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baz bazooka [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32703, updated on 9-Dec-2024

Summary

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Official Symbol
bazprovided by FlyBase
Official Full Name
bazookaprovided by FlyBase
Primary source
FLYBASE:FBgn0000163
Locus tag
Dmel_CG5055
See related
AllianceGenome:FB:FBgn0000163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Baz; BAZ; Baz/Par-3; Baz/Par3; Bazooka; CG5055; D-par3; D-Par3; Dmel\CG5055; dPar-3; l(1)G0484; par-3; Par-3; PAR-3; par3; Par3; PAR3
Summary
Enables phosphatidic acid binding activity and phosphatidylinositol binding activity. Involved in several processes, including cell junction assembly; generation of neurons; and oogenesis. Located in cytoplasmic side of apical plasma membrane; spot adherens junction; and zonula adherens. Part of PAR polarity complex. Is expressed in several structures, including Malpighian tubule Type II cell; NMJ bouton; chordotonal neurons; germline cell; and somatic cell of ovariole. Used to study developmental disorder of mental health. Orthologous to several human genes including PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See baz in Genome Data Viewer
Location:
15F1-15F2; 1-57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17160006..17200728)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17054039..17094738)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene xmas Neighboring gene long non-coding RNA:CR44026 Neighboring gene Tubulin tyrosine ligase-like 1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved oligomerization domain in drosophila Bazooka/PAR-3 is important for apical localization and epithelial polarity. Benton R, et al. Curr Biol, 2003 Aug 5. PMID 12906794
  2. Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial development. Yu CG, et al. Mol Biol Cell, 2012 Sep. PMID 22833561, Free PMC Article
  3. Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3). Yu CG, et al. PLoS One, 2014. PMID 24466078, Free PMC Article
  4. Dynamics of PAR Proteins Explain the Oscillation and Ratcheting Mechanisms in Dorsal Closure. Durney CH, et al. Biophys J, 2018 Dec 4. PMID 30446158, Free PMC Article
  5. Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation. Razzell W, et al. Development, 2014 May. PMID 24718989, Free PMC Article

See all (645) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.
    Title: A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.
  2. Par3/bazooka binds NICD and promotes notch signaling during Drosophila development.
    Title: Par3/bazooka binds NICD and promotes notch signaling during Drosophila development.
  3. A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
    Title: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
  4. Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.
    Title: Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.
  5. Par-3 family proteins in cell polarity & adhesion.
    Title: Par-3 family proteins in cell polarity & adhesion.
  6. Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
    Title: Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
  7. A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity.
    Title: A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity.
  8. These results point to a connection between membrane trafficking and dynein-mediated transport to sustain PAR3 asymmetry.
    Title: Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution.
  9. The results indicated that elevated Par3 expression induces cortical localization of the Par-complex at the interphase.
    Title: Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization.
  10. The authors show that during Drosophila dorsal closure fusing cell interfaces are remodelled from en-face contacts at fusion to an interlocking arrangement after fusion, and demonstrate that changes in interface length and geometry are dependent on the spatiotemporal regulation of cytoskeletal tension and Bazooka/Par3.
    Title: Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 17167449-17167542 mobile_element_type = transposon:INE-1{}4211

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adherens junction organization HGI PubMed 
involved_in apical protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axis elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in border follicle cell delamination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in branching involved in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-band extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zonula adherens assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PAR polarity complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spot adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in zonula adherens IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bazooka
Names
Baz
Bazooka-Par3
Bazooka/Par-3
Bazooka/Par3
CG5055-PA
CG5055-PB
CG5055-PC
CG5055-PD
baz-PA
baz-PB
baz-PC
baz-PD
par-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17160006..17200728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347807.1 → NP_001334669.1  bazooka, isoform A [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96782, Q9VX75

  2. NM_001042818.4 → NP_001036283.1  bazooka, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96782, Q0KHR3
    Conserved Domains (3) summary
    cd00992
    Location:462 → 548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:62 → 174
    DUF3534; Domain of unknown function (DUF3534)
    cl00663
    Location:390 → 436
    CRS1_YhbY; CRS1 / YhbY (CRM) domain

  3. NM_001298436.2 → NP_001285365.1  bazooka, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96782, X2JCB3
    Conserved Domains (3) summary
    cd00992
    Location:462 → 548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:62 → 174
    DUF3534; Domain of unknown function (DUF3534)
    cl00663
    Location:390 → 436
    CRS1_YhbY; CRS1 / YhbY (CRM) domain

  4. NM_001298435.2 → NP_001285364.1  bazooka, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96782, X2JFU8
    Conserved Domains (3) summary
    cd00992
    Location:441 → 527
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1 → 153
    DUF3534; Domain of unknown function (DUF3534)
    cl00663
    Location:369 → 415
    CRS1_YhbY; CRS1 / YhbY (CRM) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96782 O96782
Q0KHR3 Q0KHR3
Q86NX9 Q86NX9
Q9VX75 Q9VX75
X2JCB3 X2JCB3
X2JFU8 X2JFU8

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