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Alr Augmenter of liver regeneration [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32991, updated on 4-Jan-2025

Summary

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Official Symbol
Alrprovided by FlyBase
Official Full Name
Augmenter of liver regenerationprovided by FlyBase
Primary source
FLYBASE:FBgn0031068
Locus tag
Dmel_CG12534
See related
AllianceGenome:FB:FBgn0031068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alr; CG12534; dErv1; Dmel\CG12534
Summary
Predicted to enable flavin adenine dinucleotide binding activity and flavin-dependent sulfhydryl oxidase activity. Involved in mitochondrial disulfide relay system and tissue regeneration. Predicted to be active in mitochondrion. Is expressed in adult head; ectoderm; organism; and prothoracic leg disc. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Alr in Genome Data Viewer
Location:
18F1-18F1; 1-64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19748314..19750167)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19642347..19644200)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45501 Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene parvin Neighboring gene ATP binding cassette subfamily D member 3 Neighboring gene uncharacterized protein Neighboring gene zelda

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles. Murari A, et al. STAR Protoc, 2021 Dec 17. PMID 34977670, Free PMC Article
  2. Three genes control the timing, the site and the size of blastema formation in Drosophila. McClure KD, et al. Dev Biol, 2008 Jul 1. PMID 18485344, Free PMC Article
  3. An antibody toolbox to track complex I assembly defines AIF's mitochondrial function. Murari A, et al. J Cell Biol, 2020 Oct 5. PMID 32936885, Free PMC Article
  4. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Weake VM, et al. EMBO J, 2008 Jan 23. PMID 18188155, Free PMC Article
  5. A protein network-guided screen for cell cycle regulators in Drosophila. Guest ST, et al. BMC Syst Biol, 2011 May 6. PMID 21548953, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial disulfide relay system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IC
Inferred by Curator
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
augmenter of liver regeneration
Names
Alr-PA
Alr-PB
CG12534-PA
CG12534-PB
NP_001259731.1
NP_608353.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19748314..19750167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272802.2 → NP_001259731.1  augmenter of liver regeneration, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PVB3
    Conserved Domains (1) summary
    pfam04777
    Location:166 → 257
    Evr1_Alr; Erv1 / Alr family

  2. NM_134509.4 → NP_608353.2  augmenter of liver regeneration, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608353.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUU5
    Conserved Domains (1) summary
    cl02107
    Location:104 → 255
    Evr1_Alr; Erv1 / Alr family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0PVB3 C0PVB3
Q7KUU5 Q7KUU5
Q8SX43 Q8SX43

Gene LinkOut

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