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fw furrowed [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32162, updated on 4-Jan-2025

Summary

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Official Symbol
fwprovided by FlyBase
Official Full Name
furrowedprovided by FlyBase
Primary source
FLYBASE:FBgn0001083
Locus tag
Dmel_CG1500
See related
AllianceGenome:FB:FBgn0001083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1500; CT3745; Dmel\CG1500; Fw; fw-like; wr
Summary
Predicted to enable carbohydrate binding activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; imaginal disc-derived wing hair organization; and protein stabilization. Located in apical junction complex. Is expressed in adult head; embryonic/larval proventriculus; eye; and larval brain. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to several human genes including SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
11A1-11A1; 1-38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11992915..12003914, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11886948..11897947, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene twisted gastrulation Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene regucalcin Neighboring gene Chromatin accessibility complex 16kD protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of selectins in Drosophila eye and bristle development. Leshko-Lindsay LA, et al. Development, 1997 Jan. PMID 9006078
  2. Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo. Cant K, et al. Genetics, 1996 May. PMID 8722779, Free PMC Article
  3. Genetic instability in Drosophila melanogaster: Mutable miniature (mu). Green MM. Mutat Res, 1975 Jul. PMID 807842
  4. The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization. Chin ML, et al. Dev Cell, 2013 Sep 16. PMID 23973164, Free PMC Article
  5. Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. Adrion JR, et al. Mol Biol Evol, 2014 Dec. PMID 25158796, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
furrowed
Names
CG1500-PA
CG1500-PB
CG1500-PC
fw-PA
fw-PB
fw-PC
wrinkled

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11992915..12003914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078581.3 → NP_511136.2  furrowed, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511136.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYR4
    Related
    FBpp0073424
    Conserved Domains (5) summary
    smart00607
    Location:113 → 261
    FTP; eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
    cd00033
    Location:525 → 579
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00037
    Location:281 → 403
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PHA02927
    Location:637 → 897
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:841 → 896
    Sushi; Sushi repeat (SCR repeat)

  2. NM_001298217.1 → NP_001285146.1  furrowed, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285146.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYR4
    Conserved Domains (5) summary
    smart00607
    Location:113 → 261
    FTP; eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
    cd00033
    Location:525 → 579
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00037
    Location:281 → 403
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PHA02927
    Location:637 → 897
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:841 → 896
    Sushi; Sushi repeat (SCR repeat)

  3. NM_001103491.1 → NP_001096961.1  furrowed, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUT1
    Conserved Domains (3) summary
    cd00033
    Location:106 → 160
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:218 → 478
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:422 → 477
    Sushi; Sushi repeat (SCR repeat)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUT1 A8JUT1
P91658 P91658
Q9VYR4 Q9VYR4

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