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    par-6 par-6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32752, updated on 9-Dec-2024

    Summary

    Official Symbol
    par-6provided by FlyBase
    Official Full Name
    par-6provided by FlyBase
    Primary source
    FLYBASE:FBgn0026192
    Locus tag
    Dmel_CG5884
    See related
    AllianceGenome:FB:FBgn0026192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5884; Dm-Par-6; Dm-Par6; Dmel\CG5884; dmPar-6; DmPar-6; DmPAR-6; Dmpar6; DmPar6; dPar-6; dPAR-6; DPar-6; DPar6; par; Par; Par-6; PAR-6; par6; Par6; PAR6
    Summary
    Enables protein kinase inhibitor activity. Involved in several processes, including border follicle cell migration; nervous system development; and positive regulation of plasma membrane bounded cell projection assembly. Located in several cellular components, including apical cortex; apical plasma membrane; and muscle cell postsynaptic specialization. Part of PAR polarity complex. Is expressed in several structures, including NMJ bouton; adult head; embryonic hindgut; epithelium; and tracheocyte. Orthologous to several human genes including PARD6B (par-6 family cell polarity regulator beta) and PARD6G (par-6 family cell polarity regulator gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See par-6 in Genome Data Viewer
    Location:
    16C1-16C1; 1-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17703352..17707096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17597385..17601129)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene chascon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene raskol

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apical protein localization PubMed 
    involved_in asymmetric neuroblast division PubMed 
    involved_in border follicle cell migration PubMed 
    involved_in branching involved in open tracheal system development PubMed 
    involved_in centrosome cycle  
    involved_in establishment of neuroblast polarity PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity PubMed 
    involved_in establishment or maintenance of neuroblast polarity PubMed 
    involved_in establishment or maintenance of polarity of embryonic epithelium PubMed 
    involved_in morphogenesis of a polarized epithelium PubMed 
    involved_in positive regulation of filopodium assembly PubMed 
    involved_in positive regulation of lamellipodium assembly PubMed 
    involved_in positive regulation of smoothened signaling pathway PubMed 
    involved_in synapse assembly PubMed 
    involved_in terminal branching, open tracheal system PubMed 
    involved_in zonula adherens assembly PubMed 
    Component Evidence Code Pubs
    part_of PAR polarity complex PubMed 
    located_in apical cortex PubMed 
    located_in apical cortex PubMed 
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane PubMed 
    located_in cell cortex PubMed 
    located_in muscle cell postsynaptic specialization PubMed 
    located_in plasma membrane PubMed 
    part_of subapical complex PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    par-6
    Names
    CG5884-PA
    CG5884-PB
    Par-6
    Par6
    par-6-PA
    par-6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17703352..17707096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133010.5 → NP_573238.1  par-6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97111
      Related
      FBpp0074229
      Conserved Domains (2) summary
      cd06403
      Location:20 → 101
      PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
      cd00992
      Location:159 → 250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_167575.2 → NP_728094.1  par-6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97111
      Related
      FBpp0074230
      Conserved Domains (2) summary
      cd06403
      Location:20 → 101
      PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
      cd00992
      Location:159 → 250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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