

cd00096
Location:597 → 662

Ig; Immunoglobulin domain

smart00408
Location:702 → 763

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

smart00410
Location:595 → 677

IG_like; Immunoglobulin like

pfam07714
Location:858 → 1252

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:850 → 1255

PKc_like; Protein Kinases, catalytic domain
NM_164801.3 → NP_723365.1 PDGF- and VEGF-receptor related, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723365.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPG1, Q95P10

Related

FBpp0079245

Conserved Domains (7) summary

cd00096
Location:606 → 671

Ig; Immunoglobulin domain

smart00408
Location:711 → 772

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

smart00410
Location:604 → 686

IG_like; Immunoglobulin like

pfam07714
Location:867 → 1261

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:859 → 1264

PKc_like; Protein Kinases, catalytic domain
NM_001273306.1 → NP_001260235.1 PDGF- and VEGF-receptor related, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260235.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCJ1, Q8T9F6

Conserved Domains (6) summary

cd00096
Location:596 → 661

Ig; Immunoglobulin domain

smart00408
Location:701 → 762

IGc2; Immunoglobulin C-2 Type

smart00409
Location:277 → 363

IG; Immunoglobulin

pfam07714
Location:857 → 1251

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:397 → 464

Ig; Immunoglobulin domain

cl21453
Location:849 → 1254

PKc_like; Protein Kinases, catalytic domain
NM_078785.4 → NP_523509.2 PDGF- and VEGF-receptor related, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523509.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9F6, Q9VLQ8

Related

FBpp0079244

Conserved Domains (6) summary

cd00096
Location:606 → 671

Ig; Immunoglobulin domain

smart00408
Location:711 → 772

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

pfam07714
Location:867 → 1261

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:859 → 1264

PKc_like; Protein Kinases, catalytic domain
NM_001169438.2 → NP_001162909.1 PDGF- and VEGF-receptor related, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162909.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHB8, Q8T4M0

Conserved Domains (6) summary

cd00096
Location:606 → 671

Ig; Immunoglobulin domain

smart00408
Location:711 → 772

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

pfam07714
Location:867 → 1226

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:859 → 1229

PKc_like; Protein Kinases, catalytic domain
NM_205927.3 → NP_995649.1 PDGF- and VEGF-receptor related, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995649.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPG1, Q95P10

Conserved Domains (7) summary

cd00096
Location:606 → 671

Ig; Immunoglobulin domain

smart00408
Location:711 → 772

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

smart00410
Location:604 → 686

IG_like; Immunoglobulin like

pfam07714
Location:867 → 1261

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:859 → 1264

PKc_like; Protein Kinases, catalytic domain
NM_205926.3 → NP_995648.1 PDGF- and VEGF-receptor related, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995648.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTI8, Q8T4L8

Conserved Domains (7) summary

cd00096
Location:600 → 665

Ig; Immunoglobulin domain

smart00408
Location:705 → 766

IGc2; Immunoglobulin C-2 Type

smart00409
Location:272 → 358

IG; Immunoglobulin

smart00410
Location:598 → 680

IG_like; Immunoglobulin like

pfam07714
Location:861 → 1255

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:392 → 459

Ig; Immunoglobulin domain

cl21453
Location:853 → 1258

PKc_like; Protein Kinases, catalytic domain
NM_001201792.2 → NP_001188721.1 PDGF- and VEGF-receptor related, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188721.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPG1, Q95P10

Conserved Domains (7) summary

cd00096
Location:606 → 671

Ig; Immunoglobulin domain

smart00408
Location:711 → 772

IGc2; Immunoglobulin C-2 Type

smart00409
Location:278 → 364

IG; Immunoglobulin

smart00410
Location:604 → 686

IG_like; Immunoglobulin like

pfam07714
Location:867 → 1261

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:398 → 465

Ig; Immunoglobulin domain

cl21453
Location:859 → 1264

PKc_like; Protein Kinases, catalytic domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
B6IDV6		B6IDV6
E1JHB6		E1JHB6
E1JHB7		E1JHB7
E1JHB8		E1JHB8
M9MRE1		M9MRE1
M9PCJ1		M9PCJ1
M9PCX2		M9PCX2
Q7KTI7		Q7KTI7
Q7KTI8		Q7KTI8
Q8IPG1		Q8IPG1
Q8T4L8		Q8T4L8
Q8T4L9		Q8T4L9
Q8T4M0		Q8T4M0
Q8T9F6		Q8T9F6
Q95P10		Q95P10
Q9VLQ8		Q9VLQ8