U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mdh2 Malate dehydrogenase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42185, updated on 17-Dec-2024

    Summary

    Official Symbol
    Mdh2provided by FlyBase
    Official Full Name
    Malate dehydrogenase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0262559
    Locus tag
    Dmel_CG7998
    See related
    AllianceGenome:FB:FBgn0262559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 7998; CG7998; Dmel\CG7998; l(3)psg7; Mdh; MDH-2; mdh2; MDH2; mMdh; psg7
    Summary
    Enables L-malate dehydrogenase (NAD+) activity. Involved in several processes, including autophagic cell death; instar larval or pupal development; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; adult heart; and germline cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mdh2 in Genome Data Viewer
    Location:
    90F8-90F9; 3-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18226396..18228718)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14052118..14054440)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription termination factor 5 Neighboring gene Novel nucleolar protein 3 Neighboring gene uncharacterized protein Neighboring gene reversed polarity Neighboring gene uncharacterized protein Neighboring gene 14-3-3epsilon

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in NADH metabolic process PubMed 
    involved_in autophagic cell death PubMed 
    involved_in carboxylic acid metabolic process  
    involved_in gluconeogenesis  
    involved_in larval midgut cell programmed cell death PubMed 
    involved_in malate metabolic process PubMed 
    involved_in malate-aspartate shuttle  
    involved_in oxaloacetate metabolic process PubMed 
    involved_in positive regulation of programmed cell death PubMed 
    involved_in pupal development PubMed 
    involved_in regulation of programmed cell death PubMed 
    involved_in salivary gland histolysis PubMed 
    involved_in tricarboxylic acid cycle  
    involved_in tricarboxylic acid cycle PubMed 
    involved_in tricarboxylic acid cycle  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    malate dehydrogenase 2
    Names
    CG7998-PA
    L-Malate dehydrogenase
    Mdh2-PA
    lethal (3) persistent salivary gland 7
    malate dehydrogenase
    malate dehydrogenase (mitochondrial)
    malic DH
    mitochondrial malate dehydrogenase
    mitochondrial-Mdh
    NP_650696.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18226396..18228718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142439.3 → NP_650696.1  malate dehydrogenase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEB1
      Related
      FBpp0082985
      Conserved Domains (1) summary
      cd01337
      Location:25 → 334
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
    External link. Please review our privacy policy.