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    Ccdc88a coiled coil domain containing 88A [ Mus musculus (house mouse) ]

    Gene ID: 108686, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ccdc88aprovided by MGI
    Official Full Name
    coiled coil domain containing 88Aprovided by MGI
    Primary source
    MGI:MGI:1925177
    See related
    Ensembl:ENSMUSG00000032740 AllianceGenome:MGI:1925177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ape; Giv; Grdn; Hkrp1; Girdin; A430106J12Rik; C130096N06Rik; C330012F17Rik; D130005J21Rik
    Summary
    Enables microtubule binding activity; protein kinase B binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including TOR signaling; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of neuron projection development. Located in cell leading edge. Is expressed in several structures, including limb; lung; nervous system; sensory organ; and somite. Orthologous to human CCDC88A (coiled-coil domain containing 88A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 8.1), whole brain E14.5 (RPKM 7.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ccdc88a in Genome Data Viewer
    Location:
    11 A3.3; 11 16.61 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29323521..29460808)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29373405..29510808)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23109 Neighboring gene predicted gene 12087 Neighboring gene predicted gene, 51886 Neighboring gene STARR-seq mESC enhancer starr_29023 Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene mitochondrial translational initiation factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G-protein gamma-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP-dissociation inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vascular endothelial growth factor receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor 2 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in TOR signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton-dependent intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of protein location in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of protein location in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in COPI-coated Golgi to ER transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    girdin
    Names
    Akt-phosphorylation enhancer
    Hook-related protein 1
    coiled-coil domain-containing protein 88A
    g alpha-interacting vesicle-associated protein
    girders of actin filament

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363368.2NP_001350297.1  girdin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL935054, BX284634
      UniProtKB/TrEMBL
      A0A6I8MX08
      Related
      ENSMUSP00000159356.2, ENSMUST00000239407.2
      Conserved Domains (1) summary
      cl25732
      Location:4771331
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001363369.2NP_001350298.1  girdin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL935054, BX284634
      Conserved Domains (1) summary
      cl25732
      Location:4771331
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001433417.1NP_001420346.1  girdin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL935054, BX284634
      UniProtKB/Swiss-Prot
      Q5M6X2, Q5M6X4, Q5M6X5, Q5SNZ0, Q5SNZ1, Q8C486, Q8CFU7
    4. NM_176841.5NP_789811.2  girdin isoform 3

      See identical proteins and their annotated locations for NP_789811.2

      Status: VALIDATED

      Source sequence(s)
      AI530462, AK082029, AL935054, BX284634, CD803848, CN458498, CN532842, CO044538
      Consensus CDS
      CCDS24494.1
      UniProtKB/Swiss-Prot
      Q5SNZ0
      Related
      ENSMUSP00000048978.7, ENSMUST00000040182.13
      Conserved Domains (6) summary
      TIGR04523
      Location:4931205
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05622
      Location:18584
      HOOK; HOOK protein
      pfam06156
      Location:10611107
      DUF972; Protein of unknown function (DUF972)
      pfam09455
      Location:488638
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      cl09111
      Location:766859
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl19252
      Location:825943
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29323521..29460808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514455.5XP_006514518.1  girdin isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    2. XM_036156225.1XP_036012118.1  girdin isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22229
      Location:10165
      HkD_Girdin; Hook domain found in Girdin and similar proteins
    3. XM_030245467.2XP_030101327.1  girdin isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    4. XM_036156226.1XP_036012119.1  girdin isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:4771308
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22229
      Location:10165
      HkD_Girdin; Hook domain found in Girdin and similar proteins
    5. XM_017314219.3XP_017169708.1  girdin isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:4771308
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    6. XM_006514452.5XP_006514515.1  girdin isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    7. XM_036156223.1XP_036012116.1  girdin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22229
      Location:10165
      HkD_Girdin; Hook domain found in Girdin and similar proteins
    8. XM_006514451.5XP_006514514.1  girdin isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    9. XM_036156224.1XP_036012117.1  girdin isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22229
      Location:10165
      HkD_Girdin; Hook domain found in Girdin and similar proteins
    10. XM_006514454.5XP_006514517.1  girdin isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:4771331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:18586
      HOOK; HOOK protein
    11. XM_036156227.1XP_036012120.1  girdin isoform X11

      Conserved Domains (3) summary
      COG1196
      Location:4911232
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:182676
      CCDC158; Coiled-coil domain-containing protein 158
      cd22229
      Location:10165
      HkD_Girdin; Hook domain found in Girdin and similar proteins