Cand2 cullin-associated and neddylation-dissociated 2 (putative) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cand2provided by RGD
Official Full Name: cullin-associated and neddylation-dissociated 2 (putative)provided by RGD
Primary source: RGD:620480
See related: EnsemblRapid:ENSRNOG00000010473 AllianceGenome:RGD:620480
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tip120B
Summary: Enables TBP-class protein binding activity. Predicted to be involved in SCF complex assembly and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 221.6), Heart (RPKM 149.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (150507659..150535755)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (148835050..148864039)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (147686487..147714593)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF complex assembly	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cullin-associated NEDD8-dissociated protein 2

Names: TBP-interacting protein 120B; TBP-interacting protein Tip120B; TBP-interacting protein b; TBP-interacting protein of 120 kDa B; cullin-associated and neddylation-dissociated protein 2; p120 CAND2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181362.2 → NP_852027.2 cullin-associated NEDD8-dissociated protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IKZ4, A6IKZ6, D4AAI5

Related

ENSRNOP00000102500.1, ENSRNOT00000134792.1

Conserved Domains (3) summary

sd00044
Location:864 → 886

HEAT; HEAT repeat [structural motif]

pfam08623
Location:1057 → 1187

TIP120; TATA-binding protein interacting (TIP20)

pfam13513
Location:150 → 202

HEAT_EZ; HEAT-like repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

150507659..150535755

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237004.4 → XP_006237066.1 cullin-associated NEDD8-dissociated protein 2 isoform X1

See identical proteins and their annotated locations for XP_006237066.1

UniProtKB/Swiss-Prot

Q9R0L3, Q9R0L4, Q9R0L5

UniProtKB/TrEMBL

A0A0G2K139, A6IKZ5, G3V7E8

Related

ENSRNOP00000014207.4, ENSRNOT00000014207.6

Conserved Domains (3) summary

pfam08623
Location:1095 → 1244

TIP120; TATA-binding protein interacting (TIP20)

pfam13513
Location:188 → 240

HEAT_EZ; HEAT-like repeat

sd00044
Location:902 → 924

HEAT; HEAT repeat [structural motif]