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    Tbp TATA box binding protein [ Mus musculus (house mouse) ]

    Gene ID: 21374, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tbpprovided by MGI
    Official Full Name
    TATA box binding proteinprovided by MGI
    Primary source
    MGI:MGI:101838
    See related
    Ensembl:ENSMUSG00000014767 AllianceGenome:MGI:101838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtf2d; SCA17; TFIID; GTF2D1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within transcription by RNA polymerase II and transcription by RNA polymerase III. Located in cytoplasm and nucleus. Part of RNA polymerase transcription factor SL1 complex and transcription factor TFIID complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study spinocerebellar ataxia type 17. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 40.6), CNS E14 (RPKM 17.0) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Tbp in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15720150..15737689)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15499888..15517427)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120, member B Neighboring gene predicted gene, 49668 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene STARR-positive B cell enhancer ABC_E5573 Neighboring gene STARR-positive B cell enhancer ABC_E5574 Neighboring gene programmed cell death 2 Neighboring gene zinc finger protein 91 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase I core promoter sequence-specific DNA binding  
    enables RNA polymerase I core promoter sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II general transcription initiation factor activity  
    enables RNA polymerase II general transcription initiation factor activity  
    contributes_to RNA polymerase II general transcription initiation factor activity  
    enables RNA polymerase II general transcription initiation factor activity  
    enables RNA polymerase II general transcription initiation factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables RNA polymerase III general transcription initiation factor activity  
    enables RNA polymerase III general transcription initiation factor activity  
    enables TFIIB-class transcription factor binding  
    enables TFIIB-class transcription factor binding  
    enables aryl hydrocarbon receptor binding  
    enables aryl hydrocarbon receptor binding  
    enables core promoter sequence-specific DNA binding  
    enables enzyme binding  
    enables enzyme binding  
    contributes_to protein binding PubMed 
    enables protein binding PubMed 
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation  
    involved_in RNA polymerase I preinitiation complex assembly  
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    acts_upstream_of_or_within transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    involved_in transcription by RNA polymerase II  
    acts_upstream_of_or_within transcription by RNA polymerase III PubMed 
    acts_upstream_of_or_within transcription by RNA polymerase III  
    involved_in transcription by RNA polymerase III  
    involved_in transcription by RNA polymerase III  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of RNA polymerase I transcription regulator complex PubMed 
    part_of RNA polymerase transcription factor SL1 complex PubMed 
    part_of RNA polymerase transcription factor SL1 complex  
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in euchromatin  
    located_in euchromatin  
    located_in female germ cell nucleus PubMed 
    located_in female pronucleus PubMed 
    located_in male germ cell nucleus PubMed 
    located_in male pronucleus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in pronucleus PubMed 
    part_of protein-containing complex  
    part_of transcription factor TFIIA complex  
    part_of transcription factor TFIIA complex  
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    TATA-box-binding protein
    Names
    TATA sequence-binding protein
    TATA-binding factor
    TATA-binding protein
    TATA-box factor
    TFIID core protein
    transcription initiation factor TFIID TBP subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013684.3NP_038712.3  TATA-box-binding protein

      Status: VALIDATED

      Source sequence(s)
      AC154378, AK085037
      Consensus CDS
      CCDS37454.2
      UniProtKB/Swiss-Prot
      O09169, P29037, Q80UL8, Q8C3S1
      UniProtKB/TrEMBL
      Q6RI65
      Related
      ENSMUSP00000124317.2, ENSMUST00000162505.8
      Conserved Domains (2) summary
      PLN00062
      Location:139315
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:139312
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      15720150..15737689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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