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    Glys Glycogen synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41823, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glysprovided by FlyBase
    Official Full Name
    Glycogen synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266064
    Locus tag
    Dmel_CG6904
    See related
    AllianceGenome:FB:FBgn0266064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.108; CG6904; CG6940; dGS; Dmel\CG6904; GlyS; GS; Gys
    Summary
    Enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in cellular response to starvation; cellular response to sucrose stimulus; and glycogen biosynthetic process. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; larval muscle cell; mesoderm; and visceral mesoderm derivative. Used to study Lafora disease. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Glys in Genome Data Viewer
    Location:
    88E2-88E2; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15141843..15147531, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10967565..10973253, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol PubMed 

    General protein information

    Preferred Names
    glycogen synthase
    Names
    CG6904-PA
    CG6904-PB
    CG6904-PC
    CG6904-PD
    Glys-PA
    Glys-PB
    Glys-PC
    Glys-PD
    NP_001262583.1
    NP_650422.1
    NP_731967.2
    NP_731968.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15141843..15147531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169611.2 → NP_731968.1  glycogen synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Related
      FBpp0082494
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase
    2. NM_142165.3 → NP_650422.1  glycogen synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Related
      FBpp0082495
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase
    3. NM_001275654.1 → NP_001262583.1  glycogen synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase
    4. NM_169610.2 → NP_731967.2  glycogen synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731967.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2X5, Q9VFC8
      UniProtKB/TrEMBL
      D5SHR2
      Related
      FBpp0082496
      Conserved Domains (1) summary
      pfam05693
      Location:53 → 697
      Glycogen_syn; Glycogen synthase
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