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CG10863 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38463, updated on 4-Jan-2025

Summary

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Official Symbol
CG10863provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0027552
Locus tag
Dmel_CG10863
See related
AllianceGenome:FB:FBgn0027552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH10614; dm1/AKR2E3; Dmel\CG10863
Summary
Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in cytosol. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG10863 in Genome Data Viewer
Location:
64A1-64A1; 3-10 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3941008..3942465, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3941008..3942465, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43916 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Duque P, et al. Genes (Basel), 2022 Oct 21. PMID 36292802, Free PMC Article
  2. Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Di Luccio E, et al. Biochem J, 2006 Nov 15. PMID 16813561, Free PMC Article
  3. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
  4. Drosophila ventral furrow morphogenesis: a proteomic analysis. Gong L, et al. Development, 2004 Feb. PMID 14711877
  5. Proteomic characterization of inbreeding-related cold sensitivity in Drosophila melanogaster. Vermeulen CJ, et al. PLoS One, 2013. PMID 23658762, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10863-PA
NP_647840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3941008..3942465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139583.4 → NP_647840.1  uncharacterized protein Dmel_CG10863 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3L7, Q9Y112
    Related
    FBpp0073028
    Conserved Domains (2) summary
    COG0656
    Location:6 → 304
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 290
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y112 Q9Y112

Gene LinkOut

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