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gnu giant nuclei [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39615, updated on 9-Dec-2024

Summary

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Official Symbol
gnuprovided by FlyBase
Official Full Name
giant nucleiprovided by FlyBase
Primary source
FLYBASE:FBgn0001120
Locus tag
Dmel_CG5272
See related
AllianceGenome:FB:FBgn0001120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5272; Dmel\CG5272; Gnu; GNU
Summary
Enables protein kinase activator activity. Involved in several processes, including egg activation; mitotic cell cycle; and negative regulation of DNA replication. Part of protein kinase complex. Is expressed in oocyte and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See gnu in Genome Data Viewer
Location:
70F6-70F6; 3-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14802380..14803360, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14795480..14796460, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Helicase with zinc finger Neighboring gene NHP2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44702

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Hidden polyteny in giant embryonic nuclei of Drosophila melanogaster gnu mutants]. Mal'tseva NI, et al. Genetika, 1991 May. PMID 1916260
  2. The positioning mechanics of microtubule asters in Drosophila embryo explants. de-Carvalho J, et al. Elife, 2024 Mar 1. PMID 38426416, Free PMC Article
  3. The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila. Freeman M, et al. Cell, 1986 Aug 1. PMID 3089628
  4. Spatial and temporal control of mitotic cyclins by the Gnu regulator of embryonic mitosis in Drosophila. Zhang XH, et al. J Cell Sci, 2004 Jul 15. PMID 15226379
  5. The gnu mutation of Drosophila causes inappropriate DNA synthesis in unfertilized and fertilized eggs. Freeman M, et al. Genes Dev, 1987 Nov. PMID 12465624

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG kinase activity.
    Title: Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.
  2. component of novel protein kinase complex that specifically regulates S-M cell cycles
    Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
  3. identification of the gnu gene encoding a novel phosphoprotein dephosphorylated by protein phosphatase 1 at egg activation; Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses
    Title: giant nuclei is essential in the cell cycle transition from meiosis to mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in egg activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
giant nuclei
Names
CG5272-PA
gnu-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14802380..14803360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140469.3 → NP_648726.1  giant nuclei [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AP16, C0MJG7, Q9VUI0
    Related
    FBpp0075447
    Conserved Domains (1) summary
    pfam07647
    Location:174 → 237
    SAM_2; SAM domain (Sterile alpha motif)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUI0 Q9VUI0

Gene LinkOut

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