Esrrb estrogen related receptor, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esrrbprovided by MGI
Official Full Name: estrogen related receptor, betaprovided by MGI
Primary source: MGI:MGI:1346832
See related: Ensembl:ENSMUSG00000021255 AllianceGenome:MGI:1346832
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Err2; Errb; Nr3b2; Estrrb
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and somatic stem cell population maintenance. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 40.49 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (86407891..86568402)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (86361117..86521628)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation.
Title: A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation.
Esrrb guides naive pluripotent cells through the formative transcriptional programme.
Title: Esrrb guides naive pluripotent cells through the formative transcriptional programme.
ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
Title: ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
The combined action of Esrrb and Nr5a2 is essential for murine naive pluripotency.
Title: The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.
Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.
Title: Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.
ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia.
Title: ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia.
Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.
Title: Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.
findings provide a better understanding of the molecular mechanism of Esrrb in maintaining Trophoblast stem cells (TSCs) self-renewal and during iTSC reprogramming.
Title: Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs.
Estrogen related receptor beta (ESRRB) regulates the activity of embryonic stem cell (ESC)-specific enhancer units. The developmentally regulated silencing of ESRRB triggers the selective inactivation of these units within super-enhancers (SEs).
Title: Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency.
Esrrb functions as an upstream factor of Bmp4 in the ExE, regulating proper primordial germ cell development in mice
Title: Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Mit193 (e-PCR), detects polymorphism
- UniSTS:126747

NoName (e-PCR)
- UniSTS:236911

Esrrb (e-PCR), detects polymorphism
- UniSTS:305548

Esrrb (e-PCR), detects polymorphism
- UniSTS:143008

Esrrb (e-PCR), detects polymorphism
- UniSTS:527345

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell dedifferentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophectodermal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cellular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of integrator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: steroid hormone receptor ERR2

Names: ERR-beta; estrogen receptor related 2; estrogen receptor-like 2; nuclear receptor subfamily 3 group B member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159500.1 → NP_001152972.1 steroid hormone receptor ERR2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK052256, AV496316, BC044858

Consensus CDS

CCDS49117.1

UniProtKB/TrEMBL

E9QKA2, Q80VS1

Related

ENSMUSP00000112103.4, ENSMUST00000116402.10

Conserved Domains (2) summary

cd06946
Location:217 → 436

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:103 → 198

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_011934.4 → NP_036064.3 steroid hormone receptor ERR2 isoform 1

See identical proteins and their annotated locations for NP_036064.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AK032025, AK052256, AV496316, BB642270, BC044858

Consensus CDS

CCDS26066.2

UniProtKB/TrEMBL

G5E8P8, Q80VS1

Related

ENSMUSP00000105833.3, ENSMUST00000110204.9

Conserved Domains (2) summary

cd06946
Location:233 → 452

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:119 → 214

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

86407891..86568402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515881.3 → XP_006515944.1 steroid hormone receptor ERR2 isoform X1

UniProtKB/TrEMBL

Q80VS1

Related

ENSMUSP00000131335.2, ENSMUST00000167891.2

Conserved Domains (2) summary

cd06946
Location:219 → 438

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:105 → 200

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_006515883.4 → XP_006515946.1 steroid hormone receptor ERR2 isoform X3

Conserved Domains (2) summary

cd06946
Location:52 → 271

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 33

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_006515882.3 → XP_006515945.1 steroid hormone receptor ERR2 isoform X2

Conserved Domains (2) summary

cd06946
Location:112 → 331

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:33 → 93

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers