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    Eaf ELL-associated factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35660, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eafprovided by FlyBase
    Official Full Name
    ELL-associated factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033166
    Locus tag
    Dmel_CG11166
    See related
    AllianceGenome:FB:FBgn0033166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11166; CG1706; dEaf; Dmel\CG11166; EP(2)2475; LD35207
    Summary
    Predicted to enable transcription elongation factor activity. Involved in cellular response to heat and positive regulation of DNA-templated transcription. Located in nucleoplasm. Part of super elongation complex. Is expressed in adult brain cell body rind and organism. Orthologous to human EAF1 (ELL associated factor 1) and EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Eaf in Genome Data Viewer
    Location:
    43B2-43B2; 2-56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7396850..7407819, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3284355..3295324, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 15 Neighboring gene antisense RNA:CR44201 Neighboring gene Gustatory receptor 43a Neighboring gene Glyoxalase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4977 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44202 Neighboring gene sine oculis

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables transcription elongation factor activity  
    Component Evidence Code Pubs
    located_in nucleoplasm PubMed 
    located_in nucleoplasm  
    part_of super elongation complex  
    part_of super elongation complex PubMed 
    part_of transcription elongation factor complex  
    part_of transcription elongation factor complex PubMed 

    General protein information

    Preferred Names
    ELL-associated factor
    Names
    CG11166-PA
    CG11166-PB
    CG11166-PC
    CG11166-PD
    Eaf-PA
    Eaf-PB
    Eaf-PC
    Eaf-PD
    dELL-associated factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7396850..7407819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136429.4 → NP_610273.1  ELL-associated factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088079
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor
    2. NM_165521.3 → NP_724550.1  ELL-associated factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JRJ1
      Related
      FBpp0088081
      Conserved Domains (1) summary
      pfam09816
      Location:8 → 68
      EAF; RNA polymerase II transcription elongation factor
    3. NM_165518.3 → NP_724547.1  ELL-associated factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088080
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor
    4. NM_165519.3 → NP_724548.1  ELL-associated factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGZ1, Q7JRJ1, Q86PA3
      Related
      FBpp0088078
      Conserved Domains (1) summary
      pfam09816
      Location:22 → 122
      EAF; RNA polymerase II transcription elongation factor
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