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    Vang Van Gogh [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35922, updated on 17-Dec-2024

    Summary

    Official Symbol
    Vangprovided by FlyBase
    Official Full Name
    Van Goghprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015838
    Locus tag
    Dmel_CG8075
    See related
    AllianceGenome:FB:FBgn0015838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8075; Dmel\CG8075; stb; Stb; stbm; Stbm; stbm/vang; Strabismus; strabismus/Van Gogh; vang; VANG; vang/stbm; Vang/Stbm; Vangl; vangogh/strabismus
    Summary
    Enables frizzled binding activity. Involved in several processes, including border follicle cell migration; establishment of planar polarity; and positive regulation of cell projection organization. Located in plasma membrane. Is expressed in dorsal-ventral compartment boundary of the wing disc; organism; wing; and wing disc. Used to study neural tube defect. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1) and VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Vang in Genome Data Viewer
    Location:
    45A4-45A6; 2-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9103238..9106796)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4990743..4994301)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4 Neighboring gene Cytosolic thiouridylase subunit 1 Neighboring gene uncharacterized protein Neighboring gene Phosphoglucomutase 2a Neighboring gene Mystery 45A Neighboring gene tsunagi

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables frizzled binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway, planar cell polarity pathway  
    involved_in border follicle cell migration PubMed 
    involved_in dendrite self-avoidance PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation PubMed 
    involved_in establishment of ommatidial planar polarity PubMed 
    involved_in establishment of ommatidial planar polarity PubMed 
    involved_in establishment of planar polarity  
    involved_in establishment of planar polarity PubMed 
    involved_in establishment of planar polarity PubMed 
    involved_in morphogenesis of a polarized epithelium PubMed 
    involved_in ommatidial rotation PubMed 
    involved_in ommatidial rotation PubMed 
    involved_in positive regulation of axon extension PubMed 
    involved_in positive regulation of axon guidance PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Van gogh
    Names
    CG8075-PA
    CG8075-PB
    Van Gogh/Strabismus
    VanGogh
    Vang-PA
    Vang-PB
    Vang-gogh
    sltrabismus
    strabismus
    van gogh
    van-gogh
    vang gogh

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9103238..9106796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057829.4 → NP_477177.1  Van gogh, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7N9, Q8MRA6
      Related
      FBpp0087647
      Conserved Domains (1) summary
      pfam06638
      Location:44 → 581
      Strabismus; Strabismus protein
    2. NM_001273890.2 → NP_001260819.1  Van gogh, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEN4, Q8MRA6
      Conserved Domains (1) summary
      pfam06638
      Location:44 → 581
      Strabismus; Strabismus protein
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