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    Pms2 Pms2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36705, updated on 17-Dec-2024

    Summary

    Official Symbol
    Pms2provided by FlyBase
    Official Full Name
    Pms2provided by FlyBase
    Primary source
    FLYBASE:FBgn0011660
    Locus tag
    Dmel_CG8169
    See related
    AllianceGenome:FB:FBgn0011660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8169; Dmel\CG8169; dmlh-2; dmlh2; dpms2; Mlh2; pms2; PMS2
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to several human genes including PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pms2 in Genome Data Viewer
    Location:
    51F11-51F11; 2-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15368074..15371520, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11255579..11259025, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44371 Neighboring gene Hormone receptor 51 Neighboring gene unc-5 Neighboring gene long non-coding RNA:CR44458 Neighboring gene long non-coding RNA:CR44459 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent DNA damage sensor activity  
    enables mismatched DNA binding  
    Process Evidence Code Pubs
    involved_in mismatch repair  
    involved_in mismatch repair  
    Component Evidence Code Pubs
    part_of MutLalpha complex  
    part_of mismatch repair complex  

    General protein information

    Preferred Names
    Pms2
    Names
    CG8169-PA
    Pms2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15368074..15371520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057675.4 → NP_477023.1  Pms2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA03, Q8T9C0
      Related
      FBpp0086520
      Conserved Domains (4) summary
      smart00853
      Location:703 → 847
      MutL_C; MutL C terminal dimerisation domain
      COG0323
      Location:26 → 880
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
      cd03484
      Location:238 → 381
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      cl00075
      Location:46 → 151
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
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