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    Pi3K68D Phosphatidylinositol 3-kinase 68D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39329, updated on 17-Dec-2024

    Summary

    Official Symbol
    Pi3K68Dprovided by FlyBase
    Official Full Name
    Phosphatidylinositol 3-kinase 68Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015278
    Locus tag
    Dmel_CG11621
    See related
    AllianceGenome:FB:FBgn0015278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    11621; BcDNA:LD15217; CG11621; cpk; Cpk; Dmel\CG11621; dPI3k; dPI3K; dPIK; PI(3)K; Pi3K; PI3K; PI3K 68D; PI3K 68_D; PI3K-68D; PI3K-68D/E; pi3k68d; PI3K68D; PI3K_68D; PI[[3]]K
    Summary
    Enables several functions, including SH3 domain binding activity; phosphatidylinositol kinase activity; and small GTPase binding activity. Involved in cortical actin cytoskeleton organization; negative regulation of epidermal growth factor receptor signaling pathway; and phosphatidylinositol phosphate biosynthetic process. Located in endosome membrane. Is expressed in several structures, including adult brain; adult head; adult pars intercerebralis; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) and PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pi3K68D in Genome Data Viewer
    Location:
    68D4-68D6; 3-36 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11774650..11790013, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11767750..11783113, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mir-956 stem loop Neighboring gene Tim13 Neighboring gene uncharacterized protein Neighboring gene twitchy Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in endosome membrane PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase 68D
    Names
    CG11621-PA
    CG11621-PB
    CG11621-PC
    CG11621-PD
    CG11621-PE
    PI 3-kinase
    PI3-kinase
    Pi3K68D-PA
    Pi3K68D-PB
    Pi3K68D-PC
    Pi3K68D-PD
    Pi3K68D-PE
    dPI 3-kinase
    phosphotidylinositol 3 kinase 68D
    NP_001163420.1
    NP_001261724.1
    NP_524028.2
    NP_729743.1
    NP_729745.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11774650..11790013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169949.2 → NP_001163420.1  phosphatidylinositol 3-kinase 68D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNX6, Q7K3H0
      Conserved Domains (7) summary
      cd06884
      Location:1611 → 1721
      PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
      cd04012
      Location:844 → 1021
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1751 → 1871
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:561 → 669
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00869
      Location:1038 → 1202
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05166
      Location:1235 → 1583
      PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
      cl04813
      Location:58 → 392
      EIN3; Ethylene insensitive 3
    2. NM_168475.3 → NP_729743.1  phosphatidylinositol 3-kinase 68D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNX6, Q7K3H0
      Related
      FBpp0075818
      Conserved Domains (7) summary
      cd06884
      Location:1611 → 1721
      PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
      cd04012
      Location:844 → 1021
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1751 → 1871
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:561 → 669
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00869
      Location:1038 → 1202
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05166
      Location:1235 → 1583
      PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
      cl04813
      Location:58 → 392
      EIN3; Ethylene insensitive 3
    3. NM_079304.4 → NP_524028.2  phosphatidylinositol 3-kinase 68D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524028.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNX6, Q7K3H0
      Related
      FBpp0075819
      Conserved Domains (7) summary
      cd06884
      Location:1611 → 1721
      PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
      cd04012
      Location:844 → 1021
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1751 → 1871
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:561 → 669
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00869
      Location:1038 → 1202
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05166
      Location:1235 → 1583
      PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
      cl04813
      Location:58 → 392
      EIN3; Ethylene insensitive 3
    4. NM_168476.3 → NP_729745.1  phosphatidylinositol 3-kinase 68D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RR5
      Related
      FBpp0075817
      Conserved Domains (1) summary
      cl04813
      Location:58 → 327
      EIN3; Ethylene insensitive 3
    5. NM_001274795.1 → NP_001261724.1  phosphatidylinositol 3-kinase 68D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RR5
      Conserved Domains (1) summary
      cl04813
      Location:58 → 327
      EIN3; Ethylene insensitive 3
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