U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    clu clueless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36793, updated on 9-Dec-2024

    Summary

    Official Symbol
    cluprovided by FlyBase
    Official Full Name
    cluelessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034087
    Locus tag
    Dmel_CG8443
    See related
    AllianceGenome:FB:FBgn0034087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.143; CG8443; Clu; Dmel\CG8443
    Summary
    Enables mRNA binding activity and ribosome binding activity. Involved in asymmetric neuroblast division and mitochondrion localization. Located in several cellular components, including Golgi apparatus; mitochondrion; and mitotic spindle. Is extrinsic component of mitochondrial outer membrane. Part of outer mitochondrial membrane protein complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; larval muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See clu in Genome Data Viewer
    Location:
    52F5-52F7; 2-78 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16186584..16194277)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12074089..12081782)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lissencephaly-1 Neighboring gene uncharacterized protein Neighboring gene calypso Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: 16193899-16193962 mobile_element_type = transposon:INE-1{}6176

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables ribosome binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol PubMed 

    General protein information

    Preferred Names
    clueless
    Names
    CG8443-PA
    CG8443-PB
    clu-PA
    clu-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16186584..16194277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137251.3 → NP_611095.1  clueless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAB5, Q6NNE5
      Related
      FBpp0086380
      Conserved Domains (7) summary
      sd00006
      Location:1190 → 1215
      TPR; TPR repeat [structural motif]
      pfam05303
      Location:324 → 387
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:872 → 1073
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:445 → 665
      CLU; Clustered mitochondria
      pfam13374
      Location:1146 → 1184
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1225 → 1303
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:159 → 232
      CLU_N; Mitochondrial function, CLU-N-term
    2. NM_001274092.1 → NP_001261021.1  clueless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261021.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEX0
      Conserved Domains (7) summary
      sd00006
      Location:1031 → 1056
      TPR; TPR repeat [structural motif]
      pfam05303
      Location:165 → 228
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:713 → 914
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:286 → 506
      CLU; Clustered mitochondria
      pfam13374
      Location:987 → 1025
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1066 → 1144
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:2 → 73
      CLU_N; Mitochondrial function, CLU-N-term
    External link. Please review our privacy policy.