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Myo10A Myosin 10A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32028, updated on 4-Jan-2025

Summary

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Official Symbol
Myo10Aprovided by FlyBase
Official Full Name
Myosin 10Aprovided by FlyBase
Primary source
FLYBASE:FBgn0263705
Locus tag
Dmel_CG43657
See related
AllianceGenome:FB:FBgn0263705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
10A; AAF47980; CG16922; CG2136; CG2174; CG43657; Dmel\CG43657; DmXV; myo10A; Myo20; Syph
Old locus tag
Dmel_CG16922; Dmel_CG2174
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in dorsal closure; filopodium assembly; and intracellular protein transport. Located in filopodium and neuronal cell body. Is expressed in adult brain cell body rind; adult head; lamina; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Myo10A in Genome Data Viewer
Location:
9F12-9F13; 1-33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10930840..10964046)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10824873..10858079)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene vermilion Neighboring gene Rab at 9Fa Neighboring gene Rab at 9Fb Neighboring gene C901 Neighboring gene vexed Neighboring gene SET and MYND domain containing, arthropod-specific, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition. Clements R, et al. Dev Biol, 2024 Jan. PMID 37956923, Free PMC Article
  2. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Segal D, et al. Dev Cell, 2016 Aug 8. PMID 27505416
  3. Molecular to organismal chirality is induced by the conserved myosin 1D. Lebreton G, et al. Science, 2018 Nov 23. PMID 30467170, Free PMC Article
  4. How to make a curved Drosophila bristle using straight actin bundles. Tilney LG, et al. Proc Natl Acad Sci U S A, 2005 Dec 27. PMID 16357198, Free PMC Article
  5. Rapidly evolving Rab GTPase paralogs and reproductive isolation in Drosophila. Hutter P. Adv Genet, 2007. PMID 17452244

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.
    Title: Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.
  2. suggest a mechanism for Sisyphus (the Drosophila myosin XV homolog) in which it maintains a balance between actin and microtubule cytoskeleton components
    Title: Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: 10939862-10939928 mobile_element_type = transposon:INE-1{}5845

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin 10A
Names
CG43657-PC
CG43657-PD
CG43657-PE
CG43657-PF
Myo10A-PC
Myo10A-PD
Myo10A-PE
Myo10A-PF
myosin XV
sisyphus
unconventional myosin class XV
NP_001036269.2
NP_001259435.1
NP_001285103.1
NP_572669.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10930840..10964046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298174.1 → NP_001285103.1  myosin 10A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285103.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZ45
    Conserved Domains (7) summary
    smart00242
    Location:65 → 745
    MYSc; Myosin. Large ATPases
    smart00295
    Location:2732 → 2942
    B41; Band 4.1 homologues
    cd13201
    Location:2938 → 3047
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:2829 → 2934
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:78 → 737
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    pfam00784
    Location:2613 → 2719
    MyTH4; MyTH4 domain
    cl02480
    Location:923 → 1080
    MyTH4; MyTH4 domain

  2. NM_001042804.3 → NP_001036269.2  myosin 10A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036269.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHU0
    Conserved Domains (7) summary
    smart00242
    Location:156 → 836
    MYSc; Myosin. Large ATPases
    smart00295
    Location:2823 → 3033
    B41; Band 4.1 homologues
    cd13201
    Location:3029 → 3138
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:2920 → 3025
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:169 → 828
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    pfam00784
    Location:2704 → 2810
    MyTH4; MyTH4 domain
    cl02480
    Location:1014 → 1171
    MyTH4; MyTH4 domain

  3. NM_132441.3 → NP_572669.2  myosin 10A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572669.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZ45
    Conserved Domains (7) summary
    smart00242
    Location:65 → 745
    MYSc; Myosin. Large ATPases
    smart00295
    Location:2732 → 2942
    B41; Band 4.1 homologues
    cd13201
    Location:2938 → 3047
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:2829 → 2934
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:78 → 737
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    pfam00784
    Location:2613 → 2719
    MyTH4; MyTH4 domain
    cl02480
    Location:923 → 1080
    MyTH4; MyTH4 domain

  4. NM_001272506.1 → NP_001259435.1  myosin 10A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGV5
    Conserved Domains (4) summary
    smart00295
    Location:747 → 957
    B41; Band 4.1 homologues
    cd13201
    Location:953 → 1062
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:844 → 949
    FERM_B-lobe; FERM domain B-lobe
    pfam00784
    Location:628 → 734
    MyTH4; MyTH4 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGV5 M9PGV5
Q0KHU0 Q0KHU0
Q8T6M1 Q8T6M1
Q9VZ45 Q9VZ45

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