U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Taf1c TATA-box binding protein associated factor, RNA polymerase I, C [ Mus musculus (house mouse) ]

Gene ID: 21341, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Taf1cprovided by MGI
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I, Cprovided by MGI
Primary source
MGI:MGI:109576
See related
Ensembl:ENSMUSG00000031832 AllianceGenome:MGI:109576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tafi95; mTAFI95
Summary
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly. Predicted to act upstream of or within transcription by RNA polymerase I. Part of RNA polymerase transcription factor SL1 complex. Is expressed in limb and limb mesenchyme. Orthologous to human TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 32.3), ovary adult (RPKM 15.5) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Taf1c in Genome Data Viewer
Location:
8 E1; 8 68.02 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120324713..120331945, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119597974..119605206, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene STARR-seq mESC enhancer starr_22853 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122082621-122082922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087691-122087878 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087910-122088232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122093859-122094132 Neighboring gene hydroxysteroid dehydrogenase like 1 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene adenosine deaminase domain containing 2 Neighboring gene potassium voltage-gated channel, subfamily G, member 4 Neighboring gene predicted gene, 46055

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27). Almendral JM, et al. Exp Cell Res, 1989 Apr. PMID 2924801
  2. AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription. Okuda H, et al. Nat Commun, 2015 Nov 23. PMID 26593443, Free PMC Article
  3. Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex. Murano K, et al. J Cell Sci, 2014 Aug 1. PMID 24928901
  4. Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. Heix J, et al. Proc Natl Acad Sci U S A, 1997 Mar 4. PMID 9050847, Free PMC Article
  5. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase I core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase I core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase I general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase I general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase I preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription by RNA polymerase I TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase I transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 
part_of RNA polymerase transcription factor SL1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase transcription factor SL1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit C
Names
RNA polymerase I-specific TBP-associated factor 95 kDa
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; transcription factor TAFI95
TATA box-binding protein-associated factor 1C
TBP-associated factor 1C
TBP-associated factor RNA polymerase I 95 kDa
transcription factor TAFI95
transcription initiation factor SL1/TIF-IB subunit C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378901.1 → NP_001365830.1  TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104882

  2. NM_021441.3 → NP_067416.2  TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1

    See identical proteins and their annotated locations for NP_067416.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC104882
    Consensus CDS
    CCDS40493.1
    UniProtKB/Swiss-Prot
    P97359, Q3U3B6, Q6PDZ2, Q8BN54
    UniProtKB/TrEMBL
    Q3U0N4
    Related
    ENSMUSP00000090789.7, ENSMUST00000093099.13

RNA

  1. NR_166169.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104882
    Related
    ENSMUST00000147964.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120324713..120331945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDZ2.1 GenPept UniProtKB/Swiss-Prot:Q6PDZ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous