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bdg bedraggled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36747, updated on 9-Dec-2024

Summary

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Official Symbol
bdgprovided by FlyBase
Official Full Name
bedraggledprovided by FlyBase
Primary source
FLYBASE:FBgn0034049
Locus tag
Dmel_CG8291
See related
AllianceGenome:FB:FBgn0034049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8291; Dmel\CG8291
Summary
Predicted to enable neurotransmitter:sodium symporter activity. Involved in R3/R4 cell fate commitment. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; imaginal disc; larval central nervous system; larval ventral nerve cord; and mesectoderm anlage. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See bdg in Genome Data Viewer
Location:
52D2-52D2; 2-76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15923040..15931935, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11810545..11819440, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene slit Neighboring gene antisense RNA:CR46471 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44373 Neighboring gene Death-associated inhibitor of apoptosis 2 Neighboring gene bunker gear Neighboring gene Myelodysplasia/myeloid leukemia factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bedraggled, a putative transporter, influences the tissue polarity complex during the R3/R4 fate decision in the Drosophila eye. Rawls AS, et al. Genetics, 2007 Sep. PMID 17890365, Free PMC Article
  2. The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions. Miller MM, et al. Insect Biochem Mol Biol, 2008 Oct. PMID 18718864, Free PMC Article
  3. Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster. Thimgan MS, et al. J Exp Biol, 2006 Sep. PMID 16916974
  4. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. Huh JR, et al. J Biol Chem, 2007 Jan 19. PMID 17068333
  5. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotransmitter transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neurotransmitter:sodium symporter activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in R3/R4 cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in R3/R4 cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter transport ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in neurotransmitter transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bedraggled
Names
CG8291-PA
CG8291-PB
CG8291-PC
CG8291-PD
bdg-PA
bdg-PB
bdg-PC
bdg-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15923040..15931935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299540.1 → NP_001286469.1  bedraggled, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286469.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSR0
    Conserved Domains (1) summary
    cd06857
    Location:501 → 975
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_137220.3 → NP_611064.2  bedraggled, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611064.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LF97, Q0E961
    UniProtKB/TrEMBL
    Q8MSR0
    Related
    FBpp0086433
    Conserved Domains (1) summary
    cd06857
    Location:501 → 976
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_176181.2 → NP_788361.1  bedraggled, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LF97, Q0E961
    UniProtKB/TrEMBL
    Q8MSR0
    Related
    FBpp0086435
    Conserved Domains (1) summary
    cd06857
    Location:501 → 976
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_166121.2 → NP_725499.2  bedraggled, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725499.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LF97, Q0E961
    UniProtKB/TrEMBL
    Q8MSR0
    Related
    FBpp0086434, FBtr0087299
    Conserved Domains (1) summary
    cd06857
    Location:501 → 976
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E961.1 Q0E961
Q8MSR0 Q8MSR0

Gene LinkOut

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