U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GCC88 GRIP and coiled-coil domain containing 88 kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41350, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
GCC88provided by FlyBase
Official Full Name
GRIP and coiled-coil domain containing 88 kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0037881
Locus tag
Dmel_CG10703
See related
AllianceGenome:FB:FBgn0037881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10703; dGCC88; Dmel\CG10703
Summary
Enables small GTPase binding activity. Predicted to be involved in Golgi vesicle transport. Located in Golgi trans cisterna. Is expressed in adult head. Orthologous to human GCC1 (GRIP and coiled-coil domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GCC88 in Genome Data Viewer
Location:
86D8-86D8; 3-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11228158..11230600, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7053880..7056322, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L3 Neighboring gene SCP-containing protein C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diphthamide biosynthesis 3 Neighboring gene Arfaptin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. bicoid RNA localization requires the trans-Golgi network. Cai X, et al. Hereditas, 2019. PMID 31528161, Free PMC Article
  2. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
  3. Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Gardiol A, et al. Dev Biol, 2014 Aug 15. PMID 24951879, Free PMC Article
  4. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
  5. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. Christis C, et al. J Cell Biol, 2012 Feb 6. PMID 22291037, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
GRIP and coiled-coil domain containing 88 kDa
Names
CG10703-PA
GCC88 ortholog
GCC88-PA
dGCC88

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11228158..11230600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141798.3 → NP_650055.1  GRIP and coiled-coil domain containing 88 kDa [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGR1
    Related
    FBpp0081842
    Conserved Domains (1) summary
    pfam01465
    Location:646 → 688
    GRIP; GRIP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGR1 Q9VGR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous