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CG6254 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41244, updated on 9-Dec-2024

Summary

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Official Symbol
CG6254provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037794
Locus tag
Dmel_CG6254
See related
AllianceGenome:FB:FBgn0037794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6254
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6254 in Genome Data Viewer
Location:
85F15-85F15; 3-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10159144..10161331, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5984866..5987053, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene invadolysin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bestrophin 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Tavsanli BC, et al. Genesis, 2001 Nov. PMID 11747204
  2. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Chen LY, et al. Curr Biol, 2006 Jun 20. PMID 16782008
  3. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article
  4. An RNA-interference screen in Drosophila to identify ZAD-containing C2H2 zinc finger genes that function in female germ cells. Shapiro-Kulnane L, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561227, Free PMC Article
  5. Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis. Fingerhut JM, et al. PLoS Genet, 2019 May. PMID 31071079, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6254-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10159144..10161331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141726.3 → NP_649983.2  uncharacterized protein Dmel_CG6254 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649983.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NND3, Q9VH18
    Related
    FBpp0081662
    Conserved Domains (4) summary
    COG5048
    Location:353 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395 → 416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:21 → 99
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:520 → 544
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR10 Q8MR10
Q9VH18 Q9VH18

Gene LinkOut

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